| Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen | Nature | 2000 | 3.4K |
| Removing electroencephalographic artifacts by blind source separation | Psychophysiology | 2000 | 2.1K |
| Calcium channels activated by hydrogen peroxide mediate abscisic acid signalling in guard cells | Nature | 2000 | 1.7K |
| Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders | Science | 2000 | 1.5K |
| High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation | Journal of Neuroscience | 2000 | 1.5K |
| Electrophysiology reveals semantic memory use in language comprehension | Trends in Cognitive Sciences | 2000 | 1.5K |
| Guidelines for using human event-related potentials to study cognition: Recording standards and publication criteria | Psychophysiology | 2000 | 1.5K |
| Comparative genomics of the eukaryotes | Science | 2000 | 1.4K |
| Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase | Nature | 2000 | 1.2K |
| Aberrant CpG-island methylation has non-random and tumour-type-specific patterns | Nature Genetics | 2000 | 1.1K |
| Topological and energetic factors: what determines the structural details of the transition state ensemble and "en-route" intermediates for protein folding? An investigation for small globular proteins | Journal of Molecular Biology | 2000 | 982 |
| The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant | Nature Cell Biology | 2000 | 875 |
| Activation tagging in Arabidopsis | Plant Physiology | 2000 | 813 |
| Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers | Radiology | 2000 | 805 |
| The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 795 |
| The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling | Seminars in Immunology | 2000 | 773 |
| HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function | Journal of Experimental Medicine | 2000 | 768 |
| Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers | Journal of Experimental Medicine | 2000 | 743 |
| SHATTERPROOF MADS-box genes control seed dispersal in Arabidopsis | Nature | 2000 | 682 |
| The MACHO Project: Microlensing Results from 5.7 Years of Large Magellanic Cloud Observations | Astrophysical Journal | 2000 | 650 |
| A functional-phylogenetic classification system for transmembrane solute transporters | Microbiology and Molecular Biology Reviews | 2000 | 643 |
| Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders | Journal of Affective Disorders | 2000 | 623 |
| Quality of life in individuals with anxiety disorders | American Journal of Psychiatry | 2000 | 610 |
| Reduced genetic variation and the success of an invasive species | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 609 |
| Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis | Nature Cell Biology | 2000 | 599 |
