| # | Title | Journal | Year | Citations |
|---|
| 1 | Alectinib versus crizotinib in patients with ALK -positive non-small-cell lung cancer (J-ALEX): an open-label, randomised phase 3 trial | Lancet, The | 2017 | 753 |
| 2 | Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study | Lancet Oncology, The | 2014 | 631 |
| 3 | A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model | Nature Medicine | 2012 | 407 |
| 4 | Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation | Nature Medicine | 1999 | 355 |
| 5 | Safety and efficacy of satralizumab monotherapy in neuromyelitis optica spectrum disorder: a randomised, double-blind, multicentre, placebo-controlled phase 3 trial | Lancet Neurology, The | 2020 | 278 |
| 6 | Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease | Blood | 2009 | 257 |
| 7 | Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors | Cancer Cell | 2014 | 238 |
| 8 | Nemolizumab in patients with moderate-to-severe atopic dermatitis: Randomized, phase II, long-term extension study | Journal of Allergy and Clinical Immunology | 2018 | 195 |
| 9 | Integrated classification of lung tumors and cell lines by expression profiling | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 142 |
| 10 | Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 141 |
| 11 | The response of Parp knockout mice against DNA damaging agents | Mutation Research - Reviews in Mutation Research | 2000 | 115 |
| 12 | A low CD34+ cell dose results in higher mortality and poorer survival after blood or marrow stem cell transplantation from HLA-identical siblings: should 2 × 106 CD34+ cells/kg be considered the minimum threshold? | Bone Marrow Transplantation | 2000 | 98 |
| 13 | Pregnancy outcomes after exposure to tocilizumab: A retrospective analysis of 61 patients in Japan | Modern Rheumatology | 2016 | 79 |
| 14 | The complement C5 inhibitor crovalimab in paroxysmal nocturnal hemoglobinuria | Blood | 2020 | 73 |
| 15 | Brief Report: Leucine‐Rich α2‐Glycoprotein as a Potential Biomarker for Joint Inflammation During Anti–Interleukin‐6 Biologic Therapy in Rheumatoid Arthritis | Arthritis and Rheumatology | 2015 | 71 |
| 16 | Spi? selection: An efficient method to detect ?-ray-induced deletions in transgenic mice | Arthritis and Rheumatology | 1999 | 57 |
| 17 | Involvement of parathyroid hormone-related protein in experimental cachexia induced by a human lung cancer-derived cell line established from a bone metastasis specimen | International Journal of Cancer | 2001 | 55 |
| 18 | Selectively crosslinked hyaluronic acid hydrogels for sustained release formulation of erythropoietin | Journal of Biomedical Materials Research - Part A | 2006 | 50 |
| 19 | B cells and autoimmune liver diseases | Autoimmunity Reviews | 2006 | 49 |
| 20 | Comparison of marrow and blood cell yields from the same donors in a double-blind, randomized study of allogeneic marrow vs blood stem cell transplantation | Bone Marrow Transplantation | 2000 | 44 |
| 21 | Interferon‐α enhances CD317 expression and the antitumor activity of anti‐CD317 monoclonal antibody in renal cell carcinoma xenograft models | Cancer Science | 2008 | 41 |
| 22 | Alectinib Resistance in ALK-Rearranged Lung Cancer by Dual Salvage Signaling in a Clinically Paired Resistance Model | Molecular Cancer Research | 2019 | 41 |
| 23 | Intermittent schedules of the oral RAF–MEK inhibitor CH5126766/VS-6766 in patients with RAS/RAF-mutant solid tumours and multiple myeloma: a single-centre, open-label, phase 1 dose-escalation and basket dose-expansion study | Lancet Oncology, The | 2020 | 41 |
| 24 | Identification of deamidation and isomerization sites on pharmaceutical recombinant antibody using H218O | Analytical Biochemistry | 2007 | 40 |
| 25 | Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3 | Laboratory Investigation | 2012 | 37 |
| 26 | Selective SGLT2 inhibition by tofogliflozin reduces renal glucose reabsorption under hyperglycemic but not under hypo- or euglycemic conditions in rats | American Journal of Physiology - Endocrinology and Metabolism | 2013 | 36 |
