| # | Title | Journal | Year | Citations |
|---|
| 1 | The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary | Acta Neuropathologica | 2016 | 12,144 |
| 2 | The 2007 WHO Classification of Tumours of the Central Nervous System | Acta Neuropathologica | 2007 | 9,898 |
| 3 | Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor | Cell | 1999 | 5,895 |
| 4 | Topological domains in mammalian genomes identified by analysis of chromatin interactions | Nature | 2012 | 5,786 |
| 5 | Cell Migration: Integrating Signals from Front to Back | Science | 2003 | 4,337 |
| 6 | Cancer immunoediting: from immunosurveillance to tumor escape | Nature Immunology | 2002 | 4,290 |
| 7 | Human DNA methylomes at base resolution show widespread epigenomic differences | Nature | 2009 | 4,063 |
| 8 | Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies | Science Translational Medicine | 2014 | 3,665 |
| 9 | TGF-β signalling from cell membrane to nucleus through SMAD proteins | Nature | 1997 | 3,514 |
| 10 | Full-length RNA-seq from single cells using Smart-seq2 | Nature Protocols | 2014 | 3,308 |
| 11 | N6-methyladenosine-dependent regulation of messenger RNA stability | Nature | 2014 | 3,138 |
| 12 | A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma | Science | 1991 | 3,128 |
| 13 | Live or let die: the cell's response to p53 | Nature Reviews Cancer | 2002 | 2,906 |
| 14 | Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome | Nature Genetics | 2007 | 2,898 |
| 15 | Patterns of somatic mutation in human cancer genomes | Nature | 2007 | 2,802 |
| 16 | The Immunobiology of Cancer Immunosurveillance and Immunoediting | Immunity | 2004 | 2,486 |
| 17 | The Three Es of Cancer Immunoediting | Annual Review of Immunology | 2004 | 2,422 |
| 18 | IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity | Nature | 2001 | 2,400 |
| 19 | DNA sequence and expression of the B95-8 Epstein—Barr virus genome | Nature | 1984 | 2,339 |
| 20 | Histone modifications at human enhancers reflect global cell-type-specific gene expression | Nature | 2009 | 2,225 |
| 21 | Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways | Science | 1997 | 2,209 |
| 22 | Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 | Cell Death and Differentiation | 2012 | 2,144 |
| 23 | Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor | Physiological Reviews | 1999 | 2,141 |
| 24 | Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 2,100 |
| 25 | Exosomes: Extracellular organelles important in intercellular communication | Journal of Proteomics | 2010 | 2,087 |
| 26 | Protection from obesity-induced insulin resistance in mice lacking TNF-α function | Nature | 1997 | 2,037 |
| 27 | Smart-seq2 for sensitive full-length transcriptome profiling in single cells | Nature Methods | 2013 | 2,022 |
| 28 | Dendritic Cells | Cell | 2001 | 2,009 |
| 29 | Malignant astrocytic glioma: genetics, biology, and paths to treatment | Genes and Development | 2007 | 1,952 |
| 30 | An improved Bonferroni procedure for multiple tests of significance | Biometrika | 1986 | 1,937 |
| 31 | Induction of c-fos-like protein in spinal cord neurons following sensory stimulation | Nature | 1987 | 1,912 |
| 32 | Phosphatidylinositol-3-OH kinase direct target of Ras | Nature | 1994 | 1,886 |
| 33 | Quadrivalent Vaccine against Human Papillomavirus to Prevent High-Grade Cervical Lesions | New England Journal of Medicine | 2007 | 1,886 |
| 34 | Antibody therapy of cancer | Nature Reviews Cancer | 2012 | 1,861 |
| 35 | Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma | New England Journal of Medicine | 2012 | 1,836 |
| 36 | Interleukin-6: An Overview | Annual Review of Immunology | 1990 | 1,832 |
| 37 | High interstitial fluid pressure — an obstacle in cancer therapy | Nature Reviews Cancer | 2004 | 1,814 |
| 38 | Molecular regulation of angiogenesis and lymphangiogenesis | Nature Reviews Molecular Cell Biology | 2007 | 1,711 |
| 39 | ROCKs: multifunctional kinases in cell behaviour | Nature Reviews Molecular Cell Biology | 2003 | 1,710 |
| 40 | Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling | Nature | 1997 | 1,684 |
| 41 | Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene | EMBO Journal | 1998 | 1,637 |
| 42 | Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair | Cell | 2008 | 1,627 |
| 43 | Dimerization of cell surface receptors in signal transduction | Cell | 1995 | 1,571 |
| 44 | Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis | Nature Medicine | 2001 | 1,555 |
| 45 | Decoding ALS: from genes to mechanism | Nature | 2016 | 1,533 |
| 46 | ChIP-seq accurately predicts tissue-specific activity of enhancers | Nature | 2009 | 1,526 |
| 47 | Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome | Nature Genetics | 2001 | 1,488 |
| 48 | Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions | Nature Medicine | 2001 | 1,484 |
| 49 | Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification | Cell | 2011 | 1,462 |
| 50 | Synthesis and Function of 3-Phosphorylated Inositol Lipids | Annual Review of Biochemistry | 2001 | 1,457 |
