| # | Title | Journal | Year | Citations |
|---|
| 1 | Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2015 | 7,261 |
| 2 | Neuroinflammation in Alzheimer's disease | Lancet Neurology, The | 2015 | 4,129 |
| 3 | A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement | Journal of Hepatology | 2020 | 2,171 |
| 4 | Peginterferon Alfa-2a plus Ribavirin for Chronic Hepatitis C Virus Infection in HIV-Infected Patients | New England Journal of Medicine | 2004 | 1,220 |
| 5 | Sexual Activity Without Condoms and Risk of HIV Transmission in Serodifferent Couples When the HIV-Positive Partner Is Using Suppressive Antiretroviral Therapy | JAMA - Journal of the American Medical Association | 2016 | 1,076 |
| 6 | European Resuscitation Council Guidelines for Resuscitation 2015 | Resuscitation | 2015 | 937 |
| 7 | European Resuscitation Council Guidelines for Resuscitation 2010 Section 2. Adult basic life support and use of automated external defibrillators | Resuscitation | 2010 | 877 |
| 8 | Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer (ARCHER 1050): a randomised, open-label, phase 3 trial | Lancet Oncology, The | 2017 | 877 |
| 9 | Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma | New England Journal of Medicine | 2020 | 802 |
| 10 | Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study | Lancet Oncology, The | 2015 | 753 |
| 11 | Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis* | Critical Care Medicine | 2003 | 747 |
| 12 | The potential of melatonin in reducing morbidity?mortality after craniocerebral trauma | Journal of Pineal Research | 2007 | 713 |
| 13 | Breast cancer prognostic classification in the molecular era: the role of histological grade | Breast Cancer Research | 2010 | 650 |
| 14 | Human immunodeficiency virus infection modified the natural history of chronic parenterally-acquired hepatitis C with an unusually rapid progression to cirrhosis | Journal of Hepatology | 1997 | 596 |
| 15 | A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus | Nature Genetics | 2006 | 593 |
| 16 | Effect of CPAP on Blood Pressure in Patients With Obstructive Sleep Apnea and Resistant Hypertension | JAMA - Journal of the American Medical Association | 2013 | 567 |
| 17 | Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists | Modern Pathology | 2011 | 545 |
| 18 | Fibrosis Severity as a Determinant of Cause-Specific Mortality in Patients With Advanced Nonalcoholic Fatty Liver Disease: A Multi-National Cohort Study | Gastroenterology | 2018 | 536 |
| 19 | A shuttle walk test for assessment of functional capacity in chronic heart failure | American Heart Journal | 1999 | 526 |
| 20 | Durvalumab as third-line or later treatment for advanced non-small-cell lung cancer (ATLANTIC): an open-label, single-arm, phase 2 study | Lancet Oncology, The | 2018 | 486 |
| 21 | Neoadjuvant chemotherapy and nivolumab in resectable non-small-cell lung cancer (NADIM): an open-label, multicentre, single-arm, phase 2 trial | Lancet Oncology, The | 2020 | 475 |
| 22 | Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet Oncology, The | 2017 | 451 |
| 23 | Olive oil and health: Summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008 | Nutrition, Metabolism and Cardiovascular Diseases | 2010 | 449 |
| 24 | Treatment of Multidrug‐ResistantAcinetobacter baumanniiVentilator‐Associated Pneumonia (VAP) with Intravenous Colistin: A Comparison with Imipenem‐Susceptible VAP | Clinical Infectious Diseases | 2003 | 448 |
| 25 | Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus | Nature Genetics | 2008 | 436 |
| 26 | Fulvestrant 500 mg versus anastrozole 1 mg for hormone receptor-positive advanced breast cancer (FALCON): an international, randomised, double-blind, phase 3 trial | Lancet, The | 2016 | 435 |
| 27 | Community-Acquired Bloodstream Infection in Critically Ill Adult Patients | Chest | 2003 | 420 |
