| # | Title | Journal | Year | Citations |
|---|
| 1 | Model-based Analysis of ChIP-Seq (MACS) | Genome Biology | 2008 | 13,517 |
| 2 | Role of Insulin Resistance in Human Disease | Diabetes | 1988 | 10,677 |
| 3 | Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray | Science | 1995 | 8,657 |
| 4 | Glutamate neurotoxicity and diseases of the nervous system | Neuron | 1988 | 6,912 |
| 5 | Adherence to Medication | New England Journal of Medicine | 2005 | 6,773 |
| 6 | Comprehensive Identification of Cell Cycle–regulated Genes of the YeastSaccharomyces cerevisiaeby Microarray Hybridization | Molecular Biology of the Cell | 1998 | 4,372 |
| 7 | The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes | Blood | 2009 | 3,864 |
| 8 | Identification of a major co-receptor for primary isolates of HIV-1 | Nature | 1996 | 3,667 |
| 9 | Exercise Capacity and Mortality among Men Referred for Exercise Testing | New England Journal of Medicine | 2002 | 3,286 |
| 10 | Epileptic Seizures and Epilepsy: Definitions Proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE) | Epilepsia | 2005 | 2,809 |
| 11 | Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity | Cell | 1991 | 2,735 |
| 12 | National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group Report | Biology of Blood and Marrow Transplantation | 2015 | 2,636 |
| 13 | Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma | Clinical Cancer Research | 2004 | 2,393 |
| 14 | Wnt signaling: a common theme in animal development | Genes and Development | 1997 | 2,276 |
| 15 | Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU | Critical Care Medicine | 2018 | 2,074 |
| 16 | Late-Onset Sepsis in Very Low Birth Weight Neonates: The Experience of the NICHD Neonatal Research Network | Pediatrics | 2002 | 2,061 |
| 17 | Resting-State Functional Connectivity in Major Depression: Abnormally Increased Contributions from Subgenual Cingulate Cortex and Thalamus | Biological Psychiatry | 2007 | 1,979 |
| 18 | Use of a cDNA microarray to analyse gene expression patterns in human cancer | Nature Genetics | 1996 | 1,868 |
| 19 | Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse | Neuron | 2016 | 1,741 |
| 20 | Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells | Nature Medicine | 1996 | 1,731 |
| 21 | Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage | Trends in Neurosciences | 1988 | 1,647 |
| 22 | Stem Cells | Cell | 2000 | 1,623 |
| 23 | PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity | Nature | 2017 | 1,489 |
| 24 | Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer | Cell | 2015 | 1,485 |
| 25 | Ketamine—Its Pharmacology and Therapeutic Uses | Anesthesiology | 1982 | 1,473 |
| 26 | ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee | Journal of the American College of Radiology | 2017 | 1,473 |
| 27 | Parallel human genome analysis: microarray-based expression monitoring of 1000 genes. | Proceedings of the National Academy of Sciences of the United States of America | 1996 | 1,464 |
| 28 | International scoring system for evaluating prognosis in myelodysplastic syndromes | Blood | 1997 | 1,411 |
| 29 | Random Systematic Versus Directed Ultrasound Guided Transrectal Core Biopsies of the Prostate | Journal of Urology | 1989 | 1,408 |
| 30 | How Do Risk Factors Work Together? Mediators, Moderators, and Independent, Overlapping, and Proxy Risk Factors | American Journal of Psychiatry | 2001 | 1,401 |
| 31 | International Consensus on Use of Continuous Glucose Monitoring | Diabetes Care | 2017 | 1,376 |
| 32 | Physician burnout: contributors, consequences and solutions | Journal of Internal Medicine | 2018 | 1,369 |
| 33 | The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 1,315 |
| 34 | The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 1,255 |
| 35 | Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC) | Blood | 2007 | 1,243 |
| 36 | Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones | Science | 1992 | 1,214 |
| 37 | Prospective Surveillance for Invasive Fungal Infections in Hematopoietic Stem Cell Transplant Recipients, 2001–2006: Overview of the Transplant‐Associated Infection Surveillance Network (TRANSNET) Database | Clinical Infectious Diseases | 2010 | 1,194 |
| 38 | Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy | Lancet, The | 1993 | 1,189 |
| 39 | Doxorubicin pathways | Pharmacogenetics and Genomics | 2011 | 1,167 |
| 40 | Abatacept for Rheumatoid Arthritis Refractory to Tumor Necrosis Factor α Inhibition | New England Journal of Medicine | 2005 | 1,157 |
| 41 | Magnetic resonance imaging profiles predict clinical response to early reperfusion: The diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study | Annals of Neurology | 2006 | 1,138 |
| 42 | Angiographic Versus Functional Severity of Coronary Artery Stenoses in the FAME Study | Journal of the American College of Cardiology | 2010 | 1,077 |
| 43 | The Effect of Adjuvant Chemotherapy on Relapse-Free Survival in Patients with Osteosarcoma of the Extremity | New England Journal of Medicine | 1986 | 1,071 |
| 44 | Zonal Distribution of Prostatic Adenocarcinoma | American Journal of Surgical Pathology | 1988 | 1,060 |
| 45 | Impact of Cancer‐Related Fatigue on the Lives of Patients: New Findings From the Fatigue Coalition | Oncologist | 2000 | 1,048 |
| 46 | Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF | Nature | 2001 | 1,030 |
| 47 | Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke (TREVO 2): a randomised trial | Lancet, The | 2012 | 1,030 |
| 48 | How Hofmeister ion interactions affect protein stability | Biophysical Journal | 1996 | 1,029 |
| 49 | Bruton Tyrosine Kinase Inhibitor Ibrutinib (PCI-32765) Has Significant Activity in Patients With Relapsed/Refractory B-Cell Malignancies | Journal of Clinical Oncology | 2013 | 991 |
| 50 | Fractional Flow Reserve Versus Angiography for Guiding Percutaneous Coronary Intervention in Patients With Multivessel Coronary Artery Disease | Journal of the American College of Cardiology | 2010 | 990 |
