| # | Title | Journal | Year | Citations |
|---|
| 1 | Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis | New England Journal of Medicine | 2018 | 1,944 |
| 2 | Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis | New England Journal of Medicine | 2018 | 1,000 |
| 3 | The International Criteria for Behçet's Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria | Journal of the European Academy of Dermatology and Venereology | 2014 | 977 |
| 4 | Tafamidis for transthyretin familial amyloid polyneuropathy | Neurology | 2012 | 658 |
| 5 | Nurse involvement in end-of-life decision making: the ETHICUS Study | Intensive Care Medicine | 2006 | 624 |
| 6 | Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients | Annals of the Rheumatic Diseases | 2015 | 610 |
| 7 | Guideline of transthyretin-related hereditary amyloidosis for clinicians | Orphanet Journal of Rare Diseases | 2013 | 525 |
| 8 | Etiology, Management, and Outcome of the Budd-Chiari Syndrome | Annals of Internal Medicine | 2009 | 422 |
| 9 | Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis | Journal of the American College of Cardiology | 2015 | 344 |
| 10 | Genotype and Phenotype of Transthyretin Cardiac Amyloidosis | Journal of the American College of Cardiology | 2016 | 338 |
| 11 | CNS involvement and treatment with interferon-α are independent prognostic factors in Erdheim-Chester disease: a multicenter survival analysis of 53 patients | Blood | 2011 | 331 |
| 12 | Music and Emotions in the Brain: Familiarity Matters | PLoS ONE | 2011 | 306 |
| 13 | Deposition of Transthyretin in Early Stages of Familial Amyloidotic Polyneuropathy | American Journal of Pathology | 2001 | 303 |
| 14 | Prevalence and Management of Anemia in Renal Transplant Recipients: A European Survey | American Journal of Transplantation | 2003 | 281 |
| 15 | Liver Transplantation for Hereditary Transthyretin Amyloidosis | Transplantation | 2015 | 257 |
| 16 | Efficacy and safety of patisiran for familial amyloidotic polyneuropathy: a phase II multi-dose study | Orphanet Journal of Rare Diseases | 2015 | 246 |
| 17 | Patients' recollections of experiences in the intensive care unit may affect their quality of life | Critical Care | 2005 | 198 |
| 18 | Genetic epidemiology of familial amyloidotic polyneuropathy (FAP)-type I in Póvoa do Varzim and Vila do Conde (north of Portugal) | American Journal of Medical Genetics Part A | 1995 | 195 |
| 19 | Familial Amyloid Polyneuropathy: Receptor for Advanced Glycation End Products-Dependent Triggering of Neuronal Inflammatory and Apoptotic Pathways | Journal of Neuroscience | 2001 | 190 |
| 20 | Long-term lamivudine therapy for children with HBeAg-positive chronic hepatitis B | Hepatology | 2006 | 150 |
| 21 | Quality assessment program for EuroFlow protocols: Summary results of four‐year (2010–2013) quality assurance rounds | Cytometry Part A: the Journal of the International Society for Analytical Cytology | 2015 | 144 |
| 22 | Expert consensus recommendations to improve diagnosis of ATTR amyloidosis with polyneuropathy | Journal of Neurology | 2021 | 141 |
| 23 | Commission on Outcome Measurement in Epilepsy, 1994-1997: Final Report | Epilepsia | 1998 | 134 |
| 24 | A proposal to standardize dyspnoea measurement in clinical trials of acute heart failure syndromes: the need for a uniform approach | European Heart Journal | 2008 | 131 |
| 25 | Patient satisfaction following day surgery | Journal of Clinical Anesthesia | 2009 | 126 |
| 26 | A Novel Dry Active Electrode for EEG Recording | IEEE Transactions on Biomedical Engineering | 2007 | 124 |
| 27 | Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis | Neurology and Therapy | 2016 | 124 |
