| # | Title | Journal | Year | Citations |
|---|
| 1 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 6,376 |
| 2 | Posthepatectomy liver failure: A definition and grading by the International Study Group of Liver Surgery (ISGLS) | Surgery | 2011 | 1,703 |
| 3 | Bile leakage after hepatobiliary and pancreatic surgery: A definition and grading of severity by the International Study Group of Liver Surgery | Surgery | 2011 | 1,596 |
| 4 | The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity | Nature | 2019 | 1,375 |
| 5 | ESMO Consensus Guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making | Annals of Oncology | 2012 | 1,233 |
| 6 | Incidence and Mortality of Acute Lung Injury and the Acute Respiratory Distress Syndrome in Three Australian States | American Journal of Respiratory and Critical Care Medicine | 2002 | 906 |
| 7 | Fatigue, alcohol and performance impairment | Nature | 1997 | 881 |
| 8 | Evolution of indications and results of liver transplantation in Europe. A report from the European Liver Transplant Registry (ELTR) | Journal of Hepatology | 2012 | 734 |
| 9 | Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017 | Annals of the Rheumatic Diseases | 2020 | 732 |
| 10 | Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment | Human Reproduction | 1998 | 703 |
| 11 | European Society of Cardiology: Cardiovascular Disease Statistics 2019 | European Heart Journal | 2020 | 690 |
| 12 | Systematic Review of Patients Presenting With Suspected Myocardial Infarction and Nonobstructive Coronary Arteries | Circulation | 2015 | 668 |
| 13 | Homeosis and intestinal tumours in Cdx2 mutant mice | Nature | 1997 | 618 |
| 14 | Continuous positive airways pressure for obstructive sleep apnoea in adults | Nature | 2006 | 552 |
| 15 | Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis | JAMA - Journal of the American Medical Association | 2019 | 548 |
| 16 | Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia | Nature Genetics | 2011 | 524 |
| 17 | The Presence and Severity of Chronic Kidney Disease Predicts All-Cause Mortality in Type 1 Diabetes | Diabetes | 2009 | 511 |
| 18 | Evolution of liver transplantation in Europe: Report of the European Liver Transplant Registry | Liver Transplantation | 2003 | 495 |
| 19 | Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II) | Biochemical Journal | 1993 | 475 |
| 20 | Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome | Nature Genetics | 2013 | 427 |
| 21 | Management of gastric cancer in Asia: resource-stratified guidelines | Lancet Oncology, The | 2013 | 418 |
| 22 | Looking Back to the Advent of Modern Endoscopy: 150th Birthday of Maximilian Nitze | World Journal of Surgery | 1998 | 416 |
| 23 | Oocyte–somatic cell interactions during follicle development in mammals | Animal Reproduction Science | 2004 | 415 |
| 24 | HER2 screening data from ToGA: targeting HER2 in gastric and gastroesophageal junction cancer | Gastric Cancer | 2015 | 415 |
| 25 | Diabetes and Cardiovascular Disease Outcomes in the Metabolically Healthy Obese Phenotype | Diabetes Care | 2013 | 402 |
| 26 | Effect of non-invasive positive pressure ventilation (NIPPV) on mortality in patients with acute cardiogenic pulmonary oedema: a meta-analysis | Lancet, The | 2006 | 399 |
| 27 | Preliminary observations on polar body extrusion and pronuclear formation in human oocytes using time-lapse video cinematography | Human Reproduction | 1997 | 397 |
| 28 | The role of zinc in caspase activation and apoptotic cell death | BioMetals | 2001 | 381 |
| 29 | A metaanalysis of treatment outcomes of early enteral versus early parenteral nutrition in hospitalized patients* | Critical Care Medicine | 2005 | 381 |
| 30 | A BLINDED, LONG-TERM, RANDOMIZED MULTICENTER STUDY OF MYCOPHENOLATE MOFETIL IN CADAVERIC RENAL TRANSPLANTATION | Transplantation | 1998 | 372 |
| 31 | Sirolimus Use in Liver Transplant Recipients With Hepatocellular Carcinoma | Transplantation | 2016 | 339 |
| 32 | Effects of in-vivo and in-vitro environments on the metabolism of the cumulus-oocyte complex and its influence on oocyte developmental capacity | Human Reproduction Update | 2003 | 333 |
| 33 | The Purification and Properties of Cyclohexanone Oxygenase from Nocardia globerula CL1 and Acinetobacter NCIB 9871 | FEBS Journal | 1976 | 328 |
| 34 | 2018 Annual Report of the European Liver Transplant Registry (ELTR) - 50-year evolution of liver transplantation | Transplant International | 2018 | 325 |
| 35 | Foxp3+ Regulatory T Cells, Th17 Effector Cells, and Cytokine Environment in Inflammatory Bowel Disease | Journal of Clinical Immunology | 2010 | 322 |
| 36 | A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, ProCESS and ProMISe Investigators | Intensive Care Medicine | 2015 | 321 |
| 37 | Improving reproductive performance in overweight/obese women with effective weight management | Human Reproduction Update | 2004 | 320 |
| 38 | Post-hepatectomy haemorrhage: a definition and grading by the International Study Group of Liver Surgery (ISGLS) | Hpb | 2011 | 312 |
| 39 | Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin | Diabetes Care | 2013 | 308 |
| 40 | Relative risk of conversion from normoglycaemia to impaired glucose tolerance or non-insulin dependent diabetes mellitus in polycystic ovarian syndrome | Human Reproduction | 2001 | 307 |
| 41 | Short-Term Outcomes of the Australasian Randomized Clinical Study Comparing Laparoscopic and Conventional Open Surgical Treatments for Colon Cancer | Annals of Surgery | 2008 | 306 |
| 42 | Oocyte-secreted factors enhance oocyte developmental competence | Developmental Biology | 2006 | 303 |
| 43 | The Association Between Dietary Sodium Intake, ESRD, and All-Cause Mortality in Patients With Type 1 Diabetes | Diabetes Care | 2011 | 301 |
| 44 | Role of copper in reducing hospital environment contamination | Journal of Hospital Infection | 2010 | 300 |
| 45 | Oocytes prevent cumulus cell apoptosis by maintaining a morphogenic paracrine gradient of bone morphogenetic proteins | Journal of Cell Science | 2005 | 296 |
| 46 | Tiotropium and olodaterol fixed-dose combinationversusmono-components in COPD (GOLD 2–4) | European Respiratory Journal | 2015 | 294 |
| 47 | Melatonin and sleep in humans | Journal of Pineal Research | 1993 | 293 |
| 48 | International consensus conference on stool banking for faecal microbiota transplantation in clinical practice | Gut | 2019 | 290 |
| 49 | Noninvasive ventilation in acute respiratory failure— A meta-analysis update | Critical Care Medicine | 2002 | 289 |
| 50 | An International Definition for “Nursing Home” | Journal of the American Medical Directors Association | 2015 | 286 |
