| # | Title | Journal | Year | Citations |
|---|
| 1 | Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID-19) Epidemic among the General Population in China | International Journal of Environmental Research and Public Health | 2020 | 6,765 |
| 2 | Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040 | Ophthalmology | 2014 | 4,514 |
| 3 | Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis | The Lancet Global Health | 2014 | 3,277 |
| 4 | The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status | Military Medical Research | 2020 | 2,937 |
| 5 | Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update | Hepatology International | 2016 | 1,908 |
| 6 | International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma | Lancet Oncology, The | 2016 | 1,866 |
| 7 | The epidemiology of obesity | Metabolism: Clinical and Experimental | 2019 | 1,603 |
| 8 | Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA | Nature | 2013 | 1,443 |
| 9 | A multinational, multicentre study on the psychological outcomes and associated physical symptoms amongst healthcare workers during COVID-19 outbreak | Brain, Behavior, and Immunity | 2020 | 1,165 |
| 10 | Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes | Nature Genetics | 2018 | 1,124 |
| 11 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 12 | Correlates, facilitators and barriers of physical activity among primary care patients with prediabetes in Singapore – a mixed methods approach | BMC Public Health | 2020 | 1,080 |
| 13 | A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2–spike protein–protein interaction | Nature Biotechnology | 2020 | 1,042 |
| 14 | Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19 | JAMA - Journal of the American Medical Association | 2020 | 1,032 |
| 15 | The genetic architecture of type 2 diabetes | Nature | 2016 | 952 |
| 16 | Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae , an urgent threat to public health | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 942 |
| 17 | Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention | Nature Reviews Gastroenterology and Hepatology | 2021 | 867 |
| 18 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014 | Hepatology International | 2014 | 861 |
| 19 | Do psychiatric patients experience more psychiatric symptoms during COVID-19 pandemic and lockdown? A case-control study with service and research implications for immunopsychiatry | Brain, Behavior, and Immunity | 2020 | 773 |
| 20 | Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: A meta-analysis and meta-regression | Journal of Affective Disorders | 2012 | 759 |
| 21 | Can we contain the COVID-19 outbreak with the same measures as for SARS? | Lancet Infectious Diseases, The | 2020 | 693 |
| 22 | Projecting social contact matrices in 152 countries using contact surveys and demographic data | PLoS Computational Biology | 2017 | 666 |
| 23 | Malnutrition and its impact on cost of hospitalization, length of stay, readmission and 3-year mortality | Clinical Nutrition | 2012 | 663 |
| 24 | Mental Health Strategies to Combat the Psychological Impact of Coronavirus Disease 2019 (COVID-19) Beyond Paranoia and Panic | Annals of the Academy of Medicine, Singapore | 2020 | 659 |
| 25 | Extracorporeal membrane oxygenation support in COVID-19: an international cohort study of the Extracorporeal Life Support Organization registry | Lancet, The | 2020 | 656 |
| 26 | Epithelial‐mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients | EMBO Molecular Medicine | 2014 | 612 |
| 27 | Rapid Whole-Genome Sequencing for Investigation of a Neonatal MRSA Outbreak | New England Journal of Medicine | 2012 | 609 |
| 28 | A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets | Gut | 2012 | 562 |
| 29 | DIA-Umpire: comprehensive computational framework for data-independent acquisition proteomics | Nature Methods | 2015 | 561 |
| 30 | International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management | Journal of Nutrition, Health and Aging | 2018 | 549 |
| 31 | A catalog of genetic loci associated with kidney function from analyses of a million individuals | Nature Genetics | 2019 | 549 |
| 32 | Diagnostic Criteria for Vascular Cognitive Disorders | Alzheimer Disease and Associated Disorders | 2014 | 529 |
| 33 | Mental Health Strategies to Combat the Psychological Impact of Coronavirus Disease 2019 (COVID-19) Beyond Paranoia and Panic | Annals of the Academy of Medicine, Singapore | 2020 | 526 |
| 34 | Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer | Nature Genetics | 2015 | 513 |
| 35 | Autologous Bone Marrow–Derived Mesenchymal Stem Cells Versus Autologous Chondrocyte Implantation | American Journal of Sports Medicine | 2010 | 510 |
| 36 | A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer | Nature Medicine | 2012 | 510 |
| 37 | SAINTexpress: Improvements and additional features in Significance Analysis of INTeractome software | Journal of Proteomics | 2014 | 501 |
| 38 | Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk | Nature Genetics | 2017 | 492 |
| 39 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update | Hepatology International | 2019 | 483 |
| 40 | Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management | Journal of Nutrition, Health and Aging | 2019 | 474 |
| 41 | Choroidal vascularity index as a measure of vascular status of the choroid: Measurements in healthy eyes from a population-based study | Scientific Reports | 2016 | 468 |
| 42 | Loss-of-function mutations in SLC30A8 protect against type 2 diabetes | Nature Genetics | 2014 | 428 |
| 43 | Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update | Clinical Pharmacology and Therapeutics | 2019 | 428 |
| 44 | The Global Prevalence of Anxiety Among Medical Students: A Meta-Analysis | International Journal of Environmental Research and Public Health | 2019 | 416 |
| 45 | Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions | Science Signaling | 2013 | 411 |
| 46 | Genome-wide associations for birth weight and correlations with adult disease | Nature | 2016 | 406 |
| 47 | Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors | Nature Genetics | 2019 | 402 |
| 48 | Role of 18F-FDG PET/CT in the diagnosis and management of multiple myeloma and other plasma cell disorders: a consensus statement by the International Myeloma Working Group | Lancet Oncology, The | 2017 | 394 |
| 49 | NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity | Nature Genetics | 2016 | 389 |
| 50 | Are high-performing health systems resilient against the COVID-19 epidemic? | Lancet, The | 2020 | 386 |
