| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,992 |
| 2 | Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 3,349 |
| 3 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,676 |
| 4 | Interpreting the Clinical Importance of Treatment Outcomes in Chronic Pain Clinical Trials: IMMPACT Recommendations | Journal of Pain | 2008 | 2,654 |
| 5 | COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up | Journal of the American College of Cardiology | 2020 | 2,484 |
| 6 | Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis | Nature Reviews Cancer | 2007 | 2,442 |
| 7 | The Patient-Reported Outcomes Measurement Information System (PROMIS) | Medical Care | 2007 | 2,419 |
| 8 | Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice | Science | 2005 | 2,235 |
| 9 | Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 | Intensive Care Medicine | 2008 | 2,094 |
| 10 | 2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis | Arthritis and Rheumatology | 2016 | 2,003 |
| 11 | Percutaneous Repair or Surgery for Mitral Regurgitation | New England Journal of Medicine | 2011 | 1,868 |
| 12 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,855 |
| 13 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,804 |
| 14 | Recommended methods for determining responsiveness and minimally important differences for patient-reported outcomes | Journal of Clinical Epidemiology | 2008 | 1,782 |
| 15 | REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants | American Journal of Human Genetics | 2016 | 1,743 |
| 16 | Definition, evaluation, and classification of renal osteodystrophy: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO) | Kidney International | 2006 | 1,623 |
| 17 | Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1) | Lancet, The | 2008 | 1,596 |
| 18 | Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma | Nature Genetics | 2015 | 1,588 |
| 19 | Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial | Lancet, The | 2009 | 1,318 |
| 20 | High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice | Cell Metabolism | 2007 | 1,301 |
| 21 | Oligomeric and Fibrillar Species of Amyloid-β Peptides Differentially Affect Neuronal Viability | Journal of Biological Chemistry | 2002 | 1,299 |
| 22 | Mapping genomic loci implicates genes and synaptic biology in schizophrenia | Nature | 2022 | 1,236 |
| 23 | Genome-wide association study identifies 74 loci associated with educational attainment | Nature | 2016 | 1,233 |
| 24 | The Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System: properties, applications, and interpretation | Health and Quality of Life Outcomes | 2003 | 1,181 |
| 25 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,165 |
| 26 | Guidelines of care for the management of psoriasis and psoriatic arthritis | Journal of the American Academy of Dermatology | 2008 | 1,147 |
| 27 | Common variants on chromosome 6p22.1 are associated with schizophrenia | Nature | 2009 | 1,072 |
| 28 | Impact of Cancer-Related Fatigue on the Lives of Patients: New Findings From the Fatigue Coalition | Oncologist | 2000 | 1,060 |
| 29 | Identification of loci associated with schizophrenia by genome-wide association and follow-up | Nature Genetics | 2008 | 989 |
| 30 | Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial | Lancet, The | 2006 | 986 |
| 31 | Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation | New England Journal of Medicine | 2015 | 984 |
| 32 | The Self–Stigma of Mental Illness: Implications for Self–Esteem and Self–Efficacy | Journal of Social and Clinical Psychology | 2006 | 973 |
| 33 | 2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis | Arthritis Care and Research | 2016 | 929 |
| 34 | An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin | Science | 1998 | 915 |
| 35 | In Vitro Characterization of Conditions for Amyloid-β Peptide Oligomerization and Fibrillogenesis | Journal of Biological Chemistry | 2003 | 898 |
| 36 | The Meter of Metabolism | Cell | 2008 | 886 |
| 37 | Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects | Nature Genetics | 2017 | 884 |
| 38 | Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat | Clinical Microbiology Reviews | 2009 | 802 |
| 39 | The worldwide emergence of plasmid-mediated quinolone resistance | Lancet Infectious Diseases, The | 2006 | 789 |
| 40 | The evolutionary history of 2,658 cancers | Nature | 2020 | 755 |
| 41 | Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci | Nature Genetics | 2018 | 706 |
| 42 | NovoTTF-100A versus physician’s choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality | European Journal of Cancer | 2012 | 701 |
| 43 | Breast Cancer—Major changes in the American Joint Committee on Cancer eighth edition cancer staging manual | Ca-A Cancer Journal for Clinicians | 2017 | 688 |
| 44 | Combining Anchor and Distribution-Based Methods to Derive Minimal Clinically Important Differences on the Functional Assessment of Cancer Therapy (FACT) Anemia and Fatigue Scales | Journal of Pain and Symptom Management | 2002 | 683 |
| 45 | Fatigue in cancer patients compared with fatigue in the general United States population | Cancer | 2002 | 680 |
| 46 | A Prospective, Multi-institutional, Pathologist-Based Assessment of 4 Immunohistochemistry Assays for PD-L1 Expression in Non–Small Cell Lung Cancer | JAMA Oncology | 2017 | 674 |
| 47 | Prevalence in the United States of aac(6 ′ ) - Ib - cr Encoding a Ciprofloxacin-Modifying Enzyme | Antimicrobial Agents and Chemotherapy | 2006 | 673 |
| 48 | A case for including spirituality in quality of life measurement in oncology | Psycho-Oncology | 1999 | 648 |
| 49 | American Cancer Society Guidelines for Breast Cancer Screening: Update 2003 | Ca-A Cancer Journal for Clinicians | 2003 | 642 |
| 50 | Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study | Lancet, The | 2022 | 641 |
