| # | Title | Journal | Year | Citations |
|---|
| 1 | Mild cognitive impairment | Lancet, The | 2006 | 2,401 |
| 2 | Cardiogenic shock complicating acute myocardial infarction—etiologies, management and outcome: a report from the SHOCK Trial Registry | Journal of the American College of Cardiology | 2000 | 622 |
| 3 | Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy | Nature Genetics | 2002 | 584 |
| 4 | In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease | Annals of Neurology | 2000 | 515 |
| 5 | Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children | Canadian Journal of Cardiology | 2018 | 474 |
| 6 | Submaximal Exercise Testing: Clinical Application and Interpretation | Physical Therapy | 2000 | 435 |
| 7 | The 2015 Canadian Hypertension Education Program Recommendations for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension | Canadian Journal of Cardiology | 2015 | 431 |
| 8 | A multicenter, double-blind, randomized, placebo-controlled study of the efficacy and safety of botulinum toxin type A in the treatment of glabellar lines | Journal of the American Academy of Dermatology | 2002 | 413 |
| 9 | Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension | Canadian Journal of Cardiology | 2016 | 400 |
| 10 | Pulmonary embolism: prospective comparison of spiral CT with ventilation-perfusion scintigraphy. | Radiology | 1997 | 389 |
| 11 | Validity of the McGill Quality of Life Questionnaire in the palliative care setting: a multi-centre Canadian study demonstrating the importance of the existential domain | Palliative Medicine | 1997 | 358 |
| 12 | Reduction of Morbidity and Mortality by Statins, Angiotensin-Converting Enzyme Inhibitors, and Angiotensin Receptor Blockers in Patients With Chronic Obstructive Pulmonary Disease | Journal of the American College of Cardiology | 2006 | 357 |
| 13 | Traumatic Pneumothorax Detection with Thoracic US: Correlation with Chest Radiography and CT—Initial Experience | Radiology | 2002 | 345 |
| 14 | Association of mortality with age of blood transfused in septic ICU patients | Canadian Journal of Anaesthesia | 1997 | 343 |
| 15 | Idiopathic Interstitial Pneumonias: Diagnostic Accuracy of Thin-Section CT in 129 Patients | Radiology | 1999 | 336 |
| 16 | In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease | Annals of Neurology | 2000 | 329 |
| 17 | Hypertension Canada’s 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children | Canadian Journal of Cardiology | 2020 | 324 |
| 18 | Lack of Expression of Thy-1 (CD90) on Acute Myeloid Leukemia Cells With Long-Term Proliferative Ability In Vitro and In Vivo | Blood | 1997 | 317 |
| 19 | Factors Associated with Exercise Adherence Among Older Adults | Sports Medicine | 1999 | 316 |
| 20 | Interferon Gamma-1b Compared with Placebo in Metastatic Renal-Cell Carcinoma | New England Journal of Medicine | 1998 | 289 |
| 21 | Signaling through ?-catenin and Lef/Tcf | Cellular and Molecular Life Sciences | 1999 | 287 |
| 22 | Respiratory bronchiolitis, respiratory bronchiolitis-associated interstitial lung disease, and desquamative interstitial pneumonia: different entities or part of the spectrum of the same disease process? | American Journal of Roentgenology | 1999 | 286 |
| 23 | Perimenopause: The Complex Endocrinology of the Menopausal Transition | Endocrine Reviews | 1998 | 285 |
| 24 | Submaximal exercise in persons with stroke: test-retest reliability and concurrent validity with maximal oxygen consumption11No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated. | Archives of Physical Medicine and Rehabilitation | 2004 | 280 |
| 25 | Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults | Canadian Journal of Cardiology | 2017 | 269 |