| 28 | Improvement in the Molecular Diagnosis of Machado-Joseph Disease | Archives of Neurology | 2001 | 121 |
| 29 | Prospective Community-Based Study of Stroke in Northern Portugal | Stroke | 2004 | 117 |
| 30 | Efficacy and safety of sirolimus in the treatment of vascular anomalies: A systematic review | Journal of Vascular Surgery | 2020 | 117 |
| 31 | Review of the disease course among adult ulcerative colitis population-based longitudinal cohorts | Inflammatory Bowel Diseases | 2012 | 116 |
| 32 | Immunophenotypic Analysis of the TCR-Vβ Repertoire in 98 Persistent Expansions of CD3+/TCR-αβ+ Large Granular Lymphocytes | American Journal of Pathology | 2001 | 113 |
| 33 | ERS statement on exercise training and rehabilitation in patients with severe chronic pulmonary hypertension | European Respiratory Journal | 2019 | 110 |
| 34 | Transthyretin Amyloidosis and the Kidney | Clinical Journal of the American Society of Nephrology: CJASN | 2012 | 105 |
| 35 | Transthyretin cardiac amyloidosis in continental Western Europe: an insight through the Transthyretin Amyloidosis Outcomes Survey (THAOS) | European Heart Journal | 2022 | 105 |
| 36 | TCRαβ+/CD4+ Large Granular Lymphocytosis | American Journal of Pathology | 2003 | 104 |
| 37 | The Stroke Riskometer™ App: Validation of a Data Collection Tool and Stroke Risk Predictor | International Journal of Stroke | 2015 | 103 |
| 38 | Reducing mortality in severe sepsis with the implementation of a core 6-hour bundle: results from the Portuguese community-acquired sepsis study (SACiUCI study) | Critical Care | 2010 | 98 |
| 39 | Liver transplantation in transthyretin amyloidosis: Issues and challenges | Liver Transplantation | 2015 | 97 |
| 40 | CNS involvement in V30M transthyretin amyloidosis: clinical, neuropathological and biochemical findings | Journal of Neurology, Neurosurgery and Psychiatry | 2015 | 97 |
| 41 | Efficacy and safety of vutrisiran for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: a randomized clinical trial | Amyloid: the International Journal of Experimental and Clinical Investigation: the Official Journal of the International Society of Amyloidosis | 2023 | 97 |
| 42 | Lisfranc Joint Ligamentous Complex: MRI With Anatomic Correlation in Cadavers | American Journal of Roentgenology | 2010 | 96 |
| 43 | Multicentre evaluation of the VITEK 2 Advanced Expert System for interpretive reading of antimicrobial resistance tests | Journal of Antimicrobial Chemotherapy | 2002 | 95 |
| 44 | Pregnancy outcomes in aquaporin-4–positive neuromyelitis optica spectrum disorder | Neurology | 2016 | 95 |
| 45 | Changes in the Clonal Nature and Antibiotic Resistance Profiles of Methicillin-Resistant Staphylococcus aureus Isolates Associated with Spread of the EMRSA-15 Clone in a Tertiary Care Portuguese Hospital | Journal of Clinical Microbiology | 2007 | 94 |
| 46 | Classification and clinical behavior of blastic plasmacytoid dendritic cell neoplasms according to their maturation-associated immunophenotypic profile | Oncotarget | 2015 | 93 |
| 47 | Inhibition of LOX by flavonoids: a structure–activity relationship study | European Journal of Medicinal Chemistry | 2014 | 87 |
| 48 | TCRγδ+ large granular lymphocyte leukemias reflect the spectrum of normal antigen-selected TCRγδ+ T-cells | Leukemia | 2006 | 86 |
| 49 | The third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke | Trials | 2008 | 86 |
| 50 | TTC7B Emerges as a Novel Risk Factor for Ischemic Stroke Through the Convergence of Several Genome-Wide Approaches | Journal of Cerebral Blood Flow and Metabolism | 2012 | 86 |
