| # | Title | Journal | Year | Citations |
|---|
| 1 | Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial | Lancet, The | 2020 | 2,080 |
| 2 | British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults | Gut | 2019 | 1,353 |
| 3 | Outcomes after Transplantation of Cord Blood or Bone Marrow from Unrelated Donors in Adults with Leukemia | New England Journal of Medicine | 2004 | 1,019 |
| 4 | Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock* | Critical Care Medicine | 2004 | 948 |
| 5 | Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial | Journal of Clinical Oncology | 2013 | 820 |
| 6 | Guidelines for enhanced recovery after lung surgery: recommendations of the Enhanced Recovery After Surgery (ERAS®) Society and the European Society of Thoracic Surgeons (ESTS) | European Journal of Cardio-thoracic Surgery | 2019 | 749 |
| 7 | Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study | Blood | 2007 | 716 |
| 8 | Magnetic Resonance Imaging for the Detection, Localisation, and Characterisation of Prostate Cancer: Recommendations from a European Consensus Meeting | European Urology | 2011 | 642 |
| 9 | Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial | Lancet, The | 2021 | 540 |
| 10 | Fractional flow reserve versus angiography for guidance of PCI in patients with multivessel coronary artery disease (FAME): 5-year follow-up of a randomised controlled trial | Lancet, The | 2015 | 455 |
| 11 | Suicide trends in the early months of the COVID-19 pandemic: an interrupted time-series analysis of preliminary data from 21 countries | Lancet Psychiatry,the | 2021 | 455 |
| 12 | European Society of Cardiology, acute cardiovascular care association, SCAD study group: a position paper on spontaneous coronary artery dissection | European Heart Journal | 2018 | 421 |
| 13 | Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders | Nature Neuroscience | 2016 | 388 |
| 14 | Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study | Journal of Allergy and Clinical Immunology | 2017 | 377 |
| 15 | Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial | Lancet Oncology, The | 2014 | 371 |
| 16 | Indications for Autologous and Allogeneic Hematopoietic Cell Transplantation: Guidelines from the American Society for Blood and Marrow Transplantation | Biology of Blood and Marrow Transplantation | 2015 | 342 |
| 17 | High Rate of Recurrent De Novo Mutations in Developmental and Epileptic Encephalopathies | American Journal of Human Genetics | 2017 | 337 |
| 18 | Immediate versus deferred chemotherapy after radical cystectomy in patients with pT3–pT4 or N+ M0 urothelial carcinoma of the bladder (EORTC 30994): an intergroup, open-label, randomised phase 3 trial | Lancet Oncology, The | 2015 | 323 |
| 19 | Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal disease | Gut | 2000 | 314 |
| 20 | Effect of a Strategy of a Supraglottic Airway Device vs Tracheal Intubation During Out-of-Hospital Cardiac Arrest on Functional Outcome | JAMA - Journal of the American Medical Association | 2018 | 290 |
| 21 | Gefitinib for oesophageal cancer progressing after chemotherapy (COG): a phase 3, multicentre, double-blind, placebo-controlled randomised trial | Lancet Oncology, The | 2014 | 270 |
| 22 | A prospective randomized evaluation of the TriGuard™ HDH embolic DEFLECTion device during transcatheter aortic valve implantation: results from the DEFLECT III trial | European Heart Journal | 2015 | 259 |
| 23 | Acute Cardiovascular Manifestations in 286 Children With Multisystem Inflammatory Syndrome Associated With COVID-19 Infection in Europe | Circulation | 2021 | 253 |
| 24 | Guidelines for the diagnosis and management of multiple myeloma 2011 | British Journal of Haematology | 2011 | 252 |
| 25 | Reporting of Short-Term Clinical Outcomes After Esophagectomy | Annals of Surgery | 2012 | 243 |
| 26 | Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD | Gut | 2021 | 233 |
| 27 | British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic | Gut | 2020 | 232 |
| 28 | Management of adults and children undergoing chimeric antigen receptor T-cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) | Haematologica | 2020 | 230 |
| 29 | Voriconazole versus itraconazole for antifungal prophylaxis following allogeneic haematopoietic stem‐cell transplantation | British Journal of Haematology | 2011 | 205 |
| 30 | Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH): a multicentre, multicohort, phase 2a, platform trial | Lancet Oncology, The | 2020 | 196 |
| 31 | Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose-escalation study | Nature Medicine | 2020 | 187 |
| 32 | The global burden of falls: global, regional and national estimates of morbidity and mortality from the Global Burden of Disease Study 2017 | Injury Prevention | 2020 | 185 |
| 33 | Trends in suicide during the covid-19 pandemic | BMJ, The | 2020 | 184 |
| 34 | Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis | Ophthalmology | 2018 | 178 |
| 35 | PATHOS: a phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV) positive oropharyngeal cancer | BMC Cancer | 2015 | 171 |
| 36 | Disease activity, severity, and damage in the UK juvenile‐onset systemic lupus erythematosus cohort | Arthritis and Rheumatism | 2012 | 170 |
| 37 | The impact of enhanced recovery after surgery (ERAS) protocol compliance on morbidity from resection for primary lung cancer | Journal of Thoracic and Cardiovascular Surgery | 2018 | 170 |
| 38 | Effect of Convalescent Plasma on Organ Support–Free Days in Critically Ill Patients With COVID-19 | JAMA - Journal of the American Medical Association | 2021 | 169 |
| 39 | Macrophage activation syndrome in adults: recent advances in pathophysiology, diagnosis and treatment | Rheumatology | 2019 | 167 |
| 40 | HLA-DQA1–HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants | Nature Genetics | 2014 | 165 |
| 41 | Acute skin toxicity associated with a 1-week schedule of whole breast radiotherapy compared with a standard 3-week regimen delivered in the UK FAST-Forward Trial | Radiotherapy and Oncology | 2016 | 165 |
| 42 | Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer | Nature Genetics | 2016 | 164 |
| 43 | Effects of on- and off-pump coronary artery surgery on graft patency, survival, and health-related quality of life: Long-term follow-up of 2 randomized controlled trials | Journal of Thoracic and Cardiovascular Surgery | 2009 | 161 |
| 44 | Outcomes in older adults with acute lymphoblastic leukaemia (ALL): results from the international MRC UKALL XII/ECOG2993 trial | British Journal of Haematology | 2012 | 161 |
| 45 | Hepatic adverse event profile of inotuzumab ozogamicin in adult patients with relapsed or refractory acute lymphoblastic leukaemia: results from the open-label, randomised, phase 3 INO-VATE study | Lancet Haematology,the | 2017 | 158 |
| 46 | Treatment of childhood obesity by retraining eating behaviour: randomised controlled trial | BMJ: British Medical Journal | 2009 | 156 |
| 47 | Whole systems approaches to obesity and other complex public health challenges: a systematic review | BMC Public Health | 2019 | 152 |
| 48 | Survival of Male Patients with Incontinentia Pigmenti Carrying a Lethal Mutation Can Be Explained by Somatic Mosaicism or Klinefelter Syndrome | American Journal of Human Genetics | 2001 | 150 |
| 49 | Prognosis of the infected diabetic foot ulcer: a 12‐month prospective observational study | Diabetic Medicine | 2018 | 150 |
| 50 | Best practice management guidelines for fibrous dysplasia/McCune-Albright syndrome: a consensus statement from the FD/MAS international consortium | Orphanet Journal of Rare Diseases | 2019 | 149 |
