| # | Title | Journal | Year | Citations |
|---|
| 1 | Acute Renal Failure in Critically Ill PatientsA Multinational, Multicenter Study | JAMA - Journal of the American Medical Association | 2005 | 3,514 |
| 2 | Stroke | Lancet, The | 2008 | 2,127 |
| 3 | Antibody therapy of cancer | Nature Reviews Cancer | 2012 | 1,861 |
| 4 | Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study | Intensive Care Medicine | 2015 | 1,838 |
| 5 | Variability of Blood Glucose Concentration and Short-term Mortality in Critically Ill Patients | Anesthesiology | 2006 | 1,305 |
| 6 | Continuous renal replacement therapy: A worldwide practice survey | Intensive Care Medicine | 2007 | 1,020 |
| 7 | doublecortin, a Brain-Specific Gene Mutated in Human X-Linked Lissencephaly and Double Cortex Syndrome, Encodes a Putative Signaling Protein | Cell | 1998 | 1,007 |
| 8 | Acute kidney injury | Lancet, The | 2019 | 950 |
| 9 | Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes | Methods | 2012 | 943 |
| 10 | A practical computer-based approach to the analysis of radioligand binding experiments | Computer Programs in Biomedicine | 1983 | 802 |
| 11 | Cardio-renal syndromes: report from the consensus conference of the Acute Dialysis Quality Initiative | European Heart Journal | 2010 | 797 |
| 12 | First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in patients with non-small-cell lung cancer (CheckMate 9LA): an international, randomised, open-label, phase 3 trial | Lancet Oncology, The | 2021 | 773 |
| 13 | Respiratory rate: the neglected vital sign | Medical Journal of Australia | 2008 | 707 |
| 14 | Hemodialysis Membrane With a High-Molecular-Weight Cutoff and Cytokine Levels in Sepsis Complicated by Acute Renal Failure: A Phase 1 Randomized Trial | American Journal of Kidney Diseases | 2007 | 639 |
| 15 | Size-Dependent Immunogenicity: Therapeutic and Protective Properties of Nano-Vaccines against Tumors | Journal of Immunology | 2004 | 603 |
| 16 | Reduced Bone Mass in Daughters of Women with Osteoporosis | New England Journal of Medicine | 1989 | 585 |
| 17 | Anti-pig IgM antibodies in human serum react predominantly with Gal(alpha 1-3)Gal epitopes | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 575 |
| 18 | Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase | Gastroenterology | 2003 | 562 |
| 19 | Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery | New England Journal of Medicine | 2018 | 561 |
| 20 | Autosomal dominant nocturnal frontal lobe epilepsy | Brain | 1995 | 523 |
| 21 | Early acute kidney injury and sepsis: a multicentre evaluation | Critical Care | 2008 | 517 |
| 22 | Reactive Oxygen Species Enhance Insulin Sensitivity | Cell Metabolism | 2009 | 509 |
| 23 | A comparison of the RIFLE and AKIN criteria for acute kidney injury in critically ill patients | Nephrology Dialysis Transplantation | 2008 | 494 |
| 24 | Acute kidney injury in sepsis | Intensive Care Medicine | 2017 | 490 |
| 25 | Effects of Fenofibrate Treatment on Cardiovascular Disease Risk in 9,795 Individuals With Type 2 Diabetes and Various Components of the Metabolic Syndrome | Diabetes Care | 2009 | 488 |
| 26 | Preoperative MRI predicts outcome of temporal lobectomy | Neurology | 1995 | 485 |
| 27 | Treatment Outcomes for Serious Infections Caused by Methicillin‐ResistantStaphylococcus aureuswith Reduced Vancomycin Susceptibility | Clinical Infectious Diseases | 2004 | 467 |
| 28 | Tecemotide (L-BLP25) versus placebo after chemoradiotherapy for stage III non-small-cell lung cancer (START): a randomised, double-blind, phase 3 trial | Lancet Oncology, The | 2014 | 446 |
| 29 | The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement | Blood | 2008 | 421 |
| 30 | Percutaneous dilatational tracheostomy versus surgical tracheostomy in critically ill patients: a systematic review and meta-analysis | Critical Care | 2006 | 411 |
| 31 | Ledipasvir and sofosbuvir plus ribavirin in patients with genotype 1 or 4 hepatitis C virus infection and advanced liver disease: a multicentre, open-label, randomised, phase 2 trial | Lancet Infectious Diseases, The | 2016 | 402 |
| 32 | Internet-Based Cognitive Behavioral Therapy for Depression | JAMA Psychiatry | 2021 | 398 |
| 33 | Avoidance of Nitrous Oxide for Patients Undergoing Major Surgery | Anesthesiology | 2007 | 397 |
| 34 | Expert consensus and recommendations on safety criteria for active mobilization of mechanically ventilated critically ill adults | Critical Care | 2014 | 391 |
| 35 | Human Melatonin Suppression by Light is Intensity Dependent | Journal of Pineal Research | 1989 | 389 |
| 36 | Stereotactic ablative radiotherapy versus standard radiotherapy in stage 1 non-small-cell lung cancer (TROG 09.02 CHISEL): a phase 3, open-label, randomised controlled trial | Lancet Oncology, The | 2019 | 386 |
| 37 | Retardation by Aminoguanidine of Development of Albuminuria, Mesangial Expansion, and Tissue Fluorescence in Streptozocin-Induced Diabetic Rat | Diabetes | 1991 | 384 |
| 38 | Minimally Invasive Measurement of Cardiac Output during Surgery and Critical Care | Anesthesiology | 2010 | 379 |
| 39 | Hypoglycemia and Outcome in Critically Ill Patients | Mayo Clinic Proceedings | 2010 | 378 |
| 40 | Hippocampal sclerosis can be reliably detected by magnetic resonance imaging | Neurology | 1990 | 372 |
| 41 | Periosteal Bone Formation — A Neglected Determinant of Bone Strength | New England Journal of Medicine | 2003 | 368 |
| 42 | Very old patients admitted to intensive care in Australia and New Zealand: a multi-centre cohort analysis | Critical Care | 2009 | 364 |
| 43 | Tumor necrosis factor α-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling | Cell Metabolism | 2006 | 363 |
| 44 | Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease | Seminars in Nephrology | 2005 | 350 |
| 45 | Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock | JAMA - Journal of the American Medical Association | 2020 | 342 |
| 46 | Autosomal dominant frontal epilepsy misdiagnosed as sleep disorder | Lancet, The | 1994 | 340 |
| 47 | Resuscitation fluid use in critically ill adults: an international cross sectional study in 391 intensive care units | Critical Care | 2010 | 337 |
| 48 | Excitatory amino acid projections to the nucleus accumbens septi in the rat: A retrograde transport study utilizingd[3H]aspartate and [3H]GABA | Neuroscience | 1987 | 332 |
| 49 | Atrial fibrillation after coronary artery bypass grafting is associated with sympathetic activation | Annals of Thoracic Surgery | 1995 | 332 |
| 50 | Mechanisms of Focal Heat Destruction of Liver Tumors | Journal of Surgical Research | 2005 | 328 |
