| # | Title | Journal | Year | Citations |
|---|
| 1 | The blockade of immune checkpoints in cancer immunotherapy | Nature Reviews Cancer | 2012 | 10,874 |
| 2 | Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer | New England Journal of Medicine | 2012 | 10,727 |
| 3 | Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer | New England Journal of Medicine | 2012 | 6,820 |
| 4 | The fundamental role of epigenetic events in cancer | Nature Reviews Genetics | 2002 | 4,872 |
| 5 | Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis | Nature | 2010 | 4,648 |
| 6 | STATs in cancer inflammation and immunity: a leading role for STAT3 | Nature Reviews Cancer | 2009 | 3,503 |
| 7 | High Frequency of Mutations of the PIK3CA Gene in Human Cancers | Science | 2004 | 3,048 |
| 8 | Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates | Journal of Clinical Oncology | 2010 | 2,667 |
| 9 | Association of PD-1, PD-1 Ligands, and Other Features of the Tumor Immune Microenvironment with Response to Anti–PD-1 Therapy | Clinical Cancer Research | 2014 | 2,050 |
| 10 | Epigenetic memory in induced pluripotent stem cells | Nature | 2010 | 2,011 |
| 11 | Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | 2016 | 1,861 |
| 12 | Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study | Lancet, The | 2011 | 1,748 |
| 13 | REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants | American Journal of Human Genetics | 2016 | 1,555 |
| 14 | Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab | Cell | 2017 | 1,515 |
| 15 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 16 | A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses | Nature Medicine | 2009 | 1,426 |
| 17 | Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1 | Cell | 2011 | 1,304 |
| 18 | Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial | Journal of Psychopharmacology | 2016 | 1,221 |
| 19 | Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours | Nature | 2003 | 1,196 |
| 20 | Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity | Current Opinion in Immunology | 2012 | 1,186 |
| 21 | The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints | Cancer Discovery | 2015 | 1,180 |
| 22 | Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies | Annals of Oncology | 2015 | 1,136 |
| 23 | Cholangiocarcinoma | Annals of Surgery | 2007 | 1,120 |
| 24 | Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts | Cancer Discovery | 2019 | 1,120 |
| 25 | RAF/RAS oncogenes and mismatch-repair status | Nature | 2002 | 1,110 |
| 26 | Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters | Nature Genetics | 2011 | 1,080 |
| 27 | Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts | Nature Genetics | 2009 | 1,076 |
| 28 | Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer | Nature | 2003 | 1,026 |
| 29 | Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449 | New England Journal of Medicine | 2009 | 951 |
| 30 | Pemigatinib for previously treated, locally advanced or metastatic cholangiocarcinoma: a multicentre, open-label, phase 2 study | Lancet Oncology, The | 2020 | 923 |
| 31 | Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer | PLoS Medicine | 2006 | 894 |
| 32 | Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment | Mayo Clinic Proceedings | 2016 | 832 |
| 33 | The telomere syndromes | Nature Reviews Genetics | 2012 | 816 |
| 34 | Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA | Nature | 2008 | 777 |
| 35 | Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma | Science | 2009 | 774 |
| 36 | Efficacy and Safety of Durvalumab in Locally Advanced or Metastatic Urothelial Carcinoma | JAMA Oncology | 2017 | 750 |
| 37 | Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures | Genome Biology | 2016 | 746 |
| 38 | Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 744 |
| 39 | Characterization of clonogenic multiple myeloma cells | Blood | 2004 | 738 |
| 40 | Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer | Cancer Discovery | 2017 | 706 |
| 41 | Regulation of Immune Responses by mTOR | Annual Review of Immunology | 2012 | 689 |
| 42 | Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function | Journal of Experimental Medicine | 2006 | 683 |
| 43 | Evidence for a Role of the PD-1:PD-L1 Pathway in Immune Resistance of HPV-Associated Head and Neck Squamous Cell Carcinoma | Cancer Research | 2013 | 678 |
| 44 | Cyclophosphamide and cancer: golden anniversary | Nature Reviews Clinical Oncology | 2009 | 675 |
| 45 | Functional normalization of 450k methylation array data improves replication in large cancer studies | Genome Biology | 2014 | 665 |
| 46 | LAG3 (CD223) as a cancer immunotherapy target | Immunological Reviews | 2017 | 664 |
| 47 | B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma | Journal of Experimental Medicine | 2006 | 638 |
| 48 | Targeting FLT3 mutations in AML: review of current knowledge and evidence | Leukemia | 2019 | 625 |
| 49 | Allelic Variation in Human Gene Expression | Science | 2002 | 618 |
| 50 | Hyaluronan Fragments Act as an Endogenous Danger Signal by Engaging TLR2 | Journal of Immunology | 2006 | 606 |
