# | Title | Journal | Year | Citations |
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1 | A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules | Journal of the American Chemical Society | 1995 | 12,116 |
2 | Caspases: Enemies Within | Journal of the American Chemical Society | 1998 | 6,039 |
3 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
4 | Role of AMP-activated protein kinase in mechanism of metformin action | Journal of Clinical Investigation | 2001 | 4,597 |
5 | Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94 | Journal of Clinical Investigation | 1996 | 4,132 |
6 | Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis | Nature | 1995 | 3,863 |
7 | Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures | Lancet, The | 1996 | 3,496 |
8 | Viral dynamics in human immunodeficiency virus type 1 infection | Nature | 1995 | 3,369 |
9 | The Many Roles for Fluorine in Medicinal Chemistry | Journal of Medicinal Chemistry | 2008 | 2,993 |
10 | NMR View: A computer program for the visualization and analysis of NMR data | Journal of Biomolecular NMR | 1994 | 2,914 |
11 | Fast, efficient generation of high-quality atomic charges. AM1-BCC model: II. Parameterization and validation | Journal of Computational Chemistry | 2002 | 2,641 |
12 | Random Forest: A Classification and Regression Tool for Compound Classification and QSAR Modeling | Journal of Chemical Information and Computer Sciences | 2003 | 2,582 |
13 | A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes | Nature | 1992 | 2,397 |
14 | Heterologous protection against influenza by injection of DNA encoding a viral protein | Science | 1993 | 2,262 |
15 | The Mechanisms of Action of PPARs | Annual Review of Medicine | 2002 | 2,256 |
16 | Caspases: killer proteases | Trends in Biochemical Sciences | 1997 | 2,182 |
17 | Human ICE/CED-3 Protease Nomenclature | Cell | 1996 | 2,091 |
18 | A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release | Science | 1996 | 1,915 |
19 | A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B | Journal of Biological Chemistry | 1997 | 1,883 |
20 | hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization | Cell | 1997 | 1,689 |
21 | Newer Classification and Regression Tree Techniques: Bagging and Random Forests for Ecological Prediction | Ecosystems | 2006 | 1,665 |
22 | Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes | Nature Medicine | 2015 | 1,592 |
23 | Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists | Science | 2002 | 1,573 |
24 | HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine | Nature Medicine | 2000 | 1,497 |
25 | Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial | Lancet Oncology, The | 2005 | 1,400 |
26 | Key green chemistry research areas—a perspective from pharmaceutical manufacturers | Green Chemistry | 2007 | 1,371 |
27 | Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin | Nature | 1986 | 1,284 |
28 | Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 1,256 |
29 | Genetics of gene expression and its effect on disease | Nature | 2008 | 1,209 |
30 | Biochemistry of Endotoxins | Annual Review of Biochemistry | 1990 | 1,204 |
31 | LDL-receptor-related proteins in Wnt signal transduction | Nature | 2000 | 1,199 |
32 | What is the true solubility advantage for amorphous pharmaceuticals? | Nature | 2000 | 1,186 |
33 | Which GABAA-receptor subtypes really occur in the brain? | Trends in Neurosciences | 1996 | 1,123 |
34 | Inhibitors of Strand Transfer That Prevent Integration and Inhibit HIV-1 Replication in Cells | Science | 2000 | 1,088 |
35 | The Effect of Finasteride in Men with Benign Prostatic Hyperplasia | New England Journal of Medicine | 1992 | 1,068 |
36 | Structure and Function of G Protein-Coupled Receptors | Annual Review of Biochemistry | 1994 | 1,041 |
37 | MMFF VI. MMFF94s option for energy minimization studies | Journal of Computational Chemistry | 1999 | 1,033 |
38 | In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors | Nature | 1995 | 1,023 |
39 | Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms | PLoS ONE | 2012 | 1,022 |
40 | Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin Sensitivity | Journal of Biological Chemistry | 2004 | 1,018 |
41 | An interleukin 1 like factor stimulates bone resorption in vitro | Nature | 1983 | 1,017 |
42 | Autophagy in malignant transformation and cancer progression | EMBO Journal | 2015 | 1,012 |
43 | Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues | Molecular Brain Research | 1997 | 1,005 |
44 | The Metabolic Syndrome and 11-Year Risk of Incident Cardiovascular Disease in the Atherosclerosis Risk in Communities Study | Diabetes Care | 2005 | 988 |
45 | An integrative genomics approach to infer causal associations between gene expression and disease | Nature Genetics | 2005 | 967 |
46 | Mechanistic investigation of ionization suppression in electrospray ionization | Journal of the American Society for Mass Spectrometry | 2000 | 959 |
47 | The current state of serum biomarkers of hepatotoxicity | Toxicology | 2008 | 945 |
48 | Merck molecular force field. II. MMFF94 van der Waals and electrostatic parameters for intermolecular interactions | Journal of Computational Chemistry | 1996 | 941 |
49 | Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease | Nature Genetics | 2014 | 938 |
50 | AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome | Cell Metabolism | 2009 | 925 |