| # | Title | Journal | Year | Citations |
|---|
| 1 | Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis | Lancet Neurology, The | 2004 | 963 |
| 2 | Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway | Brain | 2011 | 942 |
| 3 | The EFSUMB Guidelines and Recommendations on the Clinical Practice of Contrast Enhanced Ultrasound (CEUS): Update 2011 on non-hepatic applications | Ultraschall in Der Medizin | 2012 | 922 |
| 4 | Glucagon-like peptide 1 (GLP-1) | Molecular Metabolism | 2019 | 850 |
| 5 | Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial | Lancet, The | 2018 | 528 |
| 6 | Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial | Lancet, The | 2011 | 485 |
| 7 | Predictors of Incretin Concentrations in Subjects With Normal, Impaired, and Diabetic Glucose Tolerance | Diabetes | 2008 | 307 |
| 8 | Autosomal dominant cerebellar ataxia: Phenotypic differences in genetically defined subtypes? | Annals of Neurology | 1997 | 298 |
| 9 | Palivizumab Prophylaxis, Respiratory Syncytial Virus, and Subsequent Recurrent Wheezing | Journal of Pediatrics | 2007 | 277 |
| 10 | Outcome and Cost-effectiveness of Perioperative Enteral Immunonutrition in Patients Undergoing Elective Upper Gastrointestinal Tract Surgery | Archives of Surgery | 1999 | 255 |
| 11 | Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humans | Diabetologia | 2006 | 244 |
| 12 | PIK3CA Mutations Are Associated With Lower Rates of Pathologic Complete Response to Anti–Human Epidermal Growth Factor Receptor 2 (HER2) Therapy in Primary HER2-Overexpressing Breast Cancer | Journal of Clinical Oncology | 2014 | 231 |
| 13 | Glucagon-Like Peptide 2 Stimulates Glucagon Secretion, Enhances Lipid Absorption, and Inhibits Gastric Acid Secretion in Humans | Gastroenterology | 2006 | 218 |
| 14 | Long-term disease progression in spinocerebellar ataxia types 1, 2, 3, and 6: a longitudinal cohort study | Lancet Neurology, The | 2015 | 213 |
| 15 | Long-term Therapy With Interleukin 6 Receptor Blockade in Highly Active Neuromyelitis Optica Spectrum Disorder | JAMA Neurology | 2015 | 206 |
| 16 | First Analysis of the Long-Term Results with Transrectal HIFU in Patients with Localised Prostate Cancer | European Urology | 2008 | 197 |
| 17 | Oral fumaric acid esters for the treatment of active multiple sclerosis: an open-label, baseline-controlled pilot study | European Journal of Neurology | 2006 | 195 |
| 18 | The effect of respiratory syncytial virus on subsequent recurrent wheezing in atopic and nonatopic children | Journal of Allergy and Clinical Immunology | 2010 | 195 |
| 19 | Elevated Plasma Levels of Homocysteine inParkinson’s Disease | European Neurology | 1998 | 175 |
| 20 | Impact of CYP2B6 983T>C polymorphism on non-nucleoside reverse transcriptase inhibitor plasma concentrations in HIV-infected patients | Journal of Antimicrobial Chemotherapy | 2008 | 169 |
| 21 | Spinocerebellar ataxia type 6: genotype and phenotype in German kindreds | Journal of Neurology, Neurosurgery and Psychiatry | 1998 | 167 |
| 22 | Mitochondrial impairment in patients and asymptomatic mutation carriers of Huntington's disease | Movement Disorders | 2005 | 162 |
| 23 | Spinocerebellar Ataxia Type 2 | Archives of Neurology | 1997 | 161 |
| 24 | Friedreich's ataxia. Revision of the phenotype according to molecular genetics | Brain | 1997 | 147 |
| 25 | Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells | Journal of Cellular Biochemistry | 2006 | 146 |
| 26 | Towards the implementation of ‘no evidence of disease activity’ in multiple sclerosis treatment: the multiple sclerosis decision model | Therapeutic Advances in Neurological Disorders | 2015 | 145 |
| 27 | Diagnosis, prevalence estimation and burden measurement in population surveys of headache: presenting the HARDSHIP questionnaire | Journal of Headache and Pain | 2014 | 136 |
