| # | Title | Journal | Year | Citations |
|---|
| 1 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit | Critical Care Medicine | 2013 | 3,066 |
| 2 | Rejuvenation of aged progenitor cells by exposure to a young systemic environment | Nature | 2005 | 1,926 |
| 3 | Neuropathology of Parkinsonʼs Disease | Journal of Neuropathology and Experimental Neurology | 1996 | 1,253 |
| 4 | Robot-assisted movement training compared with conventional therapy techniques for the rehabilitation of upper-limb motor function after stroke | Archives of Physical Medicine and Rehabilitation | 2002 | 993 |
| 5 | The primary care PTSD screen (PC–PTSD): development and operating characteristics | Primary Care and Community Psychiatry | 2004 | 976 |
| 6 | SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin | Nature | 2008 | 945 |
| 7 | Brief interventions for alcohol problems: a meta-analytic review of controlled investigations in treatment-seeking and non-treatment-seeking populations | Addiction | 2002 | 938 |
| 8 | Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits | Nature Genetics | 2018 | 924 |
| 9 | The alliance in adult psychotherapy: A meta-analytic synthesis. | Psychotherapy | 2018 | 908 |
| 10 | 2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease | European Heart Journal | 2021 | 830 |
| 11 | A Model of the Upper Extremity for Simulating Musculoskeletal Surgery and Analyzing Neuromuscular Control | Annals of Biomedical Engineering | 2005 | 810 |
| 12 | Adult mouse astrocytes degrade amyloid-β in vitro and in situ | Nature Medicine | 2003 | 808 |
| 13 | DNA methylation-based measures of biological age: meta-analysis predicting time to death | Aging | 2016 | 786 |
| 14 | The Primary Care PTSD Screen for DSM-5 (PC-PTSD-5): Development and Evaluation Within a Veteran Primary Care Sample | Journal of General Internal Medicine | 2016 | 758 |
| 15 | Parenteral Anticoagulants | Chest | 2008 | 674 |
| 16 | Comparison of kindreds with parkinsonism and ?-synuclein genomic multiplications | Annals of Neurology | 2004 | 664 |
| 17 | Diversity and clonal selection in the human T-cell repertoire | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 622 |
| 18 | Clinical Recommendations for Cardiopulmonary Exercise Testing Data Assessment in Specific Patient Populations | Circulation | 2012 | 596 |
| 19 | The pancreatic stellate cell: a star on the rise in pancreatic diseases | Journal of Clinical Investigation | 2007 | 588 |
| 20 | The International Trauma Questionnaire: development of a self‐report measure of ICD‐11 PTSD and complex PTSD | Acta Psychiatrica Scandinavica | 2018 | 568 |
| 21 | Assessment of Clinical Performance during Simulated Crises Using Both Technical and Behavioral Ratings | Anesthesiology | 1998 | 501 |
| 22 | Evaluation of Patients With Pulmonary Nodules: When Is It Lung Cancer? | Chest | 2007 | 470 |
| 23 | Exome-wide association study of plasma lipids in >300,000 individuals | Nature Genetics | 2017 | 470 |
| 24 | Internet use and stigmatized illness | Social Science and Medicine | 2005 | 457 |
| 25 | A theoretical analysis of the relative influences of peak BMD, age-related bone loss and menopause on the development of osteoporosis | Osteoporosis International | 2003 | 456 |
| 26 | Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis | Nature Genetics | 2020 | 445 |
| 27 | Prevalence of Barrett's esophagus in asymptomatic individuals | Gastroenterology | 2002 | 426 |
| 28 | Kappa coefficients in medical research | Statistics in Medicine | 2002 | 424 |
| 29 | Dissemination of evidence‐based psychological treatments for posttraumatic stress disorder in the Veterans Health Administration | Journal of Traumatic Stress | 2010 | 413 |
| 30 | p63 regulates proliferation and differentiation of developmentally mature keratinocytes | Genes and Development | 2006 | 412 |
| 31 | Relationship of Safety Climate and Safety Performance in Hospitals | Health Services Research | 2009 | 408 |
| 32 | Frontal Lobe Volume Loss Observed with Magnetic Resonance Imaging in Older Chronic Alcoholics | Alcoholism: Clinical and Experimental Research | 1997 | 388 |
| 33 | Peak VO2 and VE/VCO2 slope in patients with heart failure: a prognostic comparison | American Heart Journal | 2004 | 385 |
| 34 | Treatment of complex PTSD: Results of the ISTSS expert clinician survey on best practices | Journal of Traumatic Stress | 2011 | 383 |
| 35 | Longitudinal Changes in Magnetic Resonance Imaging Brain Volumes in Abstinent and Relapsed Alcoholics | Alcoholism: Clinical and Experimental Research | 1995 | 380 |
| 36 | Genetics of 35 blood and urine biomarkers in the UK Biobank | Nature Genetics | 2021 | 377 |
| 37 | Characterization of Connective Tissue Disease-Associated Pulmonary Arterial Hypertension From REVEAL | Chest | 2010 | 375 |
| 38 | Association between concurrent use of prescription opioids and benzodiazepines and overdose: retrospective analysis | BMJ: British Medical Journal | 2017 | 372 |
| 39 | Increasing rates of cardiac device infections among medicare beneficiaries: 1990–1999 | American Heart Journal | 2004 | 362 |
| 40 | Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones | Nutrition and Metabolism | 2010 | 356 |
| 41 | A bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues | Nature Communications | 2018 | 353 |
| 42 | The power of genetic diversity in genome-wide association studies of lipids | Nature | 2021 | 353 |
| 43 | Transbronchial Cryobiopsy: A New Tool for Lung Biopsies | Respiration | 2009 | 350 |
| 44 | Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations | Nature Communications | 2019 | 346 |
| 45 | Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM | Nature | 2022 | 343 |
| 46 | Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism | American Journal of Psychiatry | 2018 | 338 |
| 47 | Trans-ethnic association study of blood pressure determinants in over 750,000 individuals | Nature Genetics | 2019 | 328 |
| 48 | SNM Practice Guideline for Sodium 18F-Fluoride PET/CT Bone Scans 1.0 | Journal of Nuclear Medicine | 2010 | 327 |
| 49 | Most Patients With Cancer‐Associated Dermatomyositis Have Antibodies to Nuclear Matrix Protein NXP‐2 or Transcription Intermediary Factor 1γ | Arthritis and Rheumatism | 2013 | 325 |
| 50 | Military-Related Sexual Trauma Among Veterans Health Administration Patients Returning From Afghanistan and Iraq | American Journal of Public Health | 2010 | 315 |
