| # | Title | Journal | Year | Citations |
|---|
| 1 | Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS | Neuron | 2011 | 4,176 |
| 2 | Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice | Science | 1996 | 4,040 |
| 3 | Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 | Nature | 1998 | 3,333 |
| 4 | Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease | Nature Medicine | 1996 | 2,545 |
| 5 | Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function | Science | 2005 | 1,766 |
| 6 | Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1 | Nature | 1996 | 1,480 |
| 7 | Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo | Neuron | 1996 | 1,471 |
| 8 | Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation | Annals of Thoracic Surgery | 1996 | 1,419 |
| 9 | Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP | Science | 2001 | 1,409 |
| 10 | A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity | Nature | 2001 | 1,352 |
| 11 | Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein | Nature Genetics | 2000 | 1,254 |
| 12 | The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease | Nature Genetics | 2007 | 1,045 |
| 13 | The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation | Nature Neuroscience | 2001 | 1,042 |
| 14 | Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS | Neuron | 2013 | 962 |
| 15 | Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease | Journal of Neuroscience | 2001 | 961 |
| 16 | Tauopathy in Drosophila : Neurodegeneration Without Neurofibrillary Tangles | Science | 2001 | 868 |
| 17 | Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice | Nature Neuroscience | 1999 | 855 |
| 18 | γ-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase | Science | 2001 | 825 |
| 19 | American College of Radiology White Paper on Radiation Dose in Medicine | Journal of the American College of Radiology | 2007 | 824 |
| 20 | Pharmacological profile of antidepressants and related compounds at human monoamine transporters | European Journal of Pharmacology | 1997 | 780 |
| 21 | Association of an Extended Haplotype in the Tau Gene with Progressive Supranuclear Palsy | Human Molecular Genetics | 1999 | 749 |
| 22 | The secretases: enzymes with therapeutic potential in Alzheimer disease | Nature Reviews Neurology | 2010 | 702 |
| 23 | GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport | Nature | 2015 | 692 |
| 24 | Epidemiology and natural history of atrial fibrillation: clinical implications | Journal of the American College of Cardiology | 2001 | 685 |
| 25 | The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease | Journal of Neuroscience | 2002 | 671 |
| 26 | Comparison of kindreds with parkinsonism and α‐synuclein genomic multiplications | Annals of Neurology | 2004 | 664 |
| 27 | Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial | Lancet Neurology, The | 2007 | 610 |
| 28 | Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease | Nature Medicine | 2019 | 610 |
| 29 | Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy | Movement Disorders | 2001 | 587 |
| 30 | Parkin Protects against the Toxicity Associated with Mutant α-Synuclein | Neuron | 2002 | 542 |
| 31 | Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data | BMJ, The | 2014 | 528 |
| 32 | Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 523 |
| 33 | Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins | Neuron | 1995 | 520 |
| 34 | Two‐year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial | Epilepsia | 2014 | 520 |
| 35 | Genome-wide Analyses Identify KIF5A as a Novel ALS Gene | Neuron | 2018 | 517 |
| 36 | BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease | Neuron | 2004 | 506 |
| 37 | Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS | Acta Neuropathologica | 2013 | 506 |
| 38 | TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics | Neuron | 2017 | 493 |
| 39 | Study of recurrence after surgical resection of intraductal papillary mucinous neoplasm of the pancreas | Gastroenterology | 2002 | 486 |
| 40 | Lewy bodies and parkinsonism in families withparkin mutations | Annals of Neurology | 2001 | 479 |
| 41 | NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo | Journal of Clinical Investigation | 2003 | 476 |
| 42 | Efficacy of Neoadjuvant Chemoradiation, Followed by Liver Transplantation, for Perihilar Cholangiocarcinoma at 12 US Centers | Gastroenterology | 2012 | 475 |
| 43 | Impact of Organizational Leadership on Physician Burnout and Satisfaction | Mayo Clinic Proceedings | 2015 | 471 |
| 44 | Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis | BMJ: British Medical Journal | 2008 | 454 |
| 45 | Accumulation of Pathological Tau Species and Memory Loss in a Conditional Model of Tauopathy | Journal of Neuroscience | 2007 | 438 |
| 46 | Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids | Nature Genetics | 2012 | 428 |
| 47 | Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation | Nature Biomedical Engineering | 2020 | 415 |
| 48 | Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains | Neurobiology of Disease | 2002 | 406 |
| 49 | Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study | Lancet Oncology, The | 2010 | 390 |
| 50 | An autoradiographic evaluation of AV-1451 Tau PET in dementia | Acta Neuropathologica Communications | 2016 | 388 |
