| # | Title | Journal | Year | Citations |
|---|
| 1 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 2 | Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci | Nature Genetics | 2018 | 652 |
| 3 | The early spread and epidemic ignition of HIV-1 in human populations | Science | 2014 | 515 |
| 4 | The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation | Intensive Care Medicine | 2011 | 482 |
| 5 | Characteristics of Secondary, Primary, and Compensated Hypogonadism in Aging Men: Evidence from the European Male Ageing Study | Journal of Clinical Endocrinology and Metabolism | 2010 | 481 |
| 6 | Serum levels of immunoglobulins (IgG, IgA, IgM) in a general adult population and their relationship with alcohol consumption, smoking and common metabolic abnormalities | Clinical and Experimental Immunology | 2007 | 480 |
| 7 | The risk of tuberculosis related to tumour necrosis factor antagonist therapies: a TBNET consensus statement | European Respiratory Journal | 2010 | 444 |
| 8 | Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis | Lancet Oncology, The | 2016 | 357 |
| 9 | Neuroendocrine Regulation and Actions of Leptin | Frontiers in Neuroendocrinology | 1999 | 345 |
| 10 | Ghrelin, A Novel Placental-Derived Hormone1 | Endocrinology | 2001 | 336 |
| 11 | Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline | Journal of Clinical Endocrinology and Metabolism | 2019 | 305 |
| 12 | Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer | Nature Genetics | 2017 | 289 |
| 13 | High Risk of Hypopituitarism after Traumatic Brain Injury: A Prospective Investigation of Anterior Pituitary Function in the Acute Phase and 12 Months after Trauma | Journal of Clinical Endocrinology and Metabolism | 2006 | 285 |
| 14 | Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses | Nature Genetics | 2020 | 265 |
| 15 | Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction | Nature Genetics | 2021 | 264 |
| 16 | Classification and heterogeneity of preterm birth | BJOG: an International Journal of Obstetrics and Gynaecology | 2003 | 233 |
| 17 | Classification and heterogeneity of preterm birth | BJOG: an International Journal of Obstetrics and Gynaecology | 2003 | 208 |
| 18 | Gender Differences in Both Spontaneous and Stimulated Leptin Secretion by Human Omental Adipose Tissue in Vitro: Dexamethasone and Estradiol Stimulate Leptin Release in Women, But Not in Men1 | Journal of Clinical Endocrinology and Metabolism | 1998 | 198 |
| 19 | Late-Onset Hypogonadism and Mortality in Aging Men | Journal of Clinical Endocrinology and Metabolism | 2014 | 184 |
| 20 | A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer | Nature Genetics | 2018 | 184 |
| 21 | Genetic insights into biological mechanisms governing human ovarian ageing | Nature | 2021 | 183 |
| 22 | The Etiology of Pleural Effusions in an Area With High Incidence of Tuberculosis | Chest | 1996 | 180 |
| 23 | GH-releasing hormone and GH-releasing peptide-6 for diagnostic testing in GH-deficient adults | Lancet, The | 2000 | 177 |
| 24 | Prevalence of hypopituitarism and growth hormone deficiency in adults long-term after severe traumatic brain injury | Clinical Endocrinology | 2005 | 173 |
| 25 | Comparison of a very low-calorie-ketogenic diet with a standard low-calorie diet in the treatment of obesity | Endocrine | 2014 | 167 |
| 26 | Body Composition Changes After Very-Low-Calorie Ketogenic Diet in Obesity Evaluated by 3 Standardized Methods | Journal of Clinical Endocrinology and Metabolism | 2017 | 160 |
| 27 | A universal definition of ARDS: the PaO2/FiO2 ratio under a standard ventilatory setting—a prospective, multicenter validation study | Intensive Care Medicine | 2013 | 158 |
| 28 | Pituitary Dysfunction After Traumatic Brain Injury: A Clinical and Pathophysiological Approach | Endocrine Reviews | 2015 | 154 |
| 29 | Quality of life after liver transplantation. A systematic review | Journal of Hepatology | 2008 | 148 |
| 30 | Maintenance therapy with bortezomib plus thalidomide or bortezomib plus prednisone in elderly multiple myeloma patients included in the GEM2005MAS65 trial | Blood | 2012 | 148 |
| 31 | Influence of Endogenous Leptin Tone on the Estrous Cycle and Luteinizing Hormone Pulsatility in Female Rats | Neuroendocrinology | 1997 | 142 |
| 32 | Genome-wide association study identifies multiple loci associated with bladder cancer risk | Human Molecular Genetics | 2014 | 137 |
| 33 | Performance Evaluation of the LabPET APD-Based Digital PET Scanner | IEEE Transactions on Nuclear Science | 2009 | 134 |
| 34 | Adenosine deaminase (ADA) isoenzyme analysis in pleural effusions: diagnostic role, and relevance to the origin of increased ADA in tuberculous pleurisy | European Respiratory Journal | 1996 | 131 |
| 35 | Novel Common Genetic Susceptibility Loci for Colorectal Cancer | Journal of the National Cancer Institute | 2019 | 129 |
| 36 | Ghrelin, A Novel Placental-Derived Hormone*This work was supported by grants from Xunta de Galicia: PGIDT99PXI20802B, PGIDT99PXI20806B, and Fondo de Investigación Sanitaria, Spanish Ministry of Health, and DGCYT. | Journal of the National Cancer Institute | 0 | 129 |
| 37 | Increased Estrogen Rather Than Decreased Androgen Action Is Associated with Longer Androgen Receptor CAG Repeats | Journal of Clinical Endocrinology and Metabolism | 2009 | 125 |
| 38 | The ability of three different models of frailty to predict all-cause mortality: Results from the European Male Aging Study (EMAS) | Archives of Gerontology and Geriatrics | 2013 | 121 |
| 39 | Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes | Nature Genetics | 2020 | 120 |
| 40 | Severe manifestations of SARS-CoV-2 in children and adolescents: from COVID-19 pneumonia to multisystem inflammatory syndrome: a multicentre study in pediatric intensive care units in Spain | Critical Care | 2020 | 120 |
| 41 | Nivolumab Plus Ipilimumab for Treatment-Naïve Metastatic Uveal Melanoma: An Open-Label, Multicenter, Phase II Trial by the Spanish Multidisciplinary Melanoma Group (GEM-1402) | Journal of Clinical Oncology | 2021 | 117 |
| 42 | A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1 | Nature Genetics | 2014 | 114 |
| 43 | Tocilizumab in giant cell arteritis: Multicenter open-label study of 22 patients | Seminars in Arthritis and Rheumatism | 2015 | 114 |
| 44 | Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats | Journal of Endocrinological Investigation | 2006 | 112 |
| 45 | Normativa sobre el diagnóstico y tratamiento del derrame pleural. Actualización | Archivos De Bronconeumologia | 2014 | 110 |
| 46 | Nacystelyn, a novel lysine salt of N-acetylcysteine, to augment cellular antioxidant defence in vitro | Respiratory Medicine | 1997 | 108 |
| 47 | An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels | Pharmacopsychiatry | 2022 | 107 |
| 48 | The Relationships between Sex Hormones and Sexual Function in Middle-Aged and Older European Men | Journal of Clinical Endocrinology and Metabolism | 2011 | 103 |
| 49 | Minor complications arising in alveolar distraction osteogenesis | Journal of Oral and Maxillofacial Surgery | 2002 | 100 |
| 50 | Associations Between Sex Steroids and the Development of Metabolic Syndrome: A Longitudinal Study in European Men | Journal of Clinical Endocrinology and Metabolism | 2015 | 97 |
