| # | Title | Journal | Year | Citations |
|---|
| 1 | Oxidative Damage Is the Earliest Event in Alzheimer Disease | Journal of Neuropathology and Experimental Neurology | 2001 | 1,670 |
| 2 | Mitochondrial Abnormalities in Alzheimer's Disease | Journal of Neuroscience | 2001 | 1,179 |
| 3 | Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death | Journal of Cell Biology | 2004 | 775 |
| 4 | Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea | Nature Medicine | 2007 | 708 |
| 5 | Revised nomenclature and classification of inherited ichthyoses: Results of the First Ichthyosis Consensus Conference in Sorèze 2009 | Journal of the American Academy of Dermatology | 2010 | 610 |
| 6 | Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice | Nature Medicine | 2001 | 562 |
| 7 | Haploinsufficiency of NSD1 causes Sotos syndrome | Nature Genetics | 2002 | 560 |
| 8 | A sensitive method for detection of calmodulin-dependent protein kinase II activity in sodium dodecyl sulfate-polyacrylamide gel | Analytical Biochemistry | 1989 | 502 |
| 9 | Chronic health effects in people exposed to arsenic via the drinking water: dose?response relationships in review | Toxicology and Applied Pharmacology | 2004 | 492 |
| 10 | Involvement of Oxidative Stress in Alzheimer Disease | Journal of Neuropathology and Experimental Neurology | 2006 | 484 |
| 11 | RNA editing and death of motor neurons | Nature | 2004 | 479 |
| 12 | Body iron metabolism and pathophysiology of iron overload | International Journal of Hematology | 2008 | 465 |
| 13 | Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome | Nature Genetics | 2004 | 462 |
| 14 | Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis | Hepatology | 2004 | 426 |
| 15 | Integration of posture and locomotion in acute decerebrate cats and in awake, freely moving cats | Progress in Neurobiology | 1987 | 415 |
| 16 | Induction of interleukin-8 preserves the angiogenic response in HIF-1α–deficient colon cancer cells | Nature Medicine | 2005 | 394 |
| 17 | Development and Differences of Intestinal Flora in the Neonatal Period in Breast-Fed and Bottle-Fed Infants | Pediatrics | 1983 | 391 |
| 18 | A molecular phylogeny of the genus Echinococcus inferred from complete mitochondrial genomes | Parasitology | 2006 | 389 |
| 19 | Prevalence and distinctive biologic features of flat colorectal adenomas in a North American population | Gastroenterology | 2001 | 387 |
| 20 | New ribose-modified fluorescent analogs of adenine and guanine nucleotides available as subtrates for various enzymes | BBA - Proteins and Proteomics | 1983 | 382 |
| 21 | Plasma transforming growth factor-β1 level and efficacy of α-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study | Alimentary Pharmacology and Therapeutics | 2001 | 370 |
| 22 | Redox-Regulated Recruitment of the Transcriptional Coactivators CREB-Binding Protein and SRC-1 to Hypoxia-Inducible Factor 1α | Molecular and Cellular Biology | 2000 | 357 |
| 23 | Increased Iron and Free Radical Generation in Preclinical Alzheimer Disease and Mild Cognitive Impairment | Journal of Alzheimer's Disease | 2010 | 357 |
| 24 | Tissue-specific expression of four types of rat calmodulin-dependent protein kinase II mRNAs | Journal of Biological Chemistry | 1989 | 355 |
| 25 | Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma | British Journal of Cancer | 2008 | 348 |
| 26 | Basal ganglia efferents to the brainstem centers controlling postural muscle tone and locomotion: a new concept for understanding motor disorders in basal ganglia dysfunction | Neuroscience | 2003 | 341 |
| 27 | Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity | Nature Genetics | 2005 | 341 |
| 28 | Genetic and Phenotypic Analysis of Borrelia miyamotoi sp. nov., Isolated from the Ixodid Tick Ixodes persulcatus, the Vector for Lyme Disease in Japan | International Journal of Systematic Bacteriology | 1995 | 335 |
| 29 | Increased expression of PPARγ in high fat diet-induced liver steatosis in mice | Biochemical and Biophysical Research Communications | 2005 | 326 |
| 30 | Role of mitochondrial dysfunction in Alzheimer's disease | Journal of Neuroscience Research | 2002 | 324 |
| 31 | Current Issues in Measurement and Reporting of Urinary Albumin Excretion | Clinical Chemistry | 2009 | 298 |
| 32 | Microtubule Reduction in Alzheimer's Disease and Aging Is Independent of τ Filament Formation | American Journal of Pathology | 2003 | 294 |
| 33 | The Bcl-3 oncoprotein acts as a bridging factor between NF-κB/Rel and nuclear co-regulators | Oncogene | 1999 | 293 |
| 34 | Tissue-specific expression of four types of rat calmodulin-dependent protein kinase II mRNAs | Journal of Biological Chemistry | 1989 | 293 |
| 35 | Neprilysin Degrades Both Amyloid β Peptides 1–40 and 1–42 Most Rapidly and Efficiently among Thiorphan- and Phosphoramidon-sensitive Endopeptidases | Journal of Biological Chemistry | 2001 | 282 |
| 36 | In vitro endocrine disruption potential of organophosphate flame retardants via human nuclear receptors | Toxicology | 2013 | 276 |
| 37 | Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells | British Journal of Cancer | 2007 | 266 |
| 38 | A Novel Highly Specific and Potent Inhibitor of Calmodulin-Dependent Protein Kinase II | Biochemical and Biophysical Research Communications | 1995 | 264 |
| 39 | Ribosomal RNA in Alzheimer Disease Is Oxidized by Bound Redox-active Iron | Journal of Biological Chemistry | 2005 | 261 |
| 40 | Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy | Neurobiology of Disease | 2002 | 258 |
| 41 | Lumbar Degenerative Kyphosis | Spine | 1988 | 257 |
| 42 | Association between indoor exposure to semi-volatile organic compounds and building-related symptoms among the occupants of residential dwellings | Indoor Air | 2010 | 254 |
| 43 | Brain 14-3-3 protein is an activator protein that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca2+,calmodulin-dependent protein kinase II | FEBS Letters | 1987 | 253 |
| 44 | Role of basal ganglia–brainstem pathways in the control of motor behaviors | Neuroscience Research | 2004 | 250 |
| 45 | Correlations between Prenatal Exposure to Perfluorinated Chemicals and Reduced Fetal Growth | Environmental Health Perspectives | 2009 | 250 |
| 46 | Expression of glucocorticoid receptor β in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis | Gastroenterology | 2000 | 248 |
| 47 | Vascular endothelial growth factor rescues hippocampal neurons from glutamate‐induced toxicity: signal transduction cascades | FASEB Journal | 2001 | 246 |
| 48 | Azoospermia in patients heterozygous for a mutation in SYCP3 | Lancet, The | 2003 | 245 |
| 49 | Purification and Cahracyterization of te Brain Calmodulin-Dependent Protein Kinase (Kinase II), Which Is involved in the Activtion of Tryptophan 5-Monooxygnase | FEBS Journal | 1983 | 243 |
| 50 | Genetic characterization and phylogenetic position of Echinococcus felidis (Cestoda: Taeniidae) from the African lion | International Journal for Parasitology | 2008 | 242 |
