| # | Title | Journal | Year | Citations |
|---|
| 1 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 6,376 |
| 2 | Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial | Lancet, The | 2016 | 5,456 |
| 3 | Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel | Blood | 2017 | 4,375 |
| 4 | Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet | Blood | 2010 | 2,963 |
| 5 | Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study | Lancet Oncology, The | 2010 | 2,093 |
| 6 | Atherosclerosis | Nature Reviews Disease Primers | 2019 | 1,601 |
| 7 | Characteristics and Outcomes in Adult Patients Receiving Mechanical Ventilation<SUBTITLE>A 28-Day International Study</SUBTITLE> | JAMA - Journal of the American Medical Association | 2002 | 1,398 |
| 8 | Classification of the cutaneous manifestations of COVID ‐19: a rapid prospective nationwide consensus study in Spain with 375 cases | British Journal of Dermatology | 2020 | 1,030 |
| 9 | Vascular Anomalies Classification: Recommendations From the International Society for the Study of Vascular Anomalies | Pediatrics | 2015 | 1,026 |
| 10 | Morphine and alternative opioids in cancer pain: the EAPC recommendations | British Journal of Cancer | 2001 | 759 |
| 11 | Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure | Journal of Hepatology | 2014 | 741 |
| 12 | Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial | Lancet, The | 2013 | 688 |
| 13 | Associative Processes in Addiction and Reward The Role of Amygdala‐Ventral Striatal Subsystems | Annals of the New York Academy of Sciences | 1999 | 674 |
| 14 | Uterine sarcomas: A review | Gynecologic Oncology | 2010 | 659 |
| 15 | 10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension | Lancet Diabetes and Endocrinology,the | 2017 | 635 |
| 16 | Cystatin C as a marker of GFR—history, indications, and future research | Clinical Biochemistry | 2005 | 606 |
| 17 | Cerebral State Index during Propofol Anesthesia | Anesthesiology | 2006 | 598 |
| 18 | Grading quality of evidence and strength of recommendations in clinical practice guidelines | Allergy: European Journal of Allergy and Clinical Immunology | 2009 | 596 |
| 19 | Growth Characteristics of Infantile Hemangiomas: Implications for Management | Pediatrics | 2008 | 583 |
| 20 | Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery | JAMA - Journal of the American Medical Association | 2017 | 579 |
| 21 | Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional non-biological and biological anti-tumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, double-blind, placebo-controlled, randomised PSUMMIT 2 trial | Annals of the Rheumatic Diseases | 2014 | 576 |
| 22 | Psoriasis and Systemic Inflammatory Diseases: Potential Mechanistic Links between Skin Disease and Co-Morbid Conditions | Journal of Investigative Dermatology | 2010 | 554 |
| 23 | Epidemiology of atopic dermatitis in adults: Results from an international survey | Allergy: European Journal of Allergy and Clinical Immunology | 2018 | 546 |
| 24 | Terlipressin and Albumin vs Albumin in Patients With Cirrhosis and Hepatorenal Syndrome: A Randomized Study | Gastroenterology | 2008 | 541 |
| 25 | Osimertinib for pretreated EGFR Thr790Met-positive advanced non-small-cell lung cancer (AURA2): a multicentre, open-label, single-arm, phase 2 study | Lancet Oncology, The | 2016 | 533 |
| 26 | Probability and predictors of transition from first use to dependence on nicotine, alcohol, cannabis, and cocaine: Results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) | Drug and Alcohol Dependence | 2011 | 532 |
| 27 | Prospective Study of Infantile Hemangiomas: Clinical Characteristics Predicting Complications and Treatment | Pediatrics | 2006 | 527 |
| 28 | Clinical picture and risk prediction of short‐term mortality in cardiogenic shock | European Journal of Heart Failure | 2015 | 520 |
| 29 | Epidemiology and Predictors of Mortality in Cases of Candida Bloodstream Infection: Results from Population-Based Surveillance, Barcelona, Spain, from 2002 to 2003 | Journal of Clinical Microbiology | 2005 | 505 |
| 30 | HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects | Nature Medicine | 2010 | 500 |
| 31 | Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 | JAMA - Journal of the American Medical Association | 2021 | 498 |
| 32 | Clinical Course of acute‐on‐chronic liver failure syndrome and effects on prognosis | Hepatology | 2015 | 493 |
| 33 | Epidemiology and Treatment of Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa Infections | Clinical Microbiology Reviews | 2019 | 489 |
| 34 | Superiority of denosumab to zoledronic acid for prevention of skeletal-related events: A combined analysis of 3 pivotal, randomised, phase 3 trials | European Journal of Cancer | 2012 | 485 |
| 35 | Neoadjuvant chemotherapy and nivolumab in resectable non-small-cell lung cancer (NADIM): an open-label, multicentre, single-arm, phase 2 trial | Lancet Oncology, The | 2020 | 475 |
| 36 | Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study | Lancet Neurology, The | 2017 | 472 |
| 37 | Initiation and Use of Propranolol for Infantile Hemangioma: Report of a Consensus Conference | Pediatrics | 2013 | 469 |
| 38 | Efficacy and safety of risankizumab in moderate-to-severe plaque psoriasis (UltIMMa-1 and UltIMMa-2): results from two double-blind, randomised, placebo-controlled and ustekinumab-controlled phase 3 trials | Lancet, The | 2018 | 457 |
| 39 | Ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab in first-line treatment of chronic lymphocytic leukaemia (iLLUMINATE): a multicentre, randomised, open-label, phase 3 trial | Lancet Oncology, The | 2019 | 448 |
| 40 | Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features | Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin | 2012 | 442 |
| 41 | Superiority of bortezomib, thalidomide, and dexamethasone (VTD) as induction pretransplantation therapy in multiple myeloma: a randomized phase 3 PETHEMA/GEM study | Blood | 2012 | 429 |
| 42 | Patient perspectives in the management of psoriasis: Results from the population-based Multinational Assessment of Psoriasis and Psoriatic Arthritis Survey | Journal of the American Academy of Dermatology | 2014 | 423 |
| 43 | Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia | Blood | 2013 | 420 |
| 44 | Role of vitamin D in the pathogenesis of type 2 diabetes mellitus | Diabetes, Obesity and Metabolism | 2008 | 410 |
| 45 | Prospective Study of Infantile Hemangiomas: Demographic, Prenatal, and Perinatal Characteristics | Journal of Pediatrics | 2007 | 408 |
| 46 | Neoadjuvant and adjuvant trastuzumab in patients with HER2-positive locally advanced breast cancer (NOAH): follow-up of a randomised controlled superiority trial with a parallel HER2-negative cohort | Lancet Oncology, The | 2014 | 406 |
| 47 | A critical role for elastin signaling in vascular morphogenesis and disease | Development (Cambridge) | 2003 | 400 |
| 48 | Association of Type and Location ofBRCA1andBRCA2Mutations With Risk of Breast and Ovarian Cancer | JAMA - Journal of the American Medical Association | 2015 | 390 |
| 49 | Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused byRASA1 mutations | Human Mutation | 2008 | 382 |
| 50 | Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trial | Lancet, The | 2018 | 373 |
