| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 3 | Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors | Science | 2018 | 3,689 |
| 4 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update | Annals of the Rheumatic Diseases | 2017 | 3,366 |
| 5 | Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet, The | 2017 | 2,771 |
| 6 | Structure and function of the global ocean microbiome | Science | 2015 | 2,137 |
| 7 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 8 | A random forest guided tour | Test | 2016 | 1,703 |
| 9 | Efficient storage mechanisms for building better supercapacitors | Nature Energy | 2016 | 1,655 |
| 10 | Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors | JAMA Oncology | 2018 | 1,625 |
| 11 | Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma | JAMA - Journal of the American Medical Association | 2017 | 1,619 |
| 12 | Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity | Cell | 2014 | 1,515 |
| 13 | Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria | Movement Disorders | 2017 | 1,402 |
| 14 | Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria | Alzheimer's and Dementia | 2016 | 1,318 |
| 15 | Polyvinylpyrrolidone (PVP) in nanoparticle synthesis | Dalton Transactions | 2015 | 1,176 |
| 16 | Seven temperate terrestrial planets around the nearby ultracool dwarf star TRAPPIST-1 | Nature | 2017 | 1,144 |
| 17 | Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2017 | 1,126 |
| 18 | CRISPOR: intuitive guide selection for CRISPR/Cas9 genome editing experiments and screens | Nucleic Acids Research | 2018 | 1,114 |
| 19 | Accurately extracting the signature of intermolecular interactions present in the NCI plot of the reduced density gradient versus electron density | Physical Chemistry Chemical Physics | 2017 | 1,068 |
| 20 | Drop Impact on a Solid Surface | Annual Review of Fluid Mechanics | 2016 | 1,021 |
| 21 | Biology of Zika Virus Infection in Human Skin Cells | Journal of Virology | 2015 | 1,015 |
| 22 | Development and Validation of the HScore, a Score for the Diagnosis of Reactive Hemophagocytic Syndrome | Arthritis and Rheumatology | 2014 | 875 |
| 23 | Where less may be more: how the rare biosphere pulls ecosystems strings | ISME Journal | 2017 | 857 |
| 24 | Determinants of community structure in the global plankton interactome | Science | 2015 | 842 |
| 25 | Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer | Nature Reviews Cancer | 2015 | 839 |
| 26 | Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT) | Lancet, The | 2016 | 790 |
| 27 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 28 | Complement System Part II: Role in Immunity | Frontiers in Immunology | 2015 | 762 |
| 29 | DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis | American Journal of Human Genetics | 2016 | 717 |
| 30 | Use of prostate systematic and targeted biopsy on the basis of multiparametric MRI in biopsy-naive patients (MRI-FIRST): a prospective, multicentre, paired diagnostic study | Lancet Oncology, The | 2019 | 701 |
| 31 | Help from the Sky: Leveraging UAVs for Disaster Management | IEEE Pervasive Computing | 2017 | 689 |
| 32 | Plankton networks driving carbon export in the oligotrophic ocean | Nature | 2016 | 670 |
| 33 | Robots that can adapt like animals | Nature | 2015 | 646 |
| 34 | Gaia Data Release 2 | Astronomy and Astrophysics | 2018 | 638 |
| 35 | Increased reporting of fatal immune checkpoint inhibitor-associated myocarditis | Lancet, The | 2018 | 618 |
| 36 | Dancing in the dark: galactic properties trace spin swings along the cosmic web | Monthly Notices of the Royal Astronomical Society | 2014 | 614 |
| 37 | Hippocampal GABAergic Inhibitory Interneurons | Physiological Reviews | 2017 | 601 |
| 38 | A kilonova as the electromagnetic counterpart to a gravitational-wave source | Nature | 2017 | 601 |
| 39 | Towards a standardization of biomethane potential tests | Water Science and Technology | 2016 | 592 |
| 40 | Safety focused modeling of lithium-ion batteries: A review | Journal of Power Sources | 2016 | 591 |
| 41 | Identification of an anti-inflammatory protein fromFaecalibacterium prausnitzii, a commensal bacterium deficient in Crohn’s disease | Gut | 2016 | 585 |
| 42 | Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism | Cancer Discovery | 2017 | 582 |
| 43 | Energy Transfer with Semiconductor Quantum Dot Bioconjugates: A Versatile Platform for Biosensing, Energy Harvesting, and Other Developing Applications | Chemical Reviews | 2017 | 575 |
| 44 | Petawatt and exawatt class lasers worldwide | High Power Laser Science and Engineering | 2019 | 574 |
| 45 | A rapid-screening approach to detect and quantify microplastics based on fluorescent tagging with Nile Red | Scientific Reports | 2017 | 540 |
| 46 | Current applications and new opportunities for the use of pulsed electric fields in food science and industry | Food Research International | 2015 | 538 |
| 47 | GaiaData Release 1 | Astronomy and Astrophysics | 2016 | 536 |
| 48 | Gland segmentation in colon histology images: The glas challenge contest | Medical Image Analysis | 2017 | 516 |
| 49 | Topological defects in epithelia govern cell death and extrusion | Nature | 2017 | 511 |
| 50 | Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis | Nature Genetics | 2016 | 494 |
