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Top Articles

#TitleJournalYearCitations
1Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populationsNature Genetics20151,965
2Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistanceNature Medicine2012753
3Solubilization and refolding of bacterial inclusion body proteinsJournal of Bioscience and Bioengineering2005629
4p53: traffic cop at the crossroads of DNA repair and recombinationNature Reviews Molecular Cell Biology2005478
5Biotechnological aspects of chitinolytic enzymes: a reviewApplied Microbiology and Biotechnology2006439
6Nanoclusters of GPI-Anchored Proteins Are Formed by Cortical Actin-Driven ActivityCell2008413
7Protein recovery from inclusion bodies of Escherichia coli using mild solubilization processMicrobial Cell Factories2015344
8Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparumNature Communications2011321
9Apolipoprotein E Polymorphism and Alzheimer DiseaseArchives of Neurology2000312
10Male germ cell apoptosis: regulation and biologyPhilosophical Transactions of the Royal Society B: Biological Sciences2010294
11Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteriaNature2004264
12NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthasesNucleic Acids Research2004262
13Interactions of antigen-loaded polylactide particles with macrophages and their correlation with the immune responseBiomaterials2007242
14Mycobacterium tuberculosis-Driven Targeted Recalibration of Macrophage Lipid Homeostasis Promotes the Foamy PhenotypeCell Host and Microbe2012237
15Hydrogen peroxide induces apoptosis-like death in Leishmania donovani promastigotesJournal of Cell Science2001211
16A vaccine that prevents pregnancy in women.Proceedings of the National Academy of Sciences of the United States of America1994205
17Optimization of Inclusion Body Solubilization and Renaturation of Recombinant Human Growth Hormone from Escherichia coliProtein Expression and Purification2000203
18Computational Approach for Prediction of Domain Organization and Substrate Specificity of Modular Polyketide SynthasesJournal of Molecular Biology2003202
19Vi polysaccharide of Salmonella typhi targets the prohibitin family of molecules in intestinal epithelial cells and suppresses early inflammatory responsesProceedings of the National Academy of Sciences of the United States of America2004197
20Modulation of immunogenicity and antigenicity of proteins by maleylation to target scavenger receptors on macrophages.Journal of Immunology1995184
21Maturation of an Antibody Response Is Governed by Modulations in Flexibility of the Antigen-Combining SiteImmunity2000183
22Increase in Cytosolic Ca2+ Levels through the Activation of Non-selective Cation Channels Induced by Oxidative Stress Causes Mitochondrial Depolarization Leading to Apoptosis-like Death in Leishmania donovaniPromastigotesJournal of Biological Chemistry2002183
23Three-dimensional chitosan scaffold-based MCF-7 cell culture for the determination of the cytotoxicity of tamoxifenBiomaterials2005181
24Hydrogen peroxide induces apoptosis-like death in Leishmania donovani promastigotesJournal of Cell Science2001177
25Role of RNA Interference (RNAi) in Dengue Virus Replication and Identification of NS4B as an RNAi SuppressorJournal of Virology2013175
26Prompt plasma exchanges and immunosuppressive treatment improves the outcomes of anti-factor H autoantibody-associated hemolytic uremic syndrome in childrenKidney International2014175
27Multifaceted pathways protect human skin from UV radiationNature Chemical Biology2014174
28Origin and radiation of the house mouse: mitochondrial DNA phylogenyJournal of Evolutionary Biology1996169
29Cell Signaling Pathways Involved During Invasion and Syncytialization of Trophoblast CellsAmerican Journal of Reproductive Immunology2016169
30Apoptotic Death in Leishmania donovani Promastigotes in Response to Respiratory Chain InhibitionJournal of Biological Chemistry2004167
31PGC-1α, a Key Modulator of p53, Promotes Cell Survival upon Metabolic StressMolecular Cell2011166
32SBSPKS: structure based sequence analysis of polyketide synthasesNucleic Acids Research2010162
33Beneficial effects of lamivudine in hepatitis B virus-related decompensated cirrhosisJournal of Hepatology2000152
34Transformation of mycobacterial species using hygromycin resistance as selectable markerMicrobiology (United Kingdom)1994147
35NF-κB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistanceBiochemical Journal2010147
36Antimonial-induced Increase in Intracellular Ca2+ through Non-selective Cation Channels in the Host and the Parasite Is Responsible for Apoptosis of Intracellular Leishmania donovani AmastigotesJournal of Biological Chemistry2003144
37Molecular Characterization of Multidrug-Resistant Isolates of Mycobacterium tuberculosis from Patients in North IndiaAntimicrobial Agents and Chemotherapy2002143
38Dissecting the Mechanism and Assembly of a Complex Virulence Mycobacterial LipidMolecular Cell2005143
39Rhodium(II) acetate-catalyzed stereoselective synthesis, SAR and anti-HIV activity of novel oxindoles bearing cyclopropane ringEuropean Journal of Medicinal Chemistry2011142
40Mycobacteria modulate host epigenetic machinery by Rv1988 methylation of a non-tail arginine of histone H3Nature Communications2015138
41PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin traffickingBlood2010129
42Live Salmonella Modulate Expression of Rab Proteins to Persist in a Specialized Compartment and Escape Transport to LysosomesJournal of Biological Chemistry2000128
43Expression of Cytokines in Placentas of Mice Undergoing Immunologically Mediated Spontaneous Fetal Resorptions1Biology of Reproduction1993126
44Improved immune response from biodegradable polymer particles entrapping tetanus toxoid by use of different immunization protocol and adjuvantsInternational Journal of Pharmaceutics2002124
45JAK/STAT3 Pathway Is Involved in Survival of Neurons in Response to Insulin-like Growth Factor and Negatively Regulated by Suppressor of Cytokine Signaling-3Journal of Biological Chemistry2005123
46Microbial community profiling shows dysbiosis in the lesional skin of Vitiligo subjectsScientific Reports2016122
47SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functionsProceedings of the National Academy of Sciences of the United States of America2016122
48Pleiotropic consequences of Bruton tyrosine kinase deficiency in myeloid lineages lead to poor inflammatory responsesBlood2004120
49Lessons from mathematically modeling the NF‐κB pathwayImmunological Reviews2012120
50Origin and radiation of the house mouse: clues from nuclear genesJournal of Evolutionary Biology1996119