| # | Title | Journal | Year | Citations |
|---|
| 1 | The 2016 revision of the World Health Organization classification of lymphoid neoplasms | Blood | 2016 | 5,965 |
| 2 | CHOP Chemotherapy plus Rituximab Compared with CHOP Alone in Elderly Patients with Diffuse Large-B-Cell Lymphoma | New England Journal of Medicine | 2002 | 4,928 |
| 3 | EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent | European Urology | 2017 | 2,497 |
| 4 | ESUR prostate MR guidelines 2012 | European Radiology | 2012 | 2,176 |
| 5 | Autoantibodies against type I IFNs in patients with life-threatening COVID-19 | Science | 2020 | 1,983 |
| 6 | Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy | Nature Reviews Immunology | 2013 | 1,819 |
| 7 | Prospective Randomized Study of Doxorubicin-Eluting-Bead Embolization in the Treatment of Hepatocellular Carcinoma: Results of the PRECISION V Study | CardioVascular and Interventional Radiology | 2010 | 1,329 |
| 8 | Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial | Lancet Oncology, The | 2015 | 1,269 |
| 9 | EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part II: Treatment of Relapsing, Metastatic, and Castration-Resistant Prostate Cancer | European Urology | 2017 | 1,215 |
| 10 | Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach | Lancet Infectious Diseases, The | 2013 | 1,138 |
| 11 | Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial | Lancet, The | 2012 | 1,041 |
| 12 | Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial | Lancet, The | 2012 | 1,040 |
| 13 | The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms | Leukemia | 2022 | 1,023 |
| 14 | Modern diagnosis of GERD: the Lyon Consensus | Gut | 2018 | 991 |
| 15 | Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma | JAMA - Journal of the American Medical Association | 2015 | 982 |
| 16 | Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): a phase 3, randomised controlled trial | Lancet, The | 2011 | 957 |
| 17 | Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400 | Clinical Neurophysiology | 2009 | 934 |
| 18 | Prism adaptation to a rightward optical deviation rehabilitates left hemispatial neglect | Nature | 1998 | 886 |
| 19 | Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study | Lancet, The | 2012 | 839 |
| 20 | Intertumoral Heterogeneity within Medulloblastoma Subgroups | Cancer Cell | 2017 | 836 |
| 21 | CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner | Journal of Experimental Medicine | 2005 | 806 |
| 22 | Respiratory Variations in Pulse Oximetry Plethysmographic Waveform Amplitude to Predict Fluid Responsiveness in the Operating Room | Anesthesiology | 2007 | 780 |
| 23 | Lung cancer in never smokers – A review | European Journal of Cancer | 2012 | 694 |
| 24 | The Hill equation: a review of its capabilities in pharmacological modelling | Fundamental and Clinical Pharmacology | 2008 | 645 |
| 25 | Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials | BMJ: British Medical Journal | 2011 | 631 |
| 26 | The Ability of a Novel Algorithm for Automatic Estimation of the Respiratory Variations in Arterial Pulse Pressure to Monitor Fluid Responsiveness in the Operating Room | Anesthesia and Analgesia | 2008 | 621 |
| 27 | Assessment of pro-vasopressin and pro-adrenomedullin as predictors of 28-day mortality in septic shock patients | Intensive Care Medicine | 2009 | 621 |
| 28 | Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study | Lancet Oncology, The | 2019 | 611 |
| 29 | Movement Intention After Parietal Cortex Stimulation in Humans | Science | 2009 | 598 |
| 30 | Effect of Endovascular Contact Aspiration vs Stent Retriever on Revascularization in Patients With Acute Ischemic Stroke and Large Vessel Occlusion | JAMA - Journal of the American Medical Association | 2017 | 588 |
| 31 | Factors Associated With Chronic Hepatitis in Patients With Hepatitis E Virus Infection Who Have Received Solid Organ Transplants | Gastroenterology | 2011 | 570 |
| 32 | Belantamab mafodotin for relapsed or refractory multiple myeloma (DREAMM-2): a two-arm, randomised, open-label, phase 2 study | Lancet Oncology, The | 2020 | 544 |
| 33 | Pulmonary Hypertension Due to Left Heart Diseases | Journal of the American College of Cardiology | 2013 | 541 |
| 34 | Zinc and its role in immunity and inflammation | Autoimmunity Reviews | 2015 | 531 |
| 35 | Sirolimus and Secondary Skin-Cancer Prevention in Kidney Transplantation | New England Journal of Medicine | 2012 | 520 |
| 36 | Advances in the understanding and treatment of sepsis-induced immunosuppression | Nature Reviews Nephrology | 2018 | 520 |
| 37 | Prognostic Value of Fractional Flow Reserve | Journal of the American College of Cardiology | 2014 | 513 |
| 38 | ENETS Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Neoplasms: Functional Pancreatic Endocrine Tumor Syndromes | Neuroendocrinology | 2012 | 509 |
| 39 | Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments | PLoS Genetics | 2014 | 501 |
| 40 | Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer | Nature Genetics | 2013 | 493 |
| 41 | The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells | Nature Immunology | 2014 | 484 |
| 42 | Formal guidelines: management of acute respiratory distress syndrome | Annals of Intensive Care | 2019 | 478 |
| 43 | A new highly penetrant form of obesity due to deletions on chromosome 16p11.2 | Nature | 2010 | 476 |
| 44 | On Estimation in Relative Survival | Biometrics | 2012 | 471 |
| 45 | Esophageal motility disorders on high‐resolution manometry: Chicago classification version 4.0© | Neurogastroenterology and Motility | 2021 | 468 |
| 46 | Non-motor dopamine withdrawal syndrome after surgery for Parkinson's disease: predictors and underlying mesolimbic denervation | Brain | 2010 | 453 |
| 47 | Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study | Lancet, The | 2019 | 449 |
| 48 | Ultrasonography of optic nerve sheath diameter for detection of raised intracranial pressure: a systematic review and meta-analysis | Intensive Care Medicine | 2011 | 448 |
| 49 | Postconditioning and protection from reperfusion injury: where do we stand? * Position Paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology | Cardiovascular Research | 2010 | 447 |
| 50 | Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis | Lancet, The | 2022 | 445 |
