| # | Title | Journal | Year | Citations |
|---|
| 1 | The causal relation between human papillomavirus and cervical cancer | Journal of Clinical Pathology | 2002 | 2,777 |
| 2 | Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis | Cancer Cell | 2009 | 2,168 |
| 3 | Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study | Lancet Oncology, The | 2010 | 2,093 |
| 4 | Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study | Lancet, The | 2019 | 1,804 |
| 5 | Global Epigenomic Reconfiguration During Mammalian Brain Development | Science | 2013 | 1,609 |
| 6 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 7 | Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis | Cancer Cell | 2014 | 1,293 |
| 8 | DNA Methylation and Cancer | Advances in Genetics | 2010 | 1,238 |
| 9 | The Biology and Life-Cycle of Human Papillomaviruses | Vaccine | 2012 | 1,042 |
| 10 | Autophagy maintains stemness by preventing senescence | Nature | 2016 | 1,013 |
| 11 | A Short Screener Is Valid for Assessing Mediterranean Diet Adherence among Older Spanish Men and Women | Journal of Nutrition | 2011 | 973 |
| 12 | Against which human papillomavirus types shall we vaccinate and screen? the international perspective | International Journal of Cancer | 2004 | 912 |
| 13 | Geriatric muscle stem cells switch reversible quiescence into senescence | Nature | 2014 | 785 |
| 14 | Cell death induced by endoplasmic reticulum stress | FEBS Journal | 2016 | 764 |
| 15 | Male Circumcision, Penile Human Papillomavirus Infection, and Cervical Cancer in Female Partners | New England Journal of Medicine | 2002 | 707 |
| 16 | Etiology, Reasons for Hospitalization, Risk Classes, and Outcomes of Community‐Acquired Pneumonia in Patients Hospitalized on the Basis of Conventional Admission Criteria | Clinical Infectious Diseases | 2001 | 703 |
| 17 | DNA methylation profiling in the clinic: applications and challenges | Nature Reviews Genetics | 2012 | 675 |
| 18 | Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study | BMJ: British Medical Journal | 2005 | 614 |
| 19 | Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus | Genome Research | 2010 | 569 |
| 20 | Aberrant Epigenetic Landscape in Cancer: How Cellular Identity Goes Awry | Developmental Cell | 2010 | 529 |
| 21 | Interrogating open issues in cancer precision medicine with patient-derived xenografts | Nature Reviews Cancer | 2017 | 527 |
| 22 | Ribosome biogenesis in cancer: new players and therapeutic avenues | Nature Reviews Cancer | 2018 | 524 |
| 23 | Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis | Nature Genetics | 2009 | 482 |
| 24 | Pembrolizumab for Treatment-Refractory Metastatic Castration-Resistant Prostate Cancer: Multicohort, Open-Label Phase II KEYNOTE-199 Study | Journal of Clinical Oncology | 2020 | 450 |
| 25 | Cancer epigenomics: beyond genomics | Current Opinion in Genetics and Development | 2012 | 421 |
| 26 | Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy | Acta Neuropathologica | 2016 | 380 |
| 27 | A randomized multicentre trial to compare revascularization with optimal medical therapy for the treatment of chronic total coronary occlusions | European Heart Journal | 2018 | 380 |
| 28 | Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases | JAMA Oncology | 2017 | 376 |
| 29 | Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline | Clinical Infectious Diseases | 2020 | 367 |
| 30 | Early response with dasatinib or imatinib in chronic myeloid leukemia: 3-year follow-up from a randomized phase 3 trial (DASISION) | Blood | 2014 | 364 |
| 31 | Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline | Clinical Infectious Diseases | 2020 | 357 |
| 32 | DNA methylation contributes to natural human variation | Genome Research | 2013 | 353 |
| 33 | Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS/ERS/ESCMID/IDSA clinical practice guideline | European Respiratory Journal | 2020 | 336 |
| 34 | Epidemiology and burden of HPV-related disease | Best Practice and Research in Clinical Obstetrics and Gynaecology | 2018 | 323 |
| 35 | Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF–VEGFR2 signalling | Nature | 2012 | 315 |
| 36 | Recent Advances in Cancer Therapy: An Overview | Current Pharmaceutical Design | 2010 | 314 |
| 37 | Dyrk1A Haploinsufficiency Affects Viability and Causes Developmental Delay and Abnormal Brain Morphology in Mice | Molecular and Cellular Biology | 2002 | 306 |
| 38 | Data integration in the era of omics: current and future challenges | BMC Systems Biology | 2014 | 300 |
| 39 | Human papillomavirus and HPV vaccines: a review | Bulletin of the World Health Organization | 2007 | 297 |
| 40 | Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives—a position statement from the European Society for Blood and Marrow Transplantation (EBMT) | Bone Marrow Transplantation | 2015 | 294 |
| 41 | Genomic imprinting disorders: lessons on how genome, epigenome and environment interact | Nature Reviews Genetics | 2019 | 291 |
| 42 | Anatomy of the ankle ligaments: a pictorial essay | Knee Surgery, Sports Traumatology, Arthroscopy | 2010 | 289 |
| 43 | Chromosomal Instability Correlates with Genome-wide DNA Demethylation in Human Primary Colorectal Cancers | Cancer Research | 2006 | 286 |
| 44 | Skin Cancer: Epidemiology, Disease Burden, Pathophysiology, Diagnosis, and Therapeutic Approaches | Dermatology and Therapy | 2017 | 286 |
| 45 | The natural history of human papillomavirus infection | Best Practice and Research in Clinical Obstetrics and Gynaecology | 2018 | 280 |
| 46 | The Epidemiology of Human Papillomavirus Infection and Cervical Cancer | Disease Markers | 2007 | 274 |
| 47 | Subclinical Rejection Associated with Chronic Allograft Nephropathy in Protocol Biopsies as a Risk Factor for Late Graft Loss | American Journal of Transplantation | 2006 | 273 |
| 48 | Non-BRCA DNA Damage Repair Gene Alterations and Response to the PARP Inhibitor Rucaparib in Metastatic Castration-Resistant Prostate Cancer: Analysis From the Phase II TRITON2 Study | Clinical Cancer Research | 2020 | 273 |
| 49 | Human papillomavirus-related oropharyngeal cancer | Annals of Oncology | 2017 | 270 |
| 50 | Geographic distribution and regional origin of 272 cystic fibrosis mutations in European populations | | 1997 | 251 |
