# | Title | Journal | Year | Citations |
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1 | Prospective identification of tumorigenic breast cancer cells | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 9,314 |
2 | Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease | American Journal of Respiratory and Critical Care Medicine | 2013 | 7,792 |
3 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
4 | Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer | Thyroid | 2009 | 6,039 |
5 | Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial | Lancet, The | 1998 | 5,398 |
6 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
7 | A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease | Nature | 2001 | 4,589 |
8 | Insulin signalling and the regulation of glucose and lipid metabolism | Nature | 2001 | 4,324 |
9 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
10 | Tissue Destruction by Neutrophils | New England Journal of Medicine | 1989 | 3,891 |
11 | In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro | Nature Protocols | 2007 | 3,638 |
12 | Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer | Science | 2005 | 3,541 |
13 | A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C | Hepatology | 2003 | 3,455 |
14 | Understanding the tumor immune microenvironment (TIME) for effective therapy | Nature Medicine | 2018 | 3,421 |
15 | Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial | Lancet, The | 2017 | 3,224 |
16 | ONCOMINE: A Cancer Microarray Database and Integrated Data-Mining Platform | Neoplasia | 2004 | 3,212 |
17 | Rapamycin fed late in life extends lifespan in genetically heterogeneous mice | Nature | 2009 | 3,191 |
18 | NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals | Nature | 2010 | 3,130 |
19 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
20 | Identification of Pancreatic Cancer Stem Cells | Cancer Research | 2007 | 3,017 |
21 | bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death | Cell | 1993 | 2,976 |
22 | The American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia and Measurement of Symptom Severity | Arthritis Care and Research | 2010 | 2,964 |
23 | FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex | Cell | 1996 | 2,944 |
24 | A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes | Cancer Cell | 2006 | 2,729 |
25 | Second consensus statement on the diagnosis of multiple system atrophy | Neurology | 2008 | 2,720 |
26 | Crystal structure of the β2 adrenergic receptor–Gs protein complex | Nature | 2011 | 2,712 |
27 | THE MAMMALIAN UNFOLDED PROTEIN RESPONSE | Annual Review of Biochemistry | 2005 | 2,699 |
28 | TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling | Nature Cell Biology | 2002 | 2,667 |
29 | Integrative Clinical Genomics of Advanced Prostate Cancer | Cell | 2015 | 2,660 |
30 | Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009 | Cell Death and Differentiation | 2009 | 2,572 |
31 | Chronic hepatitis B: Update 2009 | Hepatology | 2009 | 2,506 |
32 | Chronic hepatitis B | Hepatology | 2007 | 2,422 |
33 | A reference panel of 64,976 haplotypes for genotype imputation | Nature Genetics | 2016 | 2,421 |
34 | The polycomb group protein EZH2 is involved in progression of prostate cancer | Nature | 2002 | 2,411 |
35 | Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase | Cell | 1995 | 2,396 |
36 | FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis | Cell | 1995 | 2,298 |
37 | Cyclooxygenase in biology and disease | FASEB Journal | 1998 | 2,208 |
38 | Recommendations for Conduct, Methodological Practices, and Reporting of Cost-effectiveness Analyses | JAMA - Journal of the American Medical Association | 2016 | 2,149 |
39 | Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 | Cell Death and Differentiation | 2012 | 2,144 |
40 | The mutational landscape of lethal castration-resistant prostate cancer | Nature | 2012 | 2,128 |
41 | Oncogenic Signaling Pathways in The Cancer Genome Atlas | Cell | 2018 | 2,111 |
42 | Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt | Science | 1997 | 2,085 |
43 | Implementing an Antibiotic Stewardship Program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America | Clinical Infectious Diseases | 2016 | 2,060 |
44 | Mechanism and Regulation of NLRP3 Inflammasome Activation | Trends in Biochemical Sciences | 2016 | 1,993 |
45 | A methodology for performing global uncertainty and sensitivity analysis in systems biology | Journal of Theoretical Biology | 2008 | 1,985 |
46 | A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases | Nature Medicine | 2015 | 1,967 |
47 | Extracellular DNA traps promote thrombosis | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 1,940 |
48 | Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment | Cell Host and Microbe | 2013 | 1,913 |
49 | Bowel Disorders | Gastroenterology | 2016 | 1,912 |
50 | A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility | Cell | 2016 | 1,882 |