| # | Title | Journal | Year | Citations |
|---|
| 1 | The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade | Antiviral Research | 2020 | 1,450 |
| 2 | Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom Resolution | Journal of Virology | 2007 | 378 |
| 3 | Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies | Cell Reports | 2019 | 274 |
| 4 | DisProt 7.0: a major update of the database of disordered proteins | Nucleic Acids Research | 2017 | 242 |
| 5 | Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus | Virus Research | 2014 | 191 |
| 6 | Structure of human lysosomal acid α-glucosidase–a guide for the treatment of Pompe disease | Nature Communications | 2017 | 169 |
| 7 | Evolutionary origin of inhibitor cystine knot peptides | FASEB Journal | 2003 | 140 |
| 8 | Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture | EMBO Journal | 2001 | 138 |
| 9 | Structural basis for the unusual carbohydrate-binding specificity of jacalin towards galactose and mannose | Biochemical Journal | 2002 | 138 |
| 10 | Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection | PLoS Pathogens | 2015 | 138 |
| 11 | LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis | EMBO Journal | 2006 | 126 |
| 12 | Medium-Scale Structural Genomics: Strategies for Protein Expression and Crystallization | Accounts of Chemical Research | 2003 | 116 |
| 13 | Archaea: Essential inhabitants of the human digestive microbiota | Human Microbiome Journal | 2017 | 113 |
| 14 | Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives | Journal of Virology | 2017 | 109 |
| 15 | Structure of the Respiratory Syncytial Virus Polymerase Complex | Cell | 2019 | 108 |
| 16 | K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom | Biochemical Journal | 2005 | 103 |
| 17 | Crystal Structure of Streptococcus pneumoniae N-Acetylglucosamine-1-phosphate Uridyltransferase Bound to Acetyl-coenzyme A Reveals a Novel Active Site Architecture | Journal of Biological Chemistry | 2001 | 92 |
| 18 | ANISEED 2017: extending the integrated ascidian database to the exploration and evolutionary comparison of genome-scale datasets | Nucleic Acids Research | 2018 | 90 |
| 19 | The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection | Scientific Reports | 2016 | 88 |
| 20 | Solution structure of maurotoxin, a scorpion toxin fromScorpio maurus, with high affinity for voltage-gated potassium channels | Proteins: Structure, Function and Bioinformatics | 1997 | 87 |
| 21 | A new fold in the scorpion toxin family, associated with an activity on a ryanodine-sensitive calcium channel | Proteins: Structure, Function and Bioinformatics | 2000 | 87 |
| 22 | Selective Serotonin Reuptake Inhibitor Fluoxetine Inhibits Replication of Human Enteroviruses B and D by Targeting Viral Protein 2C | Antimicrobial Agents and Chemotherapy | 2013 | 81 |
| 23 | Genomic and transcriptomic analysis of Laccaria bicolor CAZome reveals insights into polysaccharides remodelling during symbiosis establishment | Fungal Genetics and Biology | 2014 | 81 |
| 24 | Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins | Journal of Medicinal Chemistry | 2016 | 79 |
| 25 | Galactosaminogalactan activates the inflammasome to provide host protection | Nature | 2020 | 78 |
| 26 | The functional dyad of scorpion toxin Pi1 is not itself a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels | Biochemical Journal | 2004 | 74 |
| 27 | A medium-throughput crystallization approach | Acta Crystallographica Section D: Biological Crystallography | 2002 | 73 |
| 28 | Structure-Activity Relationship Study of Biflavonoids on the Dengue Virus Polymerase DENV-NS5 RdRp | Planta Medica | 2013 | 73 |
| 29 | Substrate (aglycone) specificity of human cytosolic beta-glucosidase | Biochemical Journal | 2003 | 70 |
| 30 | Capping pores of alphavirus nsP1 gate membranous viral replication factories | Nature | 2021 | 67 |
| 31 | Molecular Basis for Nucleotide Conservation at the Ends of the Dengue Virus Genome | PLoS Pathogens | 2012 | 66 |
| 32 | Alkylated Flavanones from the Bark of Cryptocarya chartacea As Dengue Virus NS5 Polymerase Inhibitors | Journal of Natural Products | 2011 | 64 |
| 33 | Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity | Journal of Virology | 2022 | 64 |
| 34 | Mycobacterium tuberculosis Complex Mycobacteria as Amoeba-Resistant Organisms | PLoS ONE | 2011 | 62 |
| 35 | Expression and characterization of the protein Rv1399c from Mycobacterium tuberculosis | FEBS Journal | 2004 | 61 |
| 36 | Semantic similarity over the gene ontology | FEBS Journal | 2005 | 61 |
| 37 | Binding of the Methyl Donor S -Adenosyl- l -Methionine to Middle East Respiratory Syndrome Coronavirus 2′- O -Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10 | Journal of Virology | 2017 | 61 |
| 38 | Solution structure of a chemosensory protein from the moth Mamestra brassicae | Biochemical Journal | 2003 | 60 |
| 39 | The chimeric nature of the genomes of marine magnetotactic coccoid‐ovoid bacteria defines a novel group of Proteobacteria | Environmental Microbiology | 2017 | 60 |
| 40 | Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase | European Journal of Medicinal Chemistry | 2020 | 56 |
| 41 | The active conformation of human glucokinase is not altered by allosteric activators | Acta Crystallographica Section D: Biological Crystallography | 2011 | 53 |
| 42 | Tracing the origins of SARS-COV-2 in coronavirus phylogenies: a review | Environmental Chemistry Letters | 2021 | 53 |
| 43 | Effect of Rickettsial Toxin VapC on Its Eukaryotic Host | PLoS ONE | 2011 | 51 |
| 44 | Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases | Viruses | 2018 | 50 |
| 45 | X-ray structure and activities of an essential Mononegavirales L-protein domain | Nature Communications | 2015 | 49 |
| 46 | Host PDZ‐containing proteins targeted by SARS‐CoV‐2 | FEBS Journal | 2021 | 48 |
| 47 | Characterization of Amm VIII from Androctonus mauretanicus mauretanicus: a new scorpion toxin that discriminates between neuronal and skeletal sodium channels | Biochemical Journal | 2003 | 46 |
| 48 | Exploiting Antigenic Diversity for Vaccine Design | Journal of Biological Chemistry | 2010 | 44 |
| 49 | Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay | Antiviral Research | 2017 | 43 |
| 50 | Solution structure of TsKapa, a charybdotoxin-like scorpion toxin fromTityus serrulatus with high affinity for apamin-sensitive Ca2+-activated K+ channels | Proteins: Structure, Function and Bioinformatics | 1997 | 41 |
