| # | Title | Journal | Year | Citations |
|---|
| 1 | The Hallmarks of Cancer | Cell | 2000 | 24,832 |
| 2 | Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease | Biochemistry | 1979 | 23,186 |
| 3 | Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome | New England Journal of Medicine | 2000 | 14,454 |
| 4 | The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary | Acta Neuropathologica | 2016 | 12,144 |
| 5 | A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules | Journal of the American Chemical Society | 1995 | 12,116 |
| 6 | Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 | Nature Biotechnology | 2019 | 11,167 |
| 7 | Design and validation of a histological scoring system for nonalcoholic fatty liver disease | Hepatology | 2005 | 8,518 |
| 8 | Grounded theory research: Procedures, canons, and evaluative criteria | Qualitative Sociology | 1990 | 6,446 |
| 9 | Molecular mechanisms of epithelial–mesenchymal transition | Nature Reviews Molecular Cell Biology | 2014 | 6,331 |
| 10 | Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis | Annals of Neurology | 2001 | 6,122 |
| 11 | NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease | Alzheimer's and Dementia | 2018 | 5,861 |
| 12 | THE weighted histogram analysis method for free-energy calculations on biomolecules. I. The method | Journal of Computational Chemistry | 1992 | 5,736 |
| 13 | Integrative analysis of 111 reference human epigenomes | Nature | 2015 | 5,653 |
| 14 | Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease | Alzheimer's and Dementia | 2011 | 5,550 |
| 15 | Signal integration in the endoplasmic reticulum unfolded protein response | Nature Reviews Molecular Cell Biology | 2007 | 5,491 |
| 16 | Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer | New England Journal of Medicine | 2010 | 5,481 |
| 17 | Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis | Science | 2006 | 5,422 |
| 18 | New functions for the matrix metalloproteinases in cancer progression | Nature Reviews Cancer | 2002 | 5,365 |
| 19 | Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure | New England Journal of Medicine | 2004 | 5,193 |
| 20 | Neurotoxic reactive astrocytes are induced by activated microglia | Nature | 2017 | 4,977 |
| 21 | Smad-dependent and Smad-independent pathways in TGF-β family signalling | Nature | 2003 | 4,773 |
| 22 | Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer | New England Journal of Medicine | 2010 | 4,724 |
| 23 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 24 | Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. | Proceedings of the National Academy of Sciences of the United States of America | 1988 | 4,652 |
| 25 | Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria | Lancet Neurology, The | 2018 | 4,605 |
| 26 | The 2021 WHO Classification of Tumors of the Central Nervous System: a summary | Neuro-Oncology | 2021 | 4,534 |
| 27 | UCSF ChimeraX: Structure visualization for researchers, educators, and developers | Protein Science | 2021 | 4,478 |
| 28 | SPIRIT 2013 Statement: Defining Standard Protocol Items for Clinical Trials | Annals of Internal Medicine | 2013 | 4,463 |
| 29 | Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men | New England Journal of Medicine | 2010 | 4,268 |
| 30 | Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS | Neuron | 2011 | 4,176 |
| 31 | A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations | Journal of Computational Chemistry | 2003 | 4,028 |
| 32 | Development of a Classification System for Periodontal Diseases and Conditions | Journal of Computational Chemistry | 1999 | 3,954 |
| 33 | Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia | Brain | 2011 | 3,913 |
| 34 | Calculated Absorption and Scattering Properties of Gold Nanoparticles of Different Size, Shape, and Composition: Applications in Biological Imaging and Biomedicine | Journal of Physical Chemistry B | 2006 | 3,896 |
| 35 | Classification of primary progressive aphasia and its variants | Neurology | 2011 | 3,885 |
| 36 | Global analysis of protein localization in budding yeast | Nature | 2003 | 3,884 |
| 37 | Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria | Cell | 2009 | 3,818 |
| 38 | How well does a restrained electrostatic potential (RESP) model perform in calculating conformational energies of organic and biological molecules? | Journal of Computational Chemistry | 2000 | 3,725 |
| 39 | A SARS-CoV-2 protein interaction map reveals targets for drug repurposing | Nature | 2020 | 3,542 |
| 40 | Macrophage biology in development, homeostasis and disease | Nature | 2013 | 3,541 |
| 41 | Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures | Lancet, The | 1996 | 3,496 |
| 42 | Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement | Endocrine Reviews | 2009 | 3,491 |
| 43 | Global analysis of protein expression in yeast | Nature | 2003 | 3,407 |
| 44 | UCSF ChimeraX: Meeting modern challenges in visualization and analysis | Protein Science | 2018 | 3,377 |
| 45 | ZINC − A Free Database of Commercially Available Compounds for Virtual Screening | Journal of Chemical Information and Modeling | 2005 | 3,366 |
| 46 | TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells | Nature | 2018 | 3,359 |
| 47 | Risk Factors for Hip Fracture in White Women | New England Journal of Medicine | 1995 | 3,296 |
| 48 | Gait Speed and Survival in Older Adults | JAMA - Journal of the American Medical Association | 2011 | 3,254 |
| 49 | An Official American Thoracic Society/European Respiratory Society Statement: Update of the International Multidisciplinary Classification of the Idiopathic Interstitial Pneumonias | American Journal of Respiratory and Critical Care Medicine | 2013 | 3,134 |
| 50 | The extracellular matrix at a glance | Journal of Cell Science | 2010 | 3,130 |
