| # | Title | Journal | Year | Citations |
|---|
| 1 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 2 | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease | Nature Genetics | 2013 | 3,741 |
| 3 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 4 | Crowdfunding: Tapping the right crowd | Journal of Business Venturing | 2014 | 1,762 |
| 5 | Variation in FTO contributes to childhood obesity and severe adult obesity | Nature Genetics | 2007 | 1,390 |
| 6 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
| 7 | PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway | Nature Medicine | 2001 | 1,075 |
| 8 | The genome of the blood fluke Schistosoma mansoni | Nature | 2009 | 945 |
| 9 | Adipose Tissue in Obesity-Related Inflammation and Insulin Resistance: Cells, Cytokines, and Chemokines | ISRN Inflammation | 2013 | 807 |
| 10 | Sorting out the roles of PPAR in energy metabolism and vascular homeostasis | Journal of Clinical Investigation | 2006 | 779 |
| 11 | The physiology and clinical utility of anti-Müllerian hormone in women | Human Reproduction Update | 2014 | 722 |
| 12 | Neuroplasticity – Exercise-Induced Response of Peripheral Brain-Derived Neurotrophic Factor | Sports Medicine | 2010 | 658 |
| 13 | Cervical-artery dissections: predisposing factors, diagnosis, and outcome | Lancet Neurology, The | 2009 | 650 |
| 14 | Bariatric Surgery Reduces Features of Nonalcoholic Steatohepatitis in Morbidly Obese Patients | Gastroenterology | 2015 | 608 |
| 15 | Dabrafenib plus trametinib in patients with BRAFV600-mutant melanoma brain metastases (COMBI-MB): a multicentre, multicohort, open-label, phase 2 trial | Lancet Oncology, The | 2017 | 561 |
| 16 | Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants | Nature Genetics | 2014 | 475 |
| 17 | Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium | Clinical Microbiology and Infection | 2007 | 455 |
| 18 | Macrophage phenotypes in atherosclerosis | Immunological Reviews | 2014 | 454 |
| 19 | Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study | Lancet, The | 2019 | 449 |
| 20 | Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children | PLoS Medicine | 2011 | 446 |
| 21 | Prospective Study of the Long-Term Effects of Bariatric Surgery on Liver Injury in Patients Without Advanced Disease | Gastroenterology | 2009 | 440 |
| 22 | Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease | Nature Genetics | 2009 | 427 |
| 23 | Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease | Atherosclerosis | 2014 | 419 |
| 24 | Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis | Hepatology | 2008 | 413 |
| 25 | The Residual Risk Reduction Initiative: A Call to Action to Reduce Residual Vascular Risk in Patients with Dyslipidemia | American Journal of Cardiology | 2008 | 371 |
| 26 | Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission | Lancet, The | 2013 | 370 |
| 27 | Improvement of Cognitive Function by Mental and/or Individualized Aerobic Training in Healthy Elderly Subjects | International Journal of Sports Medicine | 2002 | 342 |
| 28 | Bacteriome and Mycobiome Interactions Underscore Microbial Dysbiosis in Familial Crohn’s Disease | MBio | 2016 | 335 |
| 29 | Viruses and thyroiditis: an update | Virology Journal | 2009 | 327 |
| 30 | Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 310 |
| 31 | Design and implementation of the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study | International Journal of Obesity | 2008 | 299 |
| 32 | Neurotrophic factors in Alzheimer’s disease: role of axonal transport | Genes, Brain and Behavior | 2008 | 298 |
| 33 | New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism | Nature Genetics | 2013 | 293 |
| 34 | Antibacterial activities of inorganic agents on six bacteria associated with oral infections by two susceptibility tests | International Journal of Antimicrobial Agents | 2006 | 291 |
| 35 | Screening for pulmonary arterial hypertension in patients with systemic sclerosis: Clinical characteristics at diagnosis and long‐term survival | Arthritis and Rheumatism | 2011 | 291 |
| 36 | Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes | Nature Genetics | 2005 | 290 |
| 37 | Improving physical activity assessment in prepubertal children with high-frequency accelerometry monitoring: A methodological issue | Preventive Medicine | 2007 | 289 |
| 38 | Renal and Neurologic Effects of Cadmium, Lead, Mercury, and Arsenic in Children: Evidence of Early Effects and Multiple Interactions at Environmental Exposure Levels | Environmental Health Perspectives | 2006 | 280 |
| 39 | Allogeneic hematopoietic stem cell transplantation for MDS and CMML: recommendations from an international expert panel | Blood | 2017 | 278 |
| 40 | Temporal Trends in Transcatheter Aortic Valve Replacement in France | Journal of the American College of Cardiology | 2017 | 277 |
| 41 | The Natural History of Pediatric Ulcerative Colitis: A Population-Based Cohort Study | American Journal of Gastroenterology | 2009 | 273 |
| 42 | Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens | Nature | 2009 | 273 |
| 43 | Molecular Characterization of New Selective Peroxisome Proliferator-Activated Receptor Modulators With Angiotensin Receptor Blocking Activity | Diabetes | 2005 | 270 |
| 44 | PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis | Journal of Hepatology | 2015 | 270 |
| 45 | High efficacy and safety profile of fractionated doses of Mylotarg as induction therapy in patients with relapsed acute myeloblastic leukemia: a prospective study of the alfa group | Leukemia | 2007 | 260 |
| 46 | A novel Alzheimer disease locus located near the gene encoding tau protein | Molecular Psychiatry | 2016 | 260 |
| 47 | Physical and training characteristics of top-class marathon runners | Medicine and Science in Sports and Exercise | 2001 | 253 |
| 48 | Composition of bone and apatitic biomaterials as revealed by intravital Raman microspectroscopy | Bone | 2005 | 249 |
| 49 | International Working Group consensus response evaluation criteria in lymphoma (RECIL 2017) | Annals of Oncology | 2017 | 249 |
| 50 | Characterization of endocytosis of transferrin-coated PLGA nanoparticles by the blood–brain barrier | International Journal of Pharmaceutics | 2009 | 247 |
