| # | Title | Journal | Year | Citations |
|---|
| 1 | Multifactorial Intervention and Cardiovascular Disease in Patients with Type 2 Diabetes | New England Journal of Medicine | 2003 | 3,894 |
| 2 | Interleukin-1–Receptor Antagonist in Type 2 Diabetes Mellitus | New England Journal of Medicine | 2007 | 1,579 |
| 3 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6) | Lancet, The | 2009 | 1,324 |
| 4 | Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007–2017 | Cardiovascular Diabetology | 2018 | 1,198 |
| 5 | Hypothalamic CART is a new anorectic peptide regulated by leptin | Nature | 1998 | 1,147 |
| 6 | The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems—A review | International Journal of Pharmaceutics | 2011 | 1,002 |
| 7 | Efficacy and Safety Comparison of Liraglutide, Glimepiride, and Placebo, All in Combination With Metformin, in Type 2 Diabetes | Diabetes Care | 2009 | 991 |
| 8 | Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial | Lancet, The | 2009 | 935 |
| 9 | Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study | Lancet, The | 2009 | 931 |
| 10 | Analysis of Multivariate Survival Data | Statistics in the Health Sciences | 2000 | 922 |
| 11 | New Unstable Variants of Green Fluorescent Protein for Studies of Transient Gene Expression in Bacteria | Applied and Environmental Microbiology | 1998 | 883 |
| 12 | Glucagon-like peptide 1 (GLP-1) | Molecular Metabolism | 2019 | 850 |
| 13 | The sequence, crystal structure determination and refinement of two crystal forms of lipase B from Candida antarctica | Structure | 1994 | 817 |
| 14 | FDA-approved small-molecule kinase inhibitors | Trends in Pharmacological Sciences | 2015 | 794 |
| 15 | Efficacy and Safety of the Human Glucagon-Like Peptide-1 Analog Liraglutide in Combination With Metformin and Thiazolidinedione in Patients With Type 2 Diabetes (LEAD-4 Met+TZD) | Diabetes Care | 2009 | 768 |
| 16 | Anemia, Blood Loss, and Blood Transfusions in North American Children in the Intensive Care Unit | American Journal of Respiratory and Critical Care Medicine | 2008 | 760 |
| 17 | Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial | Diabetologia | 2009 | 747 |
| 18 | A general enhancement scheme in heteronuclear multidimensional NMR employing pulsed field gradients | Journal of Biomolecular NMR | 1994 | 728 |
| 19 | Psychosocial problems and barriers to improved diabetes management: results of the Cross-National Diabetes Attitudes, Wishes and Needs (DAWN) Study | Diabetic Medicine | 2005 | 728 |
| 20 | Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use | Diabetes | 2000 | 717 |
| 21 | Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells | Nature Medicine | 2011 | 714 |
| 22 | Resistance to Insulin Therapy Among Patients and Providers: Results of the cross-national Diabetes Attitudes, Wishes, and Needs (DAWN) study | Diabetes Care | 2005 | 709 |
| 23 | Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes | JAMA - Journal of the American Medical Association | 2015 | 707 |
| 24 | Consensus Guidelines for the Diagnosis and Treatment of Growth Hormone (GH) Deficiency in Childhood and Adolescence: Summary Statement of the GH Research Society | Journal of Clinical Endocrinology and Metabolism | 2000 | 703 |
| 25 | Guidelines for the validation and application of typing methods for use in bacterial epidemiology | Clinical Microbiology and Infection | 2007 | 668 |
| 26 | Structural and Evolutionary Relationships among Protein Tyrosine Phosphatase Domains | Molecular and Cellular Biology | 2001 | 660 |
| 27 | SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations | Nature Genetics | 2008 | 641 |
| 28 | BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression | Oncogene | 1998 | 636 |
| 29 | Qualitative research and content validity: developing best practices based on science and experience | Quality of Life Research | 2009 | 617 |
| 30 | One Biocatalyst–Many Applications: The Use of Candida Antarctica B-Lipase in Organic Synthesis | Biocatalysis and Biotransformation | 1998 | 615 |
| 31 | Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide | Journal of Medicinal Chemistry | 2015 | 609 |
| 32 | A 26-Week, Randomized, Parallel, Treat-to-Target Trial Comparing Insulin Detemir With NPH Insulin as Add-On Therapy to Oral Glucose-Lowering Drugs in Insulin-Naive People With Type 2 Diabetes | Diabetes Care | 2006 | 605 |
| 33 | PRODRG, a program for generating molecular topologies and unique molecular descriptors from coordinates of small molecules | Journal of Computer-Aided Molecular Design | 1996 | 596 |
| 34 | Potent Derivatives of Glucagon-like Peptide-1 with Pharmacokinetic Properties Suitable for Once Daily Administration | Journal of Medicinal Chemistry | 2000 | 591 |
| 35 | Lower Within-Subject Variability of Insulin Detemir in Comparison to NPH Insulin and Insulin Glargine in People With Type 1 Diabetes | Diabetes | 2004 | 570 |
| 36 | Adipose Triglyceride Lipase and Hormone-sensitive Lipase Are the Major Enzymes in Adipose Tissue Triacylglycerol Catabolism | Journal of Biological Chemistry | 2006 | 562 |
| 37 | Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus | Nature | 2005 | 557 |
| 38 | Initiating Insulin Therapy in Type 2 Diabetes: A comparison of biphasic and basal insulin analogs | Diabetes Care | 2005 | 547 |
| 39 | Diabetes Attitudes, Wishes and Needs second study (DAWN2™): Cross‐national benchmarking of diabetes‐related psychosocial outcomes for people with diabetes | Diabetic Medicine | 2013 | 540 |
| 40 | Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial | Lancet, The | 2010 | 534 |
| 41 | Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide | International Journal of Obesity | 2012 | 532 |
| 42 | Co-Localization of Growth Hormone Secretagogue Receptor and NPY mRNA in the Arcuate Nucleus of the Rat | Neuroendocrinology | 1999 | 529 |
| 43 | The Influence of GLP-1 on Glucose-Stimulated Insulin Secretion: Effects on -Cell Sensitivity in Type 2 and Nondiabetic Subjects | Diabetes | 2003 | 513 |
| 44 | Clinical Inertia in People With Type 2 Diabetes | Diabetes Care | 2013 | 508 |
| 45 | Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype | Journal of Biological Chemistry | 2010 | 505 |
| 46 | 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial | Lancet, The | 2017 | 502 |
| 47 | Enzyme immunoassay for intact human insulin in serum or plasma | Clinical Chemistry | 1993 | 485 |
| 48 | The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men | Diabetologia | 2002 | 476 |
| 49 | Glucagon-Like Peptide-1 Receptor Agonists Activate Rodent Thyroid C-Cells Causing Calcitonin Release and C-Cell Proliferation | Endocrinology | 2010 | 468 |
| 50 | Toward Understanding Insulin Fibrillation | Journal of Pharmaceutical Sciences | 1997 | 460 |