| 26 | Locking Intramedullary Nailing with and without Reaming for Open Fractures of the Tibial Shaft. A Prospective, Randomized Study* | Journal of Bone and Joint Surgery - Series A | 1997 | 268 |
| 27 | Emphysema: definition, imaging, and quantification. | American Journal of Roentgenology | 1994 | 261 |
| 28 | Relationship of Balance and Mobility to Fall Incidence in People With Chronic Stroke | Physical Therapy | 2005 | 253 |
| 29 | Angiogenic gene therapy in patients with nonrevascularizable ischemic heart disease: a phase 2 randomized, controlled trial of AdVEGF121 (AdVEGF121) versus maximum medical treatment | Gene Therapy | 2006 | 244 |
| 30 | The Relationship of Lower-Extremity Muscle Torque to Locomotor Performance in People With Stroke | Physical Therapy | 2003 | 240 |
| 31 | Benzydamine HCl for prophylaxis of radiation-induced oral mucositis | Cancer | 2001 | 237 |
| 32 | Targeted gene deletion in Leishmania major identifies leishmanolysin (GP63) as a virulence factor | Molecular and Biochemical Parasitology | 2002 | 235 |
| 33 | Standardized evaluation of tumor-infiltrating lymphocytes in breast cancer: results of the ring studies of the international immuno-oncology biomarker working group | Modern Pathology | 2016 | 230 |
| 34 | Magnitude and pattern of 3D kinematic and kinetic gait profiles in persons with stroke: relationship to walking speed | Gait and Posture | 2004 | 228 |
| 35 | Ceramide Inhibits Protein Kinase B/Akt by Promoting Dephosphorylation of Serine 473 | Journal of Biological Chemistry | 2000 | 227 |
| 36 | Most Acute Myeloid Leukemia Progenitor Cells With Long-Term Proliferative Ability In Vitro and In Vivo Have the Phenotype CD34+/CD71−/HLA-DR− | Blood | 1998 | 221 |
| 37 | The 2014 Canadian Hypertension Education Program Recommendations for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension | Canadian Journal of Cardiology | 2014 | 221 |
| 38 | Follicular Bronchiolitis: Thin-Section CT and Histologic Findings | Radiology | 1999 | 212 |
| 39 | Factors Associated With Concussion-like Symptom Reporting in High School Athletes | JAMA Pediatrics | 2015 | 210 |
| 40 | Biochemical variations in the synaptic level of dopamine precede motor fluctuations in Parkinson's disease: PET evidence of increased dopamine turnover | Annals of Neurology | 2001 | 205 |
| 41 | Age-dependent decline of dopamine D1 receptors in human brain: A PET study | | 1998 | 203 |
| 42 | Interlocking Intramedullary Nailing with and without Reaming for the Treatment of Closed Fractures of the Tibial Shaft. A Prospective, Randomized Study* | Journal of Bone and Joint Surgery - Series A | 1997 | 198 |
| 43 | Airway wall thickness in patients with near fatal asthma and control groups: assessment with high resolution computed tomographic scanning | Thorax | 1998 | 197 |
| 44 | Embryonic ventral mesencephalic grafts improve levodopa-induced dyskinesia in a rat model of Parkinson's disease | Brain | 2000 | 190 |
| 45 | HER-2/neu in Breast Cancer: Interobserver Variability and Performance of Immunohistochemistry with 4 Antibodies Compared with Fluorescent In Situ Hybridization | Modern Pathology | 2001 | 187 |
| 46 | Hereditary form of parkinsonism—dementia | Annals of Neurology | 1998 | 183 |
| 47 | Retrieval and analysis of particulate debris after saphenous vein graft intervention | Journal of the American College of Cardiology | 1999 | 179 |
| 48 | Review of Pain-Measurement Tools☆☆☆★ | Annals of Emergency Medicine | 1996 | 176 |
| 49 | Hsp27 knockdown using nucleotide-based therapies inhibit tumor growth and enhance chemotherapy in human bladder cancer cells | Molecular Cancer Therapeutics | 2007 | 176 |
| 50 | Baseline stress myocardial perfusion imaging results and outcomes in patients with stable ischemic heart disease randomized to optimal medical therapy with or without percutaneous coronary intervention | American Heart Journal | 2012 | 175 |