| 28 | FOLFOXIRI Plus Panitumumab As First-Line Treatment of RAS Wild-Type Metastatic Colorectal Cancer: The Randomized, Open-Label, Phase II VOLFI Study (AIO KRK0109) | Journal of Clinical Oncology | 2019 | 132 |
| 29 | Exclusive Breastfeeding and the Effect on Postpartum Multiple Sclerosis Relapses | JAMA Neurology | 2015 | 126 |
| 30 | Efficacy and tolerability of tirzepatide, a dual glucose‐dependent insulinotropic peptide and glucagon‐like peptide‐1 receptor agonist in patients with type 2 diabetes: A 12‐week, randomized, double‐blind, placebo‐controlled study to evaluate different dose‐escalation regimens | Diabetes, Obesity and Metabolism | 2020 | 126 |
| 31 | Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans | Diabetologia | 2012 | 123 |
| 32 | Lumbar Disk Herniation: Correlation of Histologic Findings with Marrow Signal Intensity Changes in Vertebral Endplates at MR Imaging | Radiology | 2004 | 122 |
| 33 | Treatment of type 2 diabetes: challenges, hopes, and anticipated successes | Lancet Diabetes and Endocrinology,the | 2021 | 121 |
| 34 | Assessment of cardiac safety during fingolimod treatment initiation in a real-world relapsing multiple sclerosis population: a phase 3b, open-label study | Journal of Neurology | 2014 | 117 |
| 35 | p53-Dependent ICAM-1 overexpression in senescent human cells identified in atherosclerotic lesions | Laboratory Investigation | 2005 | 107 |
| 36 | β-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of β-Cell Dedifferentiation and Degranulation | Journal of Clinical Endocrinology and Metabolism | 2016 | 107 |
| 37 | A phase 1/2, dose-escalation trial of deferasirox for the treatment of iron overload in HFE-related hereditary hemochromatosis | Hepatology | 2010 | 103 |
| 38 | One-week low-dose triple therapy for Helicobacter pylori is sufficient for relief from symptoms and healing of duodenal ulcers | Alimentary Pharmacology and Therapeutics | 1997 | 100 |
| 39 | MR Venography in the Detection of Pelvic Venous Congestion | European Journal of Vascular and Endovascular Surgery | 2008 | 95 |
| 40 | Levodopa-Associated Increase of Homocysteine Levels and Sural Axonal Neurodegeneration | Archives of Neurology | 2004 | 94 |
| 41 | Diabetes and Aging: From Treatment Goals to Pharmacologic Therapy | Frontiers in Endocrinology | 2019 | 94 |
| 42 | Reduced Pancreatic Volume and β-Cell Area in Patients With Chronic Pancreatitis | Gastroenterology | 2009 | 93 |
| 43 | Selective increase of cerebrospinal fluid IL-6 during experimental systemic inflammation in humans: association with depressive symptoms | Molecular Psychiatry | 2017 | 93 |
| 44 | Present and Future Therapies in Neuromyelitis Optica Spectrum Disorders | Neurotherapeutics | 2016 | 90 |
| 45 | Evaluation of clinical, radiologic, and laboratory prebronchoscopy findings in children with suspected foreign body aspiration | Journal of Pediatric Surgery | 2006 | 88 |
| 46 | Operative results and outcome of twenty-four totally laparoscopic vascular procedures for aortoiliac occlusive disease | Journal of Vascular Surgery | 1998 | 85 |
| 47 | Intravenous thrombolysis prior to mechanical thrombectomy in large vessel occlusions | Annals of Neurology | 2019 | 84 |
| 48 | Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 1: Results from 163 lumbar punctures in 100 adult patients | Journal of Neuroinflammation | 2020 | 84 |
| 49 | Daclizumab high-yield process in relapsing-remitting multiple sclerosis (SELECTION): a multicentre, randomised, double-blind extension trial | Lancet Neurology, The | 2014 | 83 |
| 50 | Genotyping reveals a wide heterogeneity of Tropheryma whipplei | Microbiology (United Kingdom) | 2008 | 81 |
