| # | Title | Journal | Year | Citations |
|---|
| 1 | Niraparib in Patients with Newly Diagnosed Advanced Ovarian Cancer | New England Journal of Medicine | 2019 | 1,337 |
| 2 | Outcomes associated with drug-eluting and bare-metal stents: a collaborative network meta-analysis | Lancet, The | 2007 | 1,329 |
| 3 | 5-year analysis of neoadjuvant pertuzumab and trastuzumab in patients with locally advanced, inflammatory, or early-stage HER2-positive breast cancer (NeoSphere): a multicentre, open-label, phase 2 randomised trial | Lancet Oncology, The | 2016 | 623 |
| 4 | Neoadjuvant chemotherapy and nivolumab in resectable non-small-cell lung cancer (NADIM): an open-label, multicentre, single-arm, phase 2 trial | Lancet Oncology, The | 2020 | 475 |
| 5 | Epigenetic regulation of microRNA expression in colorectal cancer | International Journal of Cancer | 2009 | 418 |
| 6 | Frontal fibrosing alopecia: A multicenter review of 355 patients | Journal of the American Academy of Dermatology | 2014 | 362 |
| 7 | Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry (Registro Espanol de Acromegalia, REA) | European Journal of Endocrinology | 2004 | 334 |
| 8 | 2018 Annual Report of the European Liver Transplant Registry (ELTR) - 50-year evolution of liver transplantation | Transplant International | 2018 | 325 |
| 9 | Hemoglobin Variability Does Not Predict Mortality in European Hemodialysis Patients | Journal of the American Society of Nephrology: JASN | 2010 | 319 |
| 10 | Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility | Nature Genetics | 2009 | 313 |
| 11 | A Meta-Analysis of 16 Randomized Trials of Sirolimus-Eluting Stents Versus Paclitaxel-Eluting Stents in Patients With Coronary Artery Disease | Journal of the American College of Cardiology | 2007 | 307 |
| 12 | Epigenetic Silencing of the Tumor Suppressor MicroRNAHsa-miR-124aRegulates CDK6 Expression and Confers a Poor Prognosis in Acute Lymphoblastic Leukemia | Cancer Research | 2009 | 299 |
| 13 | Drug eluting and bare metal stents in people with and without diabetes: collaborative network meta-analysis | BMJ: British Medical Journal | 2008 | 270 |
| 14 | Dietary, physiological, genetic and pathological influences on postprandial lipid metabolism | British Journal of Nutrition | 2007 | 267 |
| 15 | NK phenotypic markers and IL2 response in NK cells from elderly people | Experimental Gerontology | 1999 | 261 |
| 16 | Classification of coronary artery bifurcation lesions and treatments: Time for a consensus! | Catheterization and Cardiovascular Interventions | 2008 | 260 |
| 17 | PROREPAIR-B: A Prospective Cohort Study of the Impact of Germline DNA Repair Mutations on the Outcomes of Patients With Metastatic Castration-Resistant Prostate Cancer | Journal of Clinical Oncology | 2019 | 255 |
| 18 | Tuberculosis after Solid‐Organ Transplant: Incidence, Risk Factors, and Clinical Characteristics in the RESITRA (Spanish Network of Infection in Transplantation) Cohort | Clinical Infectious Diseases | 2009 | 251 |
| 19 | Lurbinectedin as second-line treatment for patients with small-cell lung cancer: a single-arm, open-label, phase 2 basket trial | Lancet Oncology, The | 2020 | 247 |
| 20 | Cytomegalovirus in transplantation ? challenging the status quo | Clinical Transplantation | 2007 | 245 |
| 21 | Association Between Transcatheter Aortic Valve Replacement and Subsequent Infective Endocarditis and In-Hospital Death | JAMA - Journal of the American Medical Association | 2016 | 241 |
| 22 | Fast fibrosis progression between repeated liver biopsies in patients coinfected with human immunodeficiency virus/hepatitis C virus | Hepatology | 2009 | 233 |
| 23 | Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk | Circulation | 2020 | 232 |
| 24 | Terminal Complement Inhibitor Eculizumab in Adult Patients With Atypical Hemolytic Uremic Syndrome: A Single-Arm, Open-Label Trial | American Journal of Kidney Diseases | 2016 | 230 |
