# | Title | Journal | Year | Citations |
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1 | Pembrolizumab plus Chemotherapy for Squamous Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2018 | 2,676 |
2 | Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV Melanoma | New England Journal of Medicine | 2017 | 1,752 |
3 | A molecular marker of artemisinin-resistant Plasmodium falciparum malaria | Nature | 2014 | 1,617 |
4 | Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial | Lancet Oncology, The | 2015 | 1,269 |
5 | International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts | Blood | 2015 | 982 |
6 | A Double-Blind, Delayed-Start Trial of Rasagiline in Parkinson's Disease | New England Journal of Medicine | 2009 | 830 |
7 | The I.A.N.A. task force on frailty assessment of older people in clinical practice | Journal of Nutrition, Health and Aging | 2008 | 821 |
8 | Sarcopenia: Its assessment, etiology, pathogenesis, consequences and future perspectives | Journal of Nutrition, Health and Aging | 2008 | 802 |
9 | Gilteritinib or Chemotherapy for Relapsed or Refractory FLT3-Mutated AML | New England Journal of Medicine | 2019 | 796 |
10 | Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial | Lancet Neurology, The | 2011 | 795 |
11 | European Respiratory Society guidelines for the management of adult bronchiectasis | European Respiratory Journal | 2017 | 788 |
12 | Apelin, a Newly Identified Adipokine Up-Regulated by Insulin and Obesity | Endocrinology | 2005 | 761 |
13 | Frequency of Malnutrition in Older Adults: A Multinational Perspective Using the Mini Nutritional Assessment | Journal of the American Geriatrics Society | 2010 | 746 |
14 | Early-Onset Autosomal Dominant Alzheimer Disease: Prevalence, Genetic Heterogeneity, and Mutation Spectrum | American Journal of Human Genetics | 1999 | 696 |
15 | Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma | New England Journal of Medicine | 2019 | 684 |
16 | Cognitive frailty: Rational and definition from an (I.A.N.A./I.A.G.G.) International Consensus Group | Journal of Nutrition, Health and Aging | 2013 | 659 |
17 | Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study | Diabetologia | 2020 | 638 |
18 | Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability–High/Mismatch Repair–Deficient Metastatic Colorectal Cancer: KEYNOTE-164 | Journal of Clinical Oncology | 2020 | 623 |
19 | Association of the Lung Immune Prognostic Index With Immune Checkpoint Inhibitor Outcomes in Patients With Advanced Non–Small Cell Lung Cancer | JAMA Oncology | 2018 | 599 |
20 | Insertions and Duplications in the Polyproline Region of the Hepatitis E Virus | Frontiers in Microbiology | 2020 | 599 |
21 | Plasma Brain Natriuretic Peptide-Guided Therapy to Improve Outcome in Heart Failure | Journal of the American College of Cardiology | 2007 | 597 |
22 | Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism | Cancer Discovery | 2017 | 582 |
23 | Lung Cancer That Harbors an HER2 Mutation: Epidemiologic Characteristics and Therapeutic Perspectives | Journal of Clinical Oncology | 2013 | 572 |
24 | A Wide Variety of Mutations in the Parkin Gene Are Responsible for Autosomal Recessive Parkinsonism in Europe | Human Molecular Genetics | 1999 | 571 |
25 | Weight loss regulates inflammation‐related genes in white adipose tissue of obese subjects | FASEB Journal | 2004 | 569 |
26 | Hyperprogressive Disease in Patients With Advanced Non–Small Cell Lung Cancer Treated With PD-1/PD-L1 Inhibitors or With Single-Agent Chemotherapy | JAMA Oncology | 2018 | 567 |
27 | Addition of gemtuzumab ozogamicin to induction chemotherapy in adult patients with acute myeloid leukaemia: a meta-analysis of individual patient data from randomised controlled trials | Lancet Oncology, The | 2014 | 549 |
28 | International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management | Journal of Nutrition, Health and Aging | 2018 | 549 |
29 | Mild cognitive impairment (MCI) in medical practice: a critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer's Disease | Journal of Neurology, Neurosurgery and Psychiatry | 2006 | 539 |
30 | Short Physical Performance Battery and all-cause mortality: systematic review and meta-analysis | BMC Medicine | 2016 | 534 |
31 | The frailty phenotype and the frailty index: different instruments for different purposes | Age and Ageing | 2014 | 529 |
32 | Sirolimus and Secondary Skin-Cancer Prevention in Kidney Transplantation | New England Journal of Medicine | 2012 | 520 |
33 | Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial | Lancet, The | 2012 | 517 |
34 | Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease | New England Journal of Medicine | 2018 | 512 |
35 | The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee | Blood | 2022 | 512 |
36 | Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial | Nature Medicine | 2000 | 506 |
37 | Proposed diagnostic criteria for apathy in Alzheimer’s disease and other neuropsychiatric disorders | European Psychiatry | 2009 | 504 |
38 | Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management | Journal of Nutrition, Health and Aging | 2019 | 474 |
39 | Flash Glucose-Sensing Technology as a Replacement for Blood Glucose Monitoring for the Management of Insulin-Treated Type 2 Diabetes: a Multicenter, Open-Label Randomized Controlled Trial | Diabetes Therapy | 2017 | 433 |
40 | Sex differences in metabolic regulation and diabetes susceptibility | Diabetologia | 2020 | 423 |
41 | Pembrolizumab or Placebo Plus Etoposide and Platinum as First-Line Therapy for Extensive-Stage Small-Cell Lung Cancer: Randomized, Double-Blind, Phase III KEYNOTE-604 Study | Journal of Clinical Oncology | 2020 | 410 |
42 | The Asia-Pacific Clinical Practice Guidelines for the Management of Frailty | Journal of the American Medical Directors Association | 2017 | 408 |
43 | Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic Stroke | Journal of Vascular and Interventional Radiology | 2018 | 403 |
44 | Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly | Nature Genetics | 2013 | 399 |
45 | Acquirement of Brown Fat Cell Features by Human White Adipocytes | Journal of Biological Chemistry | 2003 | 396 |
46 | TLR7 escapes X chromosome inactivation in immune cells | Science Immunology | 2018 | 395 |
47 | Factor VIII Products and Inhibitor Development in Severe Hemophilia A | New England Journal of Medicine | 2013 | 383 |
48 | Evidence for the Domains Supporting the Construct of Intrinsic Capacity | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2018 | 366 |
49 | Bromodomain inhibitor OTX015 in patients with acute leukaemia: a dose-escalation, phase 1 study | Lancet Haematology,the | 2016 | 359 |
50 | Common brain disorders are associated with heritable patterns of apparent aging of the brain | Nature Neuroscience | 2019 | 358 |