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Top Articles

#TitleJournalYearCitations
1A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic MoleculesJournal of the American Chemical Society199512,116
2Caspases: Enemies WithinJournal of the American Chemical Society19986,039
3Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy20164,701
4Role of AMP-activated protein kinase in mechanism of metformin actionJournal of Clinical Investigation20014,597
5Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94Journal of Clinical Investigation19964,132
6Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosisNature19953,863
7Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fracturesLancet, The19963,496
8Viral dynamics in human immunodeficiency virus type 1 infectionNature19953,369
9The Many Roles for Fluorine in Medicinal ChemistryJournal of Medicinal Chemistry20082,993
10NMR View: A computer program for the visualization and analysis of NMR dataJournal of Biomolecular NMR19942,914
11Fast, efficient generation of high-quality atomic charges. AM1-BCC model: II. Parameterization and validationJournal of Computational Chemistry20022,641
12Random Forest:  A Classification and Regression Tool for Compound Classification and QSAR ModelingJournal of Chemical Information and Computer Sciences20032,582
13A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytesNature19922,397
14Heterologous protection against influenza by injection of DNA encoding a viral proteinScience19932,262
15The Mechanisms of Action of PPARsAnnual Review of Medicine20022,256
16Caspases: killer proteasesTrends in Biochemical Sciences19972,182
17Human ICE/CED-3 Protease NomenclatureCell19962,091
18A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone ReleaseScience19961,915
19A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme BJournal of Biological Chemistry19971,883
20hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during ImmortalizationCell19971,689
21Newer Classification and Regression Tree Techniques: Bagging and Random Forests for Ecological PredictionEcosystems20061,665
22Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomesNature Medicine20151,592
23Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor AgonistsScience20021,573
24HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokineNature Medicine20001,497
25Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trialLancet Oncology, The20051,400
26Key green chemistry research areas—a perspective from pharmaceutical manufacturersGreen Chemistry20071,371
27Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsinNature19861,284
28Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.Proceedings of the National Academy of Sciences of the United States of America19931,256
29Genetics of gene expression and its effect on diseaseNature20081,209
30Biochemistry of EndotoxinsAnnual Review of Biochemistry19901,204
31LDL-receptor-related proteins in Wnt signal transductionNature20001,199
32What is the true solubility advantage for amorphous pharmaceuticals?Nature20001,186
33Which GABAA-receptor subtypes really occur in the brain?Trends in Neurosciences19961,123
34Inhibitors of Strand Transfer That Prevent Integration and Inhibit HIV-1 Replication in CellsScience20001,088
35The Effect of Finasteride in Men with Benign Prostatic HyperplasiaNew England Journal of Medicine19921,068
36Structure and Function of G Protein-Coupled ReceptorsAnnual Review of Biochemistry19941,041
37MMFF VI. MMFF94s option for energy minimization studiesJournal of Computational Chemistry19991,033
38In vivo emergence of HIV-1 variants resistant to multiple protease inhibitorsNature19951,023
39Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent MechanismsPLoS ONE20121,022
40Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin SensitivityJournal of Biological Chemistry20041,018
41An interleukin 1 like factor stimulates bone resorption in vitroNature19831,017
42Autophagy in malignant transformation and cancer progressionEMBO Journal20151,012
43Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissuesMolecular Brain Research19971,005
44The Metabolic Syndrome and 11-Year Risk of Incident Cardiovascular Disease in the Atherosclerosis Risk in Communities StudyDiabetes Care2005988
45An integrative genomics approach to infer causal associations between gene expression and diseaseNature Genetics2005967
46Mechanistic investigation of ionization suppression in electrospray ionizationJournal of the American Society for Mass Spectrometry2000959
47The current state of serum biomarkers of hepatotoxicityToxicology2008945
48Merck molecular force field. II. MMFF94 van der Waals and electrostatic parameters for intermolecular interactionsJournal of Computational Chemistry1996941
49Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver diseaseNature Genetics2014938
50AMPK: An Emerging Drug Target for Diabetes and the Metabolic SyndromeCell Metabolism2009925