| 28 | A Randomized Trial of Factor VIII and Neutralizing Antibodies in Hemophilia A | New England Journal of Medicine | 2016 | 414 |
| 29 | 2nd ESMO Consensus Conference on Lung Cancer: early-stage non-small-cell lung cancer consensus on diagnosis, treatment and follow-up | Annals of Oncology | 2014 | 410 |
| 30 | Critical illness polyneuropathy: risk factors and clinical consequences. A cohort study in septic patients | Intensive Care Medicine | 2001 | 386 |
| 31 | Histotype-tailored neoadjuvant chemotherapy versus standard chemotherapy in patients with high-risk soft-tissue sarcomas (ISG-STS 1001): an international, open-label, randomised, controlled, phase 3, multicentre trial | Lancet Oncology, The | 2017 | 370 |
| 32 | Improvement in Overall Survival in a Randomized Study That Compared Dacomitinib With Gefitinib in Patients With Advanced Non–Small-Cell Lung Cancer and EGFR-Activating Mutations | Journal of Clinical Oncology | 2018 | 361 |
| 33 | Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus | Nature Genetics | 2010 | 351 |
| 34 | Transfusion of Blood Components and Postoperative Infection in Patients Undergoing Cardiac Surgery | Chest | 2001 | 348 |
| 35 | Survival in pulmonary hypertension in Spain: insights from the Spanish registry | European Respiratory Journal | 2012 | 342 |
| 36 | Truncating FLNC Mutations Are Associated With High-Risk Dilated and Arrhythmogenic Cardiomyopathies | Journal of the American College of Cardiology | 2016 | 340 |
| 37 | Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes | New England Journal of Medicine | 2020 | 335 |
| 38 | Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry (Registro Espanol de Acromegalia, REA) | European Journal of Endocrinology | 2004 | 334 |
| 39 | Effect of critical illness polyneuropathy on the withdrawal from mechanical ventilation and the length of stay in septic patients* | Critical Care Medicine | 2005 | 333 |
| 40 | De-escalation of empirical therapy is associated with lower mortality in patients with severe sepsis and septic shock | Intensive Care Medicine | 2014 | 333 |
| 41 | Advancing the global public health agenda for NAFLD: a consensus statement | Nature Reviews Gastroenterology and Hepatology | 2022 | 330 |
| 42 | Five-Year Outcomes From the Randomized, Phase III Trials CheckMate 017 and 057: Nivolumab Versus Docetaxel in Previously Treated Non–Small-Cell Lung Cancer | Journal of Clinical Oncology | 2021 | 329 |
| 43 | Durvalumab alone and durvalumab plus tremelimumab versus chemotherapy in previously untreated patients with unresectable, locally advanced or metastatic urothelial carcinoma (DANUBE): a randomised, open-label, multicentre, phase 3 trial | Lancet Oncology, The | 2020 | 324 |
| 44 | Severe Community-acquired Pneumonia: Etiology, Prognosis, and Treatment | The American Review of Respiratory Disease | 1990 | 319 |
| 45 | A Large Multicenter Study of Methicillin–Susceptible and Methicillin–Resistant Staphylococcus aureus Prosthetic Joint Infections Managed With Implant Retention | Clinical Infectious Diseases | 2013 | 319 |
| 46 | Bacteremia Due to Acinetobacter baumannii: Epidemiology, Clinical Findings, and Prognostic Features | Clinical Infectious Diseases | 1996 | 317 |
| 47 | Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza | Critical Care | 2009 | 316 |
| 48 | Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry: A worldwide collaborative project | Genetics in Medicine | 2011 | 308 |
| 49 | Causes and prognostic factors of remission induction failure in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and idarubicin | Blood | 2008 | 303 |
| 50 | Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn’s disease: results from a multicenter phase I/IIa clinical trial | International Journal of Colorectal Disease | 2013 | 302 |
