| # | Title | Journal | Year | Citations |
|---|
| 1 | Lung cancer: current therapies and new targeted treatments | Lancet, The | 2017 | 2,267 |
| 2 | The Polycomb group protein EZH2 directly controls DNA methylation | Nature | 2006 | 1,964 |
| 3 | Mechanisms and functions of p38 MAPK signalling | Biochemical Journal | 2010 | 1,342 |
| 4 | Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment | Cancer Cell | 2017 | 1,282 |
| 5 | Afatinib versus gefitinib as first-line treatment of patients with EGFR mutation-positive non-small-cell lung cancer (LUX-Lung 7): a phase 2B, open-label, randomised controlled trial | Lancet Oncology, The | 2016 | 950 |
| 6 | Epithelial-Mesenchymal Transition in Breast Cancer Relates to the Basal-like Phenotype | Cancer Research | 2008 | 934 |
| 7 | NASH limits anti-tumour surveillance in immunotherapy-treated HCC | Nature | 2021 | 649 |
| 8 | Current Challenges in Cancer Treatment | Clinical Therapeutics | 2016 | 549 |
| 9 | Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the ‘cutaneous variant’1 | British Journal of Haematology | 2004 | 535 |
| 10 | Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer | Nature Genetics | 2013 | 493 |
| 11 | Epithelial cell polarity, stem cells and cancer | Nature Reviews Cancer | 2012 | 476 |
| 12 | Tissue damage and senescence provide critical signals for cellular reprogramming in vivo | Science | 2016 | 466 |
| 13 | Afatinib versus gefitinib in patients with EGFR mutation-positive advanced non-small-cell lung cancer: overall survival data from the phase IIb LUX-Lung 7 trial | Annals of Oncology | 2017 | 425 |
| 14 | EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations | Leukemia | 2012 | 409 |
| 15 | Outcome in Hodgkin's Lymphoma Can Be Predicted from the Presence of Accompanying Cytotoxic and Regulatory T Cells | Clinical Cancer Research | 2005 | 401 |
| 16 | Genome-wide association studies identify four ER negative–specific breast cancer risk loci | Nature Genetics | 2013 | 374 |
| 17 | Prognostic Significance of Basal-Like Phenotype and Fascin Expression in Node-Negative Invasive Breast Carcinomas | Clinical Cancer Research | 2006 | 318 |
| 18 | A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging | Nature Genetics | 2009 | 317 |
| 19 | Control of cell proliferation pathways by microRNAs | Cell Cycle | 2008 | 304 |
| 20 | Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets. Report of the BIOMED-2 Concerted Action BHM4-CT98-3936 | Leukemia | 2007 | 292 |
| 21 | Genetic Profiling of Epithelial Cells Expressing E-Cadherin Repressors Reveals a Distinct Role for Snail, Slug, and E47 Factors in Epithelial-Mesenchymal Transition | Cancer Research | 2006 | 285 |
| 22 | Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma | Cancer Cell | 2016 | 281 |
| 23 | Improved reliability of lymphoma diagnostics via PCR-based clonality testing: — Report of the BIOMED-2 Concerted Action BHM4-CT98-3936 | Leukemia | 2007 | 279 |
| 24 | A High-Throughput Study in Melanoma Identifies Epithelial-Mesenchymal Transition as a Major Determinant of Metastasis | Cancer Research | 2007 | 274 |
| 25 | Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome | Nature Genetics | 2012 | 270 |
| 26 | Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer | Nature Medicine | 2019 | 259 |
| 27 | Genome-wide association analysis identifies three new breast cancer susceptibility loci | Nature Genetics | 2012 | 256 |
| 28 | Splenic marginal zone lymphoma proposals for a revision of diagnostic, staging and therapeutic criteria | Leukemia | 2008 | 244 |
| 29 | Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead | Carcinogenesis | 2015 | 239 |
| 30 | AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest | Nature Cell Biology | 2015 | 223 |
| 31 | Transcription Profiling of Platelet-Derived Growth Factor-B-Deficient Mouse Embryos Identifies RGS5 as a Novel Marker for Pericytes and Vascular Smooth Muscle Cells | American Journal of Pathology | 2003 | 215 |
| 32 | GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer | Gut | 2017 | 212 |
| 33 | Peripheral T-cell Lymphomas With a Follicular Growth Pattern are Derived From Follicular Helper T Cells (TFH) and may Show Overlapping Features With Angioimmunoblastic T-cell Lymphomas | American Journal of Surgical Pathology | 2009 | 189 |
| 34 | Targeting Mitotic Exit Leads to Tumor Regression In Vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ Phosphatase | Cancer Cell | 2010 | 188 |
| 35 | Tisagenlecleucel in adult relapsed or refractory follicular lymphoma: the phase 2 ELARA trial | Nature Medicine | 2022 | 182 |
| 36 | CDK6 as a key regulator of hematopoietic and leukemic stem cell activation | Blood | 2015 | 179 |
| 37 | Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B-cell lymphomas: a multicenter study of the Splenic B-Cell Lymphoma Group | Blood | 2010 | 174 |
| 38 | Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome | Blood | 2011 | 173 |
| 39 | Intracellular autofluorescence: a biomarker for epithelial cancer stem cells | Nature Methods | 2014 | 170 |
| 40 | Inhibition of CD47 Effectively Targets Pancreatic Cancer Stem Cells via Dual Mechanisms | Clinical Cancer Research | 2015 | 170 |
| 41 | Inhibition of De Novo NAD + Synthesis by Oncogenic URI Causes Liver Tumorigenesis through DNA Damage | Cancer Cell | 2014 | 162 |
| 42 | Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells | Immunity | 2020 | 157 |
| 43 | Analysis ofBRCA1andBRCA2genes in Spanish breast/ovarian cancer patients: A high proportion of mutations unique to Spain and evidence of founder effects | Human Mutation | 2003 | 154 |
| 44 | What We Have Learned About Pancreatic Cancer From Mouse Models | Gastroenterology | 2012 | 151 |
| 45 | Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma | Nature Medicine | 2016 | 150 |
| 46 | LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy | Nature Communications | 2019 | 150 |
| 47 | A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells | Nature Communications | 2016 | 149 |
| 48 | Gasdermin-B Promotes Invasion and Metastasis in Breast Cancer Cells | PLoS ONE | 2014 | 141 |
| 49 | BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping | Nature Structural and Molecular Biology | 2010 | 140 |
| 50 | Immunohistochemical characteristics defined by tissue microarray of hereditary breast cancer not attributable to BRCA1 or BRCA2 mutations: differences from breast carcinomas arising in BRCA1 and BRCA2 mutation carriers | Clinical Cancer Research | 2003 | 136 |
