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Top Articles

#TitleJournalYearCitations
1Pembrolizumab plus Chemotherapy for Squamous Non–Small-Cell Lung CancerNew England Journal of Medicine20182,676
2Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV MelanomaNew England Journal of Medicine20171,752
3A molecular marker of artemisinin-resistant Plasmodium falciparum malariaNature20141,617
4Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trialLancet Oncology, The20151,269
5International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blastsBlood2015982
6A Double-Blind, Delayed-Start Trial of Rasagiline in Parkinson's DiseaseNew England Journal of Medicine2009830
7The I.A.N.A. task force on frailty assessment of older people in clinical practiceJournal of Nutrition, Health and Aging2008821
8Sarcopenia: Its assessment, etiology, pathogenesis, consequences and future perspectivesJournal of Nutrition, Health and Aging2008802
9Gilteritinib or Chemotherapy for Relapsed or Refractory FLT3-Mutated AMLNew England Journal of Medicine2019796
10Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trialLancet Neurology, The2011795
11European Respiratory Society guidelines for the management of adult bronchiectasisEuropean Respiratory Journal2017788
12Apelin, a Newly Identified Adipokine Up-Regulated by Insulin and ObesityEndocrinology2005761
13Frequency of Malnutrition in Older Adults: A Multinational Perspective Using the Mini Nutritional AssessmentJournal of the American Geriatrics Society2010746
14Early-Onset Autosomal Dominant Alzheimer Disease: Prevalence, Genetic Heterogeneity, and Mutation SpectrumAmerican Journal of Human Genetics1999696
15Daratumumab plus Lenalidomide and Dexamethasone for Untreated MyelomaNew England Journal of Medicine2019684
16Cognitive frailty: Rational and definition from an (I.A.N.A./I.A.G.G.) International Consensus GroupJournal of Nutrition, Health and Aging2013659
17Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO studyDiabetologia2020638
18Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability–High/Mismatch Repair–Deficient Metastatic Colorectal Cancer: KEYNOTE-164Journal of Clinical Oncology2020623
19Association of the Lung Immune Prognostic Index With Immune Checkpoint Inhibitor Outcomes in Patients With Advanced Non–Small Cell Lung CancerJAMA Oncology2018599
20Insertions and Duplications in the Polyproline Region of the Hepatitis E VirusFrontiers in Microbiology2020599
21Plasma Brain Natriuretic Peptide-Guided Therapy to Improve Outcome in Heart FailureJournal of the American College of Cardiology2007597
22Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative MetabolismCancer Discovery2017582
23Lung Cancer That Harbors an HER2 Mutation: Epidemiologic Characteristics and Therapeutic PerspectivesJournal of Clinical Oncology2013572
24A Wide Variety of Mutations in the Parkin Gene Are Responsible for Autosomal Recessive Parkinsonism in EuropeHuman Molecular Genetics1999571
25Weight loss regulates inflammation‐related genes in white adipose tissue of obese subjectsFASEB Journal2004569
26Hyperprogressive Disease in Patients With Advanced Non–Small Cell Lung Cancer Treated With PD-1/PD-L1 Inhibitors or With Single-Agent ChemotherapyJAMA Oncology2018567
27Addition of gemtuzumab ozogamicin to induction chemotherapy in adult patients with acute myeloid leukaemia: a meta-analysis of individual patient data from randomised controlled trialsLancet Oncology, The2014549
28International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and ManagementJournal of Nutrition, Health and Aging2018549
29Mild cognitive impairment (MCI) in medical practice: a critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer's DiseaseJournal of Neurology, Neurosurgery and Psychiatry2006539
30Short Physical Performance Battery and all-cause mortality: systematic review and meta-analysisBMC Medicine2016534
31The frailty phenotype and the frailty index: different instruments for different purposesAge and Ageing2014529
32Sirolimus and Secondary Skin-Cancer Prevention in Kidney TransplantationNew England Journal of Medicine2012520
33Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trialLancet, The2012517
34Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s DiseaseNew England Journal of Medicine2018512
35The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory CommitteeBlood2022512
36Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trialNature Medicine2000506
37Proposed diagnostic criteria for apathy in Alzheimer’s disease and other neuropsychiatric disordersEuropean Psychiatry2009504
38Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and ManagementJournal of Nutrition, Health and Aging2019474
39Flash Glucose-Sensing Technology as a Replacement for Blood Glucose Monitoring for the Management of Insulin-Treated Type 2 Diabetes: a Multicenter, Open-Label Randomized Controlled TrialDiabetes Therapy2017433
40Sex differences in metabolic regulation and diabetes susceptibilityDiabetologia2020423
41Pembrolizumab or Placebo Plus Etoposide and Platinum as First-Line Therapy for Extensive-Stage Small-Cell Lung Cancer: Randomized, Double-Blind, Phase III KEYNOTE-604 StudyJournal of Clinical Oncology2020410
42The Asia-Pacific Clinical Practice Guidelines for the Management of FrailtyJournal of the American Medical Directors Association2017408
43Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic StrokeJournal of Vascular and Interventional Radiology2018403
44Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephalyNature Genetics2013399
45Acquirement of Brown Fat Cell Features by Human White AdipocytesJournal of Biological Chemistry2003396
46TLR7 escapes X chromosome inactivation in immune cellsScience Immunology2018395
47Factor VIII Products and Inhibitor Development in Severe Hemophilia ANew England Journal of Medicine2013383
48Evidence for the Domains Supporting the Construct of Intrinsic CapacityJournals of Gerontology - Series A Biological Sciences and Medical Sciences2018366
49Bromodomain inhibitor OTX015 in patients with acute leukaemia: a dose-escalation, phase 1 studyLancet Haematology,the2016359
50Common brain disorders are associated with heritable patterns of apparent aging of the brainNature Neuroscience2019358