| 27 | Impact of bevacizumab in combination with erlotinib on EGFR‐mutated non–small cell lung cancer xenograft models with T790M mutation or MET amplification | International Journal of Cancer | 2016 | 35 |
| 28 | Effect of combination therapy with recombinant human granulocyte colony-stimulating factor (rG-CSF) and antibiotics in nentropenic mice unresponsive to antibiotics alone | Journal of Antimicrobial Chemotherapy | 1991 | 29 |
| 29 | Pinacidil but not Nicorandil Opens ATP-sensitive K+Channels and Protects Against Simulated Ischemia in Rabbit Myocytes | Journal of Molecular and Cellular Cardiology | 1997 | 28 |
| 30 | Identification and characterization of the cell-associated binding protein for urinary trypsin inhibitor | BBA - Proteins and Proteomics | 1998 | 27 |
| 31 | Comparison of tocilizumab and tumour necrosis factor inhibitors in rheumatoid arthritis: a retrospective analysis of 1603 patients managed in routine clinical practice | Clinical Rheumatology | 2015 | 27 |
| 32 | Sustainable Efficacy of Switching From Intravenous to Subcutaneous Tocilizumab Monotherapy in Patients With Rheumatoid Arthritis | Arthritis Care and Research | 2015 | 26 |
| 33 | Performance of the new 2011 ACR/EULAR remission criteria with tocilizumab using the phase IIIb study TAMARA as an example and their comparison with traditional remission criteria | Annals of the Rheumatic Diseases | 2011 | 25 |
| 34 | The anti-ischemic effects of CP-060S during pacing-induced ischemia in anesthetized dogs | European Journal of Pharmacology | 1999 | 24 |
| 35 | Optimal timing for collection of PBPC after glycosylated G-CSF administration | Bone Marrow Transplantation | 1998 | 22 |
| 36 | Growth Hormone Has Dual Stage-Specific Effects on the Differentiation of 3T3-L1 Preadipocytes | Journal of Biochemistry | 2002 | 22 |
| 37 | Antimicrobial activities of thiolactomycin against gram-negative anaerobes associated with periodontal disease | Oral Microbiology and Immunology | 1990 | 21 |
| 38 | Humanization and Simultaneous Optimization of Monoclonal Antibody | Methods in Molecular Biology | 2014 | 21 |
| 39 | Determination of 22-oxacalcitriol, a new analog of 1α,25-dihydroxyvitamin D3, in human serum by liquid chromatography–mass spectrometry | Biomedical Applications | 1998 | 20 |
| 40 | Mechanism of uricosuric action of AA-193 in DBA/2N mice | Journal of Pharmacology and Experimental Therapeutics | 1990 | 18 |
| 41 | 22-oxacalcitriol suppresses 25-hydroxycholecalciferol-1α-hydroxylase in rat kidney | Biochemical and Biophysical Research Communications | 1992 | 16 |
| 42 | Adrenomedullin synergistically interacts with endogenous vasodilators in rats: a possible role of KATP channels | European Journal of Pharmacology | 1998 | 16 |
| 43 | Hepatocyte growth factor mobilizes and recruits hematopoietic progenitor cells into liver through a stem cell factor‐mediated mechanism | Hepatology Research | 2010 | 15 |
| 44 | Testing G-CSF responsiveness predicts the individual susceptibility to infection and consecutive treatment in recipients of high-dose chemotherapy | Blood | 2011 | 15 |
| 45 | A56: Macrophage Activation Syndrome in Patients With Systemic Juvenile Idiopathic Arthritis Treated With Tocilizumab | Arthritis and Rheumatology | 2014 | 14 |
| 46 | Phase I/II study of vemurafenib in patients with unresectable or recurrent melanoma with BRAFV600 mutations | Journal of Dermatology | 2015 | 14 |
| 47 | Humanization and Simultaneous Optimization of Monoclonal Antibody | Methods in Molecular Biology | 2019 | 14 |
| 48 | Hypouricemic and uricosuric actions of AA-193 in a hyperuricemic rat model | Metabolism: Clinical and Experimental | 1994 | 13 |
| 49 | Targeting antigen-specific receptors on B lymphocytes to generate high yields of specific monoclonal antibodies directed against biologically active lower antigenic peptides within presenilin 1 | Journal of Immunological Methods | 2001 | 13 |
| 50 | Increased EGFR Phosphorylation Correlates with Higher Programmed Death Ligand-1 Expression: Analysis of TKI-Resistant Lung Cancer Cell Lines | BioMed Research International | 2017 | 13 |
