| # | Title | Journal | Year | Citations |
|---|
| 1 | The Multimodal Brain Tumor Image Segmentation Benchmark (BRATS) | IEEE Transactions on Medical Imaging | 2015 | 3,589 |
| 2 | Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders | Lancet, The | 2005 | 3,100 |
| 3 | The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma | American Journal of Surgical Pathology | 2005 | 2,334 |
| 4 | Gastric cancer | Lancet, The | 2020 | 2,084 |
| 5 | Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee | Journal of Bone and Mineral Research | 2013 | 2,023 |
| 6 | A Phase 3 Trial of Bevacizumab in Ovarian Cancer | New England Journal of Medicine | 2011 | 1,843 |
| 7 | Regulatory T cells mediate maternal tolerance to the fetus | Nature Immunology | 2004 | 1,412 |
| 8 | The Life History of 21 Breast Cancers | Cell | 2012 | 1,249 |
| 9 | Genomic atlas of the human plasma proteome | Nature | 2018 | 1,180 |
| 10 | JAK2Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis | New England Journal of Medicine | 2007 | 1,173 |
| 11 | Hierarchical Organization of Human Cortical Networks in Health and Schizophrenia | Journal of Neuroscience | 2008 | 1,138 |
| 12 | British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus | Gut | 2014 | 1,116 |
| 13 | Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force | Annals of the Rheumatic Diseases | 2016 | 1,114 |
| 14 | Intelligence and the Frontal Lobe: The Organization of Goal-Directed Behavior | Cognitive Psychology | 1996 | 946 |
| 15 | Human primary liver cancer–derived organoid cultures for disease modeling and drug screening | Nature Medicine | 2017 | 905 |
| 16 | Contrast Medium-Induced Acute Kidney Injury | CardioRenal Medicine | 2015 | 791 |
| 17 | Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study | Lancet Oncology, The | 2019 | 773 |
| 18 | Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity | Nature | 2022 | 756 |
| 19 | ECCO Guidelines on Therapeutics in Crohn's Disease: Medical Treatment | Journal of Crohn's and Colitis | 2020 | 741 |
| 20 | Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene | Nature Genetics | 1998 | 720 |
| 21 | Consensus Guidelines on the Testing and Clinical Management Issues Associated With HLA and Non-HLA Antibodies in Transplantation | Transplantation | 2013 | 679 |
| 22 | Enhanced detection of circulating tumor DNA by fragment size analysis | Science Translational Medicine | 2018 | 670 |
| 23 | Emergence and global spread of epidemic healthcare-associated Clostridium difficile | Nature Genetics | 2013 | 669 |
| 24 | Tuberculous meningitis: a uniform case definition for use in clinical research | Lancet Infectious Diseases, The | 2010 | 659 |
| 25 | Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci | Nature Genetics | 2018 | 652 |
| 26 | Incidence of recurrent venous thromboembolism in relation to clinical and thrombophilic risk factors: prospective cohort study | Lancet, The | 2003 | 637 |
| 27 | Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study | Lancet, The | 2005 | 620 |
| 28 | Rapid Whole-Genome Sequencing for Investigation of a Neonatal MRSA Outbreak | New England Journal of Medicine | 2012 | 609 |
| 29 | VHL, the story of a tumour suppressor gene | Nature Reviews Cancer | 2015 | 572 |
| 30 | International consensus statement on the peri‐operative management of anaemia and iron deficiency | Anaesthesia | 2017 | 571 |
| 31 | Mycophenolate versus Azathioprine as Maintenance Therapy for Lupus Nephritis | New England Journal of Medicine | 2011 | 544 |
| 32 | Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines | World Journal of Emergency Surgery | 2020 | 533 |
| 33 | Whole-genome sequencing for analysis of an outbreak of meticillin-resistant Staphylococcus aureus: a descriptive study | Lancet Infectious Diseases, The | 2013 | 531 |
| 34 | Validation of dietary assessment methods in the UK arm of EPIC using weighed records, and 24-hour urinary nitrogen and potassium and serum vitamin C and carotenoids as biomarkers | International Journal of Epidemiology | 1997 | 523 |
| 35 | Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial | Lancet, The | 2021 | 519 |
| 36 | Docetaxel versus active symptom control for refractory oesophagogastric adenocarcinoma (COUGAR-02): an open-label, phase 3 randomised controlled trial | Lancet Oncology, The | 2014 | 516 |
| 37 | Clinical picture and treatment of 2212 patients with common variable immunodeficiency | Journal of Allergy and Clinical Immunology | 2014 | 512 |
| 38 | Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors | Science | 2018 | 511 |
| 39 | Global epidemiology of gastrointestinal stromal tumours (GIST): A systematic review of population-based cohort studies | Cancer Epidemiology | 2016 | 498 |
| 40 | A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium | Nature Genetics | 2009 | 481 |
| 41 | ECCO Guidelines on Therapeutics in Crohn’s Disease: Surgical Treatment | Journal of Crohn's and Colitis | 2020 | 478 |
| 42 | Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial | Lancet, The | 2017 | 469 |
| 43 | The landscape of somatic mutation in normal colorectal epithelial cells | Nature | 2019 | 468 |
| 44 | An integrated palliative and respiratory care service for patients with advanced disease and refractory breathlessness: a randomised controlled trial | Lancet Respiratory Medicine,the | 2014 | 464 |
| 45 | Germline mutations in RAD51D confer susceptibility to ovarian cancer | Nature Genetics | 2011 | 460 |
| 46 | Morbidity After Sentinel Lymph Node Biopsy in Primary Breast Cancer: Results From a Randomized Controlled Trial | Journal of Clinical Oncology | 2005 | 454 |
| 47 | 2012 provisional classification criteria for polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative | Annals of the Rheumatic Diseases | 2012 | 451 |
| 48 | Obesity Is Not Protective against Fracture in Postmenopausal Women: GLOW | American Journal of Medicine | 2011 | 446 |
| 49 | 2019 WSES guidelines for the management of severe acute pancreatitis | World Journal of Emergency Surgery | 2019 | 444 |
| 50 | Prenatal exome sequencing analysis in fetal structural anomalies detected by ultrasonography (PAGE): a cohort study | Lancet, The | 2019 | 443 |