| 25 | Defining the Asthma-COPD Overlap Syndrome in a COPD Cohort | Chest | 2016 | 227 |
| 26 | Androgen receptor gene status in plasma DNA associates with worse outcome on enzalutamide or abiraterone for castration-resistant prostate cancer: a multi-institution correlative biomarker study | Annals of Oncology | 2017 | 213 |
| 27 | Thrombosis in primary antiphospholipid syndrome. A pivotal role for monocyte tissue factor expression | Arthritis and Rheumatism | 1997 | 204 |
| 28 | Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia | Blood | 2004 | 204 |
| 29 | Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia | Oncogene | 2005 | 202 |
| 30 | Safety of Thiopurines and Anti-TNF-α Drugs During Pregnancy in Patients With Inflammatory Bowel Disease | American Journal of Gastroenterology | 2013 | 197 |
| 31 | Normothermic regional perfusion vs. super-rapid recovery in controlled donation after circulatory death liver transplantation | Journal of Hepatology | 2019 | 193 |
| 32 | Impact of an Evidence-Based Bundle Intervention in the Quality-of-Care Management and Outcome of Staphylococcus aureus Bacteremia | Clinical Infectious Diseases | 2013 | 192 |
| 33 | Actualización en síndrome hemolítico urémico atípico: diagnóstico y tratamiento. Documento de consenso | Nefrologia | 2015 | 188 |
| 34 | Prevalence of comorbidities and evaluation of their screening in spondyloarthritis: results of the international cross-sectional ASAS-COMOSPA study | Annals of the Rheumatic Diseases | 2016 | 188 |
| 35 | Extracellular Vesicles Derived From Mesenchymal Stem Cells (MSC) in Regenerative Medicine: Applications in Skin Wound Healing | Frontiers in Bioengineering and Biotechnology | 2020 | 186 |
| 36 | Impact of Inadequate Empirical Therapy on the Mortality of Patients with Bloodstream Infections: a Propensity Score-Based Analysis | Antimicrobial Agents and Chemotherapy | 2012 | 182 |
| 37 | 5′ CpG island hypermethylation is associated with transcriptional silencing of the p21CIP1/WAF1/SDI1 gene and confers poor prognosis in acute lymphoblastic leukemia | Blood | 2002 | 171 |
| 38 | Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial | Lancet, The | 2022 | 169 |
| 39 | IFI44L promoter methylation as a blood biomarker for systemic lupus erythematosus | Annals of the Rheumatic Diseases | 2016 | 167 |
| 40 | Senescent CD14+CD16+ Monocytes Exhibit Proinflammatory and Proatherosclerotic Activity | Journal of Immunology | 2011 | 166 |
| 41 | Sildenafil for improving outcomes in patients with corrected valvular heart disease and persistent pulmonary hypertension: a multicenter, double-blind, randomized clinical trial | European Heart Journal | 2018 | 166 |
| 42 | Versión española del cuestionario de Yesavage abreviado (GDS) para el despistaje de depresión en mayores de 65 años: adaptación y validación | Medifam - Revista De Medicina Familiar Y Comunitaria | 2002 | 165 |
| 43 | Predicting the outcome of ankylosing spondylitis therapy | Annals of the Rheumatic Diseases | 2011 | 158 |
| 44 | Survival and prognostic factors of HIV-infected patients with HCV-related end-stage liver disease | Aids | 2006 | 154 |
| 45 | Ceftazidime-Avibactam as Salvage Therapy for Infections Caused by Carbapenem-Resistant Organisms | Antimicrobial Agents and Chemotherapy | 2017 | 149 |
| 46 | Extrathoracic Staging of Bronchogenic Carcinoma | Chest | 1990 | 146 |
| 47 | Ustekinumab for the Treatment of Refractory Crohnʼs Disease | Inflammatory Bowel Diseases | 2016 | 146 |
| 48 | Protective effect of dietary monounsaturated fat on arteriosclerosis: beyond cholesterol | Atherosclerosis | 2002 | 145 |
| 49 | A 5-Year Prospective Multicenter Evaluation of Influenza Infection in Transplant Recipients | Clinical Infectious Diseases | 2018 | 145 |
| 50 | “Very Early” Intrahepatic Cholangiocarcinoma in Cirrhotic Patients: Should Liver Transplantation Be Reconsidered in These Patients? | American Journal of Transplantation | 2014 | 143 |
