| # | Title | Journal | Year | Citations |
|---|
| 1 | Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity | Nature | 1962 | 7,566 |
| 2 | Probability-based protein identification by searching sequence databases using mass spectrometry data | Electrophoresis | 1999 | 7,555 |
| 3 | Instability and decay of the primary structure of DNA | Nature | 1993 | 5,020 |
| 4 | Multiplexed Protein Quantitation in Saccharomyces cerevisiae Using Amine-reactive Isobaric Tagging Reagents | Molecular and Cellular Proteomics | 2004 | 3,873 |
| 5 | A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif | Nature | 1990 | 3,014 |
| 6 | Statistics notes: Multiple significance tests: the Bonferroni method | BMJ: British Medical Journal | 1995 | 2,989 |
| 7 | Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development | Cell | 1997 | 2,620 |
| 8 | Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences | Nature | 1984 | 2,604 |
| 9 | T antigen is bound to a host protein in SY40-transformed cells | Nature | 1979 | 2,499 |
| 10 | VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia | Journal of Cell Biology | 2003 | 2,483 |
| 11 | Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line | Nucleic Acids Research | 1990 | 2,100 |
| 12 | Comparing methods of measurement: why plotting difference against standard method is misleading | Lancet, The | 1995 | 2,091 |
| 13 | Rapid and efficient cosmid cloning | Nucleic Acids Research | 1981 | 1,970 |
| 14 | A signature motif in transcriptional co-activators mediates binding to nuclear receptors | Nature | 1997 | 1,949 |
| 15 | Phosphatidylinositol-3-OH kinase direct target of Ras | Nature | 1994 | 1,886 |
| 16 | Epstein–Barr virus: 40 years on | Nature Reviews Cancer | 2004 | 1,875 |
| 17 | The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides | Cell | 1986 | 1,746 |
| 18 | Quantitative visualization of DNA G-quadruplex structures in human cells | Nature Chemistry | 2013 | 1,746 |
| 19 | Smoldering and polarized inflammation in the initiation and promotion of malignant disease | Cancer Cell | 2005 | 1,622 |
| 20 | Out of Eden: Stem Cells and Their Niches | Science | 2000 | 1,613 |
| 21 | Statistics Notes: Diagnostic tests 1: sensitivity and specificity | BMJ: British Medical Journal | 1994 | 1,585 |
| 22 | A wilcoxon-type test for trend | Statistics in Medicine | 1985 | 1,582 |
| 23 | Rapid identification of proteins by peptide-mass fingerprinting | Current Biology | 1993 | 1,571 |
| 24 | Detection of elevated levels of tumour‐associated microRNAs in serum of patients with diffuse large B‐cell lymphoma | British Journal of Haematology | 2008 | 1,570 |
| 25 | Mutation selection and the natural history of cancer | Nature | 1975 | 1,486 |
| 26 | Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin | Nature | 1985 | 1,464 |
| 27 | The extended protein kinase C superfamily | Biochemical Journal | 1998 | 1,452 |
| 28 | Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia | Cell | 1997 | 1,435 |
| 29 | Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer | Nature Genetics | 2002 | 1,426 |
| 30 | Statistics notes: Absence of evidence is not evidence of absence | BMJ: British Medical Journal | 1995 | 1,370 |
| 31 | Localization of the gene for familial adenomatous polyposis on chromosome 5 | Nature | 1987 | 1,362 |
| 32 | Enhanced genome annotation using structural profiles in the program 3D-PSSM 1 1Edited by J. Thornton | Journal of Molecular Biology | 2000 | 1,361 |
| 33 | Quality Control by DNA Repair | Science | 1999 | 1,360 |
| 34 | Statistics Notes: Diagnostic tests 2: predictive values | BMJ: British Medical Journal | 1994 | 1,352 |
| 35 | A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia | Nature | 1982 | 1,313 |
| 36 | The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain | Cell | 1993 | 1,301 |
| 37 | Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity | Cell | 1995 | 1,273 |
| 38 | Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation | Nature | 1993 | 1,260 |
| 39 | Environmentally persistent alkylphenolic compounds are estrogenic. | Endocrinology | 1994 | 1,253 |
| 40 | Regulation of transcription by MAP kinase cascades | Current Opinion in Cell Biology | 1996 | 1,240 |
| 41 | Sequence and expression of human estrogen receptor complementary DNA | Science | 1986 | 1,223 |
| 42 | Mechanisms and consequences of activation of protein kinase B/Akt | Current Opinion in Cell Biology | 1998 | 1,222 |
| 43 | Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the Cyclin-Dependent Kinases cdc2, cdk2 and cdk5 | FEBS Journal | 1997 | 1,215 |
| 44 | Human DNA Repair Genes | Science | 2001 | 1,195 |
| 45 | Guidelines for the welfare and use of animals in cancer research | British Journal of Cancer | 2010 | 1,167 |
| 46 | Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2 | Nature | 1987 | 1,161 |
| 47 | Neurotoxins Affecting Neuroexocytosis | Physiological Reviews | 2000 | 1,141 |
| 48 | Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB | Nature | 1997 | 1,114 |
| 49 | Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy | Journal of Experimental Medicine | 2004 | 1,112 |
| 50 | Role of poly(ADP-ribose) formation in DNA repair | Nature | 1992 | 1,086 |
