| # | Title | Journal | Year | Citations |
|---|
| 1 | Oxidative DNA damage: mechanisms, mutation, and disease | FASEB Journal | 2003 | 2,603 |
| 2 | 10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer | New England Journal of Medicine | 2016 | 2,101 |
| 3 | Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial | Lancet, The | 2012 | 1,849 |
| 4 | Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2017 | 1,456 |
| 5 | Sedentary time in adults and the association with diabetes, cardiovascular disease and death: systematic review and meta-analysis | Diabetologia | 2012 | 1,371 |
| 6 | Oxidative DNA damage and disease: induction, repair and significance | Mutation Research - Reviews in Mutation Research | 2004 | 1,102 |
| 7 | Phase I Clinical Trial of Oral Curcumin | Clinical Cancer Research | 2004 | 1,097 |
| 8 | Acute Exacerbations of Chronic Obstructive Pulmonary Disease | American Journal of Respiratory and Critical Care Medicine | 2011 | 847 |
| 9 | Everolimus-Eluting Stents or Bypass Surgery for Left Main Coronary Artery Disease | New England Journal of Medicine | 2016 | 843 |
| 10 | SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses | Cell | 2022 | 788 |
| 11 | Randomized Trial of Complete Versus Lesion-Only Revascularization in Patients Undergoing Primary Percutaneous Coronary Intervention for STEMI and Multivessel Disease | Journal of the American College of Cardiology | 2015 | 662 |
| 12 | Cancer-related pain: a pan-European survey of prevalence, treatment, and patient attitudes | Annals of Oncology | 2009 | 650 |
| 13 | Effectiveness of the diabetes education and self management for ongoing and newly diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes: cluster randomised controlled trial | BMJ: British Medical Journal | 2008 | 617 |
| 14 | A 26-Week, Randomized, Parallel, Treat-to-Target Trial Comparing Insulin Detemir With NPH Insulin as Add-On Therapy to Oral Glucose-Lowering Drugs in Insulin-Naïve People With Type 2 Diabetes | Diabetes Care | 2006 | 605 |
| 15 | Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis | BMJ: British Medical Journal | 2010 | 584 |
| 16 | Thorax: the Cappuccino years | Thorax | 2013 | 570 |
| 17 | How clean is your probe? Microbiological assessment of ultrasound transducers in routine clinical use, and cost-effective ways to reduce contamination | Clinical Radiology | 2007 | 549 |
| 18 | Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients | Journal of Allergy and Clinical Immunology | 2012 | 546 |
| 19 | Meta‐analysis: colorectal and small bowel cancer risk in patients with Crohn's disease | Alimentary Pharmacology and Therapeutics | 2006 | 543 |
| 20 | Sulfonylurea Inadequacy: Efficacy of addition of insulin over 6 years in patients with type 2 diabetes in the U.K. Prospective Diabetes Study (UKPDS 57) | Diabetes Care | 2002 | 534 |
| 21 | Prevalence, pathogenesis, and causes of chronic cough | Lancet, The | 2008 | 524 |
| 22 | British Thoracic Society guideline on pulmonary rehabilitation in adults: accredited by NICE | Thorax | 2013 | 519 |
| 23 | Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial | Lancet, The | 2021 | 519 |
| 24 | Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens | Nature Genetics | 2014 | 505 |
| 25 | Blood Eosinophils to Direct Corticosteroid Treatment of Exacerbations of Chronic Obstructive Pulmonary Disease | American Journal of Respiratory and Critical Care Medicine | 2012 | 499 |
| 26 | Langerhans cell histiocytosis (LCH): Guidelines for diagnosis, clinical work‐up, and treatment for patients till the age of 18 years | Pediatric Blood and Cancer | 2013 | 496 |
| 27 | Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer | Nature Genetics | 2013 | 493 |
| 28 | Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus | Journal of the American Academy of Dermatology | 2008 | 464 |
| 29 | Guidance on the management of pain in older people | Age and Ageing | 2013 | 463 |
| 30 | Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium | Science | 2016 | 462 |
| 31 | Germline mutations in RAD51D confer susceptibility to ovarian cancer | Nature Genetics | 2011 | 460 |
| 32 | Ethnicity and clinical outcomes in COVID-19: A systematic review and meta-analysis | EClinicalMedicine | 2020 | 454 |
| 33 | Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy | Aids | 2014 | 453 |
| 34 | A Switch in the Expression of Embryonic EMT-Inducers Drives the Development of Malignant Melanoma | Cancer Cell | 2013 | 450 |
| 35 | Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1 | American Journal of Medical Genetics, Part A | 2015 | 447 |
| 36 | Prenatal exome sequencing analysis in fetal structural anomalies detected by ultrasonography (PAGE): a cohort study | Lancet, The | 2019 | 443 |
| 37 | The impact of ethnicity on clinical outcomes in COVID-19: A systematic review | EClinicalMedicine | 2020 | 442 |
| 38 | Rescue Angioplasty after Failed Thrombolytic Therapy for Acute Myocardial Infarction | New England Journal of Medicine | 2005 | 436 |
| 39 | Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies | Lancet Respiratory Medicine,the | 2016 | 433 |
| 40 | Trial of 2009 Influenza A (H1N1) Monovalent MF59-Adjuvanted Vaccine | New England Journal of Medicine | 2009 | 430 |
| 41 | Guidelines on the radical management of patients with lung cancer | Thorax | 2010 | 393 |
| 42 | Association of Sedentary Behaviour with Metabolic Syndrome: A Meta-Analysis | PLoS ONE | 2012 | 388 |
| 43 | Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration | British Journal of Cancer | 2004 | 387 |
| 44 | Safety and Efficacy of Bronchial Thermoplasty in Symptomatic, Severe Asthma | American Journal of Respiratory and Critical Care Medicine | 2007 | 387 |
| 45 | UK guidelines on the management of iron deficiency in pregnancy | British Journal of Haematology | 2012 | 375 |
| 46 | Validation of the Oxford classification of IgA nephropathy in cohorts with different presentations and treatments | Kidney International | 2014 | 373 |
| 47 | Consumption of the Putative Chemopreventive Agent Curcumin by Cancer Patients: Assessment of Curcumin Levels in the Colorectum and their Pharmacodynamic Consequences | Cancer Epidemiology Biomarkers and Prevention | 2005 | 372 |
| 48 | Intensity-modulated fractionated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): acute toxicity findings from an international, randomised, open-label, phase 3, non-inferiority trial | Lancet Oncology, The | 2019 | 362 |
| 49 | Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma | Nature Genetics | 2010 | 357 |
| 50 | Tremelimumab as second-line or third-line treatment in relapsed malignant mesothelioma (DETERMINE): a multicentre, international, randomised, double-blind, placebo-controlled phase 2b trial | Lancet Oncology, The | 2017 | 356 |
