| # | Title | Journal | Year | Citations |
|---|
| 1 | Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease | American Journal of Respiratory and Critical Care Medicine | 2013 | 7,792 |
| 2 | Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK | Lancet, The | 2021 | 3,887 |
| 3 | Weaning from mechanical ventilation | European Respiratory Journal | 2007 | 1,962 |
| 4 | Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial | Lancet, The | 2008 | 1,759 |
| 5 | Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: the GOLD science committee report 2019 | European Respiratory Journal | 2019 | 1,223 |
| 6 | Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid vs Gemcitabine Following Pancreatic Cancer Resection | JAMA - Journal of the American Medical Association | 2010 | 1,206 |
| 7 | The metrics of glycaemic control in critical care | Intensive Care Medicine | 2011 | 1,078 |
| 8 | 2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren's Syndrome: A Consensus and Data‐Driven Methodology Involving Three International Patient Cohorts | Arthritis and Rheumatology | 2017 | 993 |
| 9 | Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials | Lancet, The | 2021 | 979 |
| 10 | COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study | The Lancet Child and Adolescent Health | 2020 | 978 |
| 11 | 2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome | Annals of the Rheumatic Diseases | 2017 | 959 |
| 12 | A comparison of deep learning performance against health-care professionals in detecting diseases from medical imaging: a systematic review and meta-analysis | The Lancet Digital Health | 2019 | 930 |
| 13 | Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial | Lancet, The | 2018 | 901 |
| 14 | Long-Term Outcomes After Transcatheter Aortic Valve Implantation in High-Risk Patients With Severe Aortic Stenosis | Journal of the American College of Cardiology | 2011 | 839 |
| 15 | Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study | Lancet Oncology, The | 2019 | 773 |
| 16 | Rapid, point-of-care antigen and molecular-based tests for diagnosis of SARS-CoV-2 infection | The Cochrane Library | 2020 | 770 |
| 17 | EULAR Sjögren's syndrome disease activity index: development of a consensus systemic disease activity index for primary Sjögren's syndrome | Annals of the Rheumatic Diseases | 2010 | 734 |
| 18 | Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial | Lancet, The | 2019 | 697 |
| 19 | 2018 Update of the EULAR recommendations for the management of large vessel vasculitis | Annals of the Rheumatic Diseases | 2020 | 667 |
| 20 | Randomized, Placebo-Controlled Trial of Pioglitazone in Nondiabetic Subjects With Nonalcoholic Steatohepatitis | Gastroenterology | 2008 | 636 |
| 21 | Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trial | Lancet, The | 2008 | 620 |
| 22 | UK clinical guideline for the prevention and treatment of osteoporosis | Archives of Osteoporosis | 2017 | 609 |
| 23 | Association Between Fibrosis Stage and Outcomes of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis | Gastroenterology | 2020 | 575 |
| 24 | Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial | Lancet, The | 2021 | 540 |
| 25 | Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary | European Respiratory Journal | 2017 | 536 |
| 26 | Impact of surgical site infection on healthcare costs and patient outcomes: a systematic review in six European countries | Journal of Hospital Infection | 2017 | 532 |
| 27 | Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial | Lancet, The | 2021 | 519 |
| 28 | UK guidelines on the management of variceal haemorrhage in cirrhotic patients | Gut | 2015 | 518 |
| 29 | The rare coagulation disorders - review with guidelines for management from the United Kingdom Haemophilia Centre Doctors' Organisation | Haemophilia | 2004 | 516 |
| 30 | European Resuscitation Council Guidelines 2021: Adult advanced life support | Resuscitation | 2021 | 513 |
| 31 | Sjögren syndrome | Nature Reviews Disease Primers | 2016 | 511 |
| 32 | Benchmarking Complications Associated with Esophagectomy | Annals of Surgery | 2019 | 504 |
| 33 | The Southampton Consensus Guidelines for Laparoscopic Liver Surgery | Annals of Surgery | 2018 | 488 |
| 34 | COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study | Lancet Oncology, The | 2020 | 473 |
| 35 | Systematic review with meta‐analysis: the efficacy of faecal microbiota transplantation for the treatment of recurrent and refractory Clostridium difficile infection | Alimentary Pharmacology and Therapeutics | 2017 | 455 |
| 36 | Brentuximab vedotin or physician's choice in CD30-positive cutaneous T-cell lymphoma (ALCANZA): an international, open-label, randomised, phase 3, multicentre trial | Lancet, The | 2017 | 444 |
| 37 | The impact of ethnicity on clinical outcomes in COVID-19: A systematic review | EClinicalMedicine | 2020 | 442 |
| 38 | Mitomycin, Ifosfamide, and Cisplatin in Unresectable Non–Small-Cell Lung Cancer: Effects on Survival and Quality of Life | Journal of Clinical Oncology | 1999 | 430 |
| 39 | Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial | Lancet, The | 2021 | 430 |
| 40 | Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome | Nature Genetics | 2013 | 427 |
| 41 | European Consensus on the Diagnosis and Management of Iron Deficiency and Anaemia in Inflammatory Bowel Diseases | Journal of Crohn's and Colitis | 2015 | 425 |
| 42 | Is ethnicity linked to incidence or outcomes of covid-19? | BMJ, The | 2020 | 408 |
| 43 | Pressure ulcer prevalence in Europe: a pilot study | Journal of Evaluation in Clinical Practice | 2007 | 403 |
| 44 | Mogamulizumab versus vorinostat in previously treated cutaneous T-cell lymphoma (MAVORIC): an international, open-label, randomised, controlled phase 3 trial | Lancet Oncology, The | 2018 | 398 |
| 45 | Official ERS technical standards: Global Lung Function Initiative reference values for the carbon monoxide transfer factor for Caucasians | European Respiratory Journal | 2017 | 394 |
| 46 | Ethnicity and COVID-19: an urgent public health research priority | Lancet, The | 2020 | 388 |
| 47 | Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial | American Journal of Transplantation | 2016 | 386 |
| 48 | A No-Prophylaxis Platelet-Transfusion Strategy for Hematologic Cancers | New England Journal of Medicine | 2013 | 384 |
| 49 | EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI): development of a consensus patient index for primary Sjögren's syndrome | Annals of the Rheumatic Diseases | 2011 | 383 |
| 50 | Use and interpretation of diagnostic vaccination in primary immunodeficiency: A working group report of the Basic and Clinical Immunology Interest Section of the American Academy of Allergy, Asthma & Immunology | Journal of Allergy and Clinical Immunology | 2012 | 379 |
