| # | Title | Journal | Year | Citations |
|---|
| 1 | Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond | Statistics in Medicine | 2008 | 5,331 |
| 2 | Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart Study | New England Journal of Medicine | 1990 | 5,183 |
| 3 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 4 | Obesity and the Risk of Heart Failure | New England Journal of Medicine | 2002 | 2,550 |
| 5 | Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study | JAMA - Journal of the American Medical Association | 1994 | 2,208 |
| 6 | Vitamin D Deficiency and Risk of Cardiovascular Disease | Circulation | 2008 | 2,077 |
| 7 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 8 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 9 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,789 |
| 10 | Impact of High-Normal Blood Pressure on the Risk of Cardiovascular Disease | New England Journal of Medicine | 2001 | 1,729 |
| 11 | Temporal Relations of Atrial Fibrillation and Congestive Heart Failure and Their Joint Influence on Mortality | Circulation | 2003 | 1,710 |
| 12 | Plasma Natriuretic Peptide Levels and the Risk of Cardiovascular Events and Death | New England Journal of Medicine | 2004 | 1,331 |
| 13 | Comments on ‘Integrated discrimination and net reclassification improvements—Practical advice’ | Statistics in Medicine | 2008 | 1,299 |
| 14 | Obesity and the Risk of New-Onset Atrial Fibrillation | JAMA - Journal of the American Medical Association | 2004 | 1,188 |
| 15 | Multiple Biomarkers for the Prediction of First Major Cardiovascular Events and Death | New England Journal of Medicine | 2006 | 1,167 |
| 16 | Residual Lifetime Risk for Developing Hypertension in Middle-aged Women and Men | JAMA - Journal of the American Medical Association | 2002 | 1,125 |
| 17 | Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes | Nature Genetics | 2018 | 1,124 |
| 18 | Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program | Nature | 2021 | 1,069 |
| 19 | Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study | JAMA - Journal of the American Medical Association | 1994 | 1,036 |
| 20 | Echocardiographic predictors of nonrheumatic atrial fibrillation. The Framingham Heart Study. | Circulation | 1994 | 925 |
| 21 | Left Atrial Size and the Risk of Stroke and Death | Circulation | 1995 | 906 |
| 22 | Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study | Lancet, The | 2009 | 883 |
| 23 | Impact of Obesity on Plasma Natriuretic Peptide Levels | Circulation | 2004 | 856 |
| 24 | Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution | Nature Genetics | 2010 | 836 |
| 25 | Prevalence, clinical features and prognosis of diastolic heart failure: An epidemiologic perspective | Journal of the American College of Cardiology | 1995 | 801 |
| 26 | Soft Drink Consumption and Risk of Developing Cardiometabolic Risk Factors and the Metabolic Syndrome in Middle-Aged Adults in the Community | Circulation | 2007 | 795 |
| 27 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 28 | A Risk Score for Predicting Stroke or Death in Individuals With New-Onset Atrial Fibrillation in the Community | JAMA - Journal of the American Medical Association | 2003 | 703 |
| 29 | New insights into the genetic etiology of Alzheimer’s disease and related dementias | Nature Genetics | 2022 | 700 |
| 30 | Relation of pooled logistic regression to time dependent cox regression analysis: The framingham heart study | Statistics in Medicine | 1990 | 681 |
| 31 | Inflammatory Markers and Risk of Heart Failure in Elderly Subjects Without Prior Myocardial Infarction | Circulation | 2003 | 652 |
| 32 | Left Ventricular Mass and Incidence of Coronary Heart Disease in an Elderly Cohort | Annals of Internal Medicine | 1989 | 647 |
| 33 | The incidence and natural history of knee osteoarthritis in the elderly, the framingham osteoarthritis study | Arthritis and Rheumatism | 1995 | 618 |
| 34 | An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans | Diabetes | 2017 | 615 |
| 35 | Clustering of Metabolic Factors and Coronary Heart Disease | Archives of Internal Medicine | 1999 | 589 |
| 36 | Relation of Disease Pathogenesis and Risk Factors to Heart Failure With Preserved or Reduced Ejection Fraction | Circulation | 2009 | 588 |
| 37 | Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture | Nature Genetics | 2013 | 578 |
| 38 | Prognostic implications of baseline electrocardiographic features and their serial changes in subjects with left ventricular hypertrophy. | Circulation | 1994 | 565 |
| 39 | Clinical Correlates and Heritability of Flow-Mediated Dilation in the Community | Circulation | 2004 | 551 |
| 40 | Intermittent Claudication | Circulation | 1997 | 536 |
| 41 | Natural History of Asymptomatic Left Ventricular Systolic Dysfunction in the Community | Circulation | 2003 | 519 |
| 42 | The changing prevalence and incidence of dementia over time — current evidence | Nature Reviews Neurology | 2017 | 503 |
| 43 | Clinical Utility of Different Lipid Measures for Prediction of Coronary Heart Disease in Men and Women | JAMA - Journal of the American Medical Association | 2007 | 496 |
| 44 | Long-term Outcomes in Individuals With Prolonged PR Interval or First-Degree Atrioventricular Block | JAMA - Journal of the American Medical Association | 2009 | 480 |
| 45 | Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease | JAMA Neurology | 2017 | 454 |
| 46 | Impact of Glucose Intolerance and Insulin Resistance on Cardiac Structure and Function | Circulation | 2003 | 451 |
| 47 | Prevention of Atrial Fibrillation | Circulation | 2009 | 446 |
| 48 | Adiposity, Cardiometabolic Risk, and Vitamin D Status: The Framingham Heart Study | Diabetes | 2010 | 437 |
| 49 | Risk stratification in hypertension: new insights from the Framingham study*1 | American Journal of Hypertension | 2000 | 430 |
| 50 | Prognostic Utility of Novel Biomarkers of Cardiovascular Stress | Circulation | 2012 | 414 |
