| # | Title | Journal | Year | Citations |
|---|
| 1 | The Timed “Up & Go”: A Test of Basic Functional Mobility for Frail Elderly Persons | Journal of the American Geriatrics Society | 1991 | 10,854 |
| 2 | Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study | BMJ: British Medical Journal | 2000 | 7,060 |
| 3 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 4,038 |
| 4 | Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery | Journal of the American College of Cardiology | 2002 | 3,941 |
| 5 | A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene | Science | 2006 | 2,739 |
| 6 | Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease | Nature Genetics | 2008 | 2,422 |
| 7 | Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma | Clinical Cancer Research | 2004 | 2,393 |
| 8 | HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation | Nature Medicine | 2009 | 1,519 |
| 9 | Somatostatin and Its Receptor Family | Frontiers in Neuroendocrinology | 1999 | 1,440 |
| 10 | Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction | Nature Medicine | 2006 | 1,376 |
| 11 | Summary and Recommendations of the Fifth International Workshop-Conference on Gestational Diabetes Mellitus | Diabetes Care | 2007 | 1,201 |
| 12 | Multipotent CNS Stem Cells Are Present in the Adult Mammalian Spinal Cord and Ventricular Neuroaxis | Journal of Neuroscience | 1996 | 1,145 |
| 13 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes | World Journal of Gastroenterology | 2018 | 1,136 |
| 14 | Interpretive description: A noncategorical qualitative alternative for developing nursing knowledge | Research in Nursing and Health | 1997 | 1,130 |
| 15 | British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus | Gut | 2014 | 1,116 |
| 16 | MICRODETERMINATION OF OXYHEMOGLOBIN, METHEMOGLOBIN, AND SULFHEMOGLOBIN IN A SINGLE SAMPLE OF BLOOD | Journal of Biological Chemistry | 1938 | 1,051 |
| 17 | Low-Dose Inhaled Corticosteroids and the Prevention of Death from Asthma | New England Journal of Medicine | 2000 | 1,039 |
| 18 | The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis.. | British Journal of Dermatology | 1994 | 990 |
| 19 | Fractional Flow Reserve Versus Angiography for Guiding Percutaneous Coronary Intervention in Patients With Multivessel Coronary Artery Disease | Journal of the American College of Cardiology | 2010 | 990 |
| 20 | Transcatheter Aortic Valve Implantation for the Treatment of Severe Symptomatic Aortic Stenosis in Patients at Very High or Prohibitive Surgical Risk | Journal of the American College of Cardiology | 2010 | 929 |
| 21 | Locoregional Radiation Therapy in Patients With High-Risk Breast Cancer Receiving Adjuvant Chemotherapy: 20-Year Results of the British Columbia Randomized Trial | Journal of the National Cancer Institute | 2005 | 926 |
| 22 | Relation of number of positive axillary nodes to the prognosis of patients with primary breast cancer. An NSABP update | Cancer | 1983 | 924 |
| 23 | The Role of the IGF System in Cancer Growth and Metastasis: Overview and Recent Insights | Endocrine Reviews | 2007 | 902 |
| 24 | TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria | Lancet, The | 1990 | 868 |
| 25 | The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. | Journal of Clinical Investigation | 1996 | 860 |
| 26 | Increased Plasma Endothelin-1 in Pulmonary Hypertension: Marker or Mediator of Disease? | Annals of Internal Medicine | 1991 | 854 |
| 27 | The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease | BMJ: British Medical Journal | 2008 | 825 |
| 28 | Cancer Of The Colon | Annals of Surgery | 1967 | 818 |
| 29 | The Hyperglycemia and Adverse Pregnancy Outcome Study | Diabetes Care | 2012 | 775 |
| 30 | Short GCG expansions in the PABP2 gene cause oculopharyngeal muscular dystrophy | Nature Genetics | 1998 | 751 |
| 31 | How many steps/day are enough? For older adults and special populations | International Journal of Behavioral Nutrition and Physical Activity | 2011 | 734 |
| 32 | Daratumumab monotherapy in patients with treatment-refractory multiple myeloma (SIRIUS): an open-label, randomised, phase 2 trial | Lancet, The | 2016 | 724 |
| 33 | Impact of left ventricular hypertrophy on survival in end-stage renal disease | Kidney International | 1989 | 696 |
| 34 | The Prolactin/Growth Hormone Receptor Family | Endocrine Reviews | 1991 | 692 |
| 35 | The Immune-Hypothalamic-Pituitary-Adrenal Axis* | Endocrine Reviews | 1989 | 677 |
| 36 | Long-term efficacy and safety of zoledronic acid in the treatment of skeletal metastases in patients with nonsmall cell lung carcinoma and other solid tumors | Cancer | 2004 | 647 |
| 37 | A Radioimmunoassay for Human Prolactin | Proceedings of the National Academy of Sciences of the United States of America | 1971 | 626 |
| 38 | ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis | Nature Genetics | 2006 | 617 |
| 39 | A hierarchical Bayesian meta-analysis of randomised clinical trials of drug-eluting stents | Lancet, The | 2004 | 597 |
| 40 | Birth weight and non-insulin dependent diabetes: thrifty genotype, thrifty phenotype, or surviving small baby genotype? | BMJ: British Medical Journal | 1994 | 594 |
| 41 | Targeted ablation of the 25-hydroxyvitamin D 1 -hydroxylase enzyme: Evidence for skeletal, reproductive, and immune dysfunction | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 593 |
| 42 | Formation of reactive oxygen species in spermatozoa of infertile patients | Fertility and Sterility | 1992 | 588 |
| 43 | Cloning and expression of the rat prolactin receptor, a member of the growth hormone/prolactin receptor gene family | Cell | 1988 | 575 |
| 44 | A MOBILE INTENSIVE-CARE UNIT IN THE MANAGEMENT OF MYOCARDIAL INFARCTION | Lancet, The | 1967 | 574 |
| 45 | Differential Control of Bmal1 Circadian Transcription by REV-ERB and ROR Nuclear Receptors | Journal of Biological Rhythms | 2005 | 572 |
| 46 | Application of New Cholesterol Guidelines to a Population-Based Sample | New England Journal of Medicine | 2014 | 571 |
| 47 | Frequency of Gestational Diabetes Mellitus at Collaborating Centers Based on IADPSG Consensus Panel–Recommended Criteria | Diabetes Care | 2012 | 568 |
| 48 | Relation between severe malaria morbidity in children and level of Plasmodium falciparum transmission in Africa | Lancet, The | 1997 | 561 |
| 49 | Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21 | Nature Genetics | 2008 | 542 |
| 50 | Reactive oxygen species and sperm physiology | Reproduction | 1997 | 540 |
