| # | Title | Journal | Year | Citations |
|---|
| 1 | Definition and classification of cancer cachexia: an international consensus | Lancet Oncology, The | 2011 | 4,015 |
| 2 | Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK | Lancet, The | 2021 | 3,887 |
| 3 | Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis | New England Journal of Medicine | 2000 | 3,651 |
| 4 | Lapatinib plus Capecitabine for HER2-Positive Advanced Breast Cancer | New England Journal of Medicine | 2006 | 3,119 |
| 5 | Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 | JAMA - Journal of the American Medical Association | 2020 | 1,855 |
| 6 | Differential oestrogen receptor binding is associated with clinical outcome in breast cancer | Nature | 2012 | 1,655 |
| 7 | Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial | Lancet, The | 2016 | 1,570 |
| 8 | A Controlled Trial of Natalizumab for Relapsing Multiple Sclerosis | New England Journal of Medicine | 2003 | 1,199 |
| 9 | The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials | Lancet Oncology, The | 2013 | 1,141 |
| 10 | British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus | Gut | 2014 | 1,116 |
| 11 | Co-infections in people with COVID-19: a systematic review and meta-analysis | Journal of Infection | 2020 | 1,114 |
| 12 | BTS guidelines for the management of community acquired pneumonia in adults: update 2009 | Thorax | 2009 | 1,039 |
| 13 | Acute Exacerbation of Idiopathic Pulmonary Fibrosis. An International Working Group Report | American Journal of Respiratory and Critical Care Medicine | 2016 | 1,006 |
| 14 | The enhanced recovery after surgery (ERAS) pathway for patients undergoing major elective open colorectal surgery: A meta-analysis of randomized controlled trials | Clinical Nutrition | 2010 | 986 |
| 15 | Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials | Lancet, The | 2021 | 979 |
| 16 | Scoliosis Research Society—Schwab Adult Spinal Deformity Classification | Spine | 2012 | 976 |
| 17 | Guidelines of care for the management of atopic dermatitis | Journal of the American Academy of Dermatology | 2014 | 889 |
| 18 | Critical Care Management of Patients Following Aneurysmal Subarachnoid Hemorrhage: Recommendations from the Neurocritical Care Society’s Multidisciplinary Consensus Conference | Neurocritical Care | 2011 | 886 |
| 19 | Predictors of Outcome in Patients With Acute Coronary Syndromes Without Persistent ST-Segment Elevation | Circulation | 2000 | 841 |
| 20 | The Effectiveness of Convalescent Plasma and Hyperimmune Immunoglobulin for the Treatment of Severe Acute Respiratory Infections of Viral Etiology: A Systematic Review and Exploratory Meta-analysis | Journal of Infectious Diseases | 2015 | 841 |
| 21 | Modification and validation of the Birmingham Vasculitis Activity Score (version 3) | Annals of the Rheumatic Diseases | 2009 | 825 |
| 22 | Acne vulgaris | Lancet, The | 2012 | 799 |
| 23 | Acinetobacter baumannii: evolution of a global pathogen | Pathogens and Disease | 2014 | 758 |
| 24 | A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses | Breast Cancer Research and Treatment | 2008 | 732 |
| 25 | The STROCSS statement: Strengthening the Reporting of Cohort Studies in Surgery | International Journal of Surgery | 2017 | 727 |
| 26 | A Comparison of Omeprazole with Ranitidine for Ulcers Associated with Nonsteroidal Antiinflammatory Drugs | New England Journal of Medicine | 1998 | 723 |
| 27 | Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study | Blood | 2007 | 716 |
| 28 | Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial | Lancet, The | 2019 | 697 |
| 29 | Guidelines on the irritable bowel syndrome: mechanisms and practical management | Gut | 2007 | 677 |
| 30 | Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial | Nature Medicine | 2018 | 649 |
| 31 | Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations | Clinical Nutrition | 2012 | 631 |
| 32 | British Thoracic Society guidelines for the investigation and management of pulmonary nodules: accredited by NICE | Thorax | 2015 | 631 |
| 33 | Targeting FLT3 mutations in AML: review of current knowledge and evidence | Leukemia | 2019 | 625 |
| 34 | International consensus statement on the peri‐operative management of anaemia and iron deficiency | Anaesthesia | 2017 | 571 |
| 35 | Consensus guidelines for enhanced recovery after gastrectomy | British Journal of Surgery | 2014 | 564 |
| 36 | Bacterial septic arthritis in adults | Lancet, The | 2010 | 541 |
| 37 | Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial | Lancet Oncology, The | 2015 | 536 |
| 38 | The definition of acute kidney injury and its use in practice | Kidney International | 2015 | 517 |
| 39 | The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials | Annals of the Rheumatic Diseases | 2008 | 506 |
| 40 | Polatuzumab Vedotin in Relapsed or Refractory Diffuse Large B-Cell Lymphoma | Journal of Clinical Oncology | 2020 | 488 |
| 41 | The worldwide incidence and prevalence of systemic lupus erythematosus: a systematic review of epidemiological studies | Rheumatology | 2017 | 487 |
| 42 | Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germlineCDH1mutation carriers | Journal of Medical Genetics | 2015 | 479 |
| 43 | The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized phase II/III trial | International Journal of Cancer | 2010 | 464 |
| 44 | Guidance on the management of pain in older people | Age and Ageing | 2013 | 463 |
| 45 | Prognostic Significance of Nottingham Histologic Grade in Invasive Breast Carcinoma | Journal of Clinical Oncology | 2008 | 462 |
| 46 | Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium | Science | 2016 | 462 |
| 47 | Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1 | American Journal of Medical Genetics, Part A | 2015 | 447 |
| 48 | Effect of palliative oxygen versus room air in relief of breathlessness in patients with refractory dyspnoea: a double-blind, randomised controlled trial | Lancet, The | 2010 | 434 |
| 49 | Guidelines for perioperative care for pancreaticoduodenectomy: Enhanced Recovery After Surgery (ERAS®) Society recommendations | Clinical Nutrition | 2012 | 429 |
| 50 | European position statement on lung cancer screening | Lancet Oncology, The | 2017 | 428 |
