| # | Title | Journal | Year | Citations |
|---|
| 1 | Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega | Molecular Systems Biology | 2011 | 12,778 |
| 2 | BLAT—The BLAST-Like Alignment Tool | Genome Research | 2002 | 7,227 |
| 3 | The Somatic Genomic Landscape of Glioblastoma | Cell | 2013 | 3,979 |
| 4 | GREAT improves functional interpretation of cis-regulatory regions | Nature Biotechnology | 2010 | 3,789 |
| 5 | A Relationship between Nuclear Black Hole Mass and Galaxy Velocity Dispersion | Astrophysical Journal | 2000 | 3,004 |
| 6 | An early Cenozoic perspective on greenhouse warming and carbon-cycle dynamics | Nature | 2008 | 2,725 |
| 7 | Consensus Statement: Chromosomal Microarray Is a First-Tier Clinical Diagnostic Test for Individuals with Developmental Disabilities or Congenital Anomalies | American Journal of Human Genetics | 2010 | 2,325 |
| 8 | A sensorimotor account of vision and visual consciousness | Behavioral and Brain Sciences | 2001 | 2,295 |
| 9 | tRNAscan-SE On-line: integrating search and context for analysis of transfer RNA genes | Nucleic Acids Research | 2016 | 2,219 |
| 10 | The tRNAscan-SE, snoscan and snoGPS web servers for the detection of tRNAs and snoRNAs | Nucleic Acids Research | 2005 | 2,090 |
| 11 | Biotic homogenization: a few winners replacing many losers in the next mass extinction | Trends in Ecology and Evolution | 1999 | 2,040 |
| 12 | Knowledge-based analysis of microarray gene expression data by using support vector machines | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 2,034 |
| 13 | A new view of the tree of life | Nature Microbiology | 2016 | 1,823 |
| 14 | Crystal Structure of the Ribosome at 5.5 A Resolution | Science | 2001 | 1,789 |
| 15 | LSST: From Science Drivers to Reference Design and Anticipated Data Products | Astrophysical Journal | 2019 | 1,744 |
| 16 | NanoPack: visualizing and processing long-read sequencing data | Bioinformatics | 2018 | 1,713 |
| 17 | Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial | New England Journal of Medicine | 2012 | 1,699 |
| 18 | Hidden Markov Models in Computational Biology | Journal of Molecular Biology | 1994 | 1,660 |
| 19 | THENUCLEAR SPECTROSCOPIC TELESCOPE ARRAY(NuSTAR) HIGH-ENERGY X-RAY MISSION | Astrophysical Journal | 2013 | 1,627 |
| 20 | A Survey of Software-Defined Networking: Past, Present, and Future of Programmable Networks | IEEE Communications Surveys and Tutorials | 2014 | 1,623 |
| 21 | Challenges in the Quest for Keystones | BioScience | 1996 | 1,557 |
| 22 | Star Formation in AEGIS Field Galaxies since z = 1.1: The Dominance of Gradually Declining Star Formation, and the Main Sequence of Star-forming Galaxies | Astrophysical Journal | 2007 | 1,552 |
| 23 | Ultraconserved Elements in the Human Genome | Science | 2004 | 1,496 |
| 24 | Founding events in species invasions: genetic variation, adaptive evolution, and the role of multiple introductions | Molecular Ecology | 2008 | 1,468 |
| 25 | The Bioperl Toolkit: Perl Modules for the Life Sciences | Genome Research | 2002 | 1,427 |
| 26 | The K2 Mission: Characterization and Early Results | Publications of the Astronomical Society of the Pacific | 2014 | 1,344 |
| 27 | The Supernova–Gamma-Ray Burst Connection | Annual Review of Astronomy and Astrophysics | 2006 | 1,330 |
| 28 | Aligning Multiple Genomic Sequences With the Threaded Blockset Aligner | Genome Research | 2004 | 1,290 |
| 29 | Evolutionary and Biomedical Insights from the Rhesus Macaque Genome | Science | 2007 | 1,283 |
| 30 | The Nucleosynthetic Signature of Population III | Astrophysical Journal | 2002 | 1,252 |
| 31 | Formation of galaxies and large-scale structure with cold dark matter | Nature | 1984 | 1,247 |
| 32 | FERMI LARGE AREA TELESCOPE THIRD SOURCE CATALOG | Astrophysical Journal, Supplement Series | 2015 | 1,224 |
| 33 | THEM-σ ANDM-LRELATIONS IN GALACTIC BULGES, AND DETERMINATIONS OF THEIR INTRINSIC SCATTER | Astrophysical Journal | 2009 | 1,220 |
| 34 | Towards complete and error-free genome assemblies of all vertebrate species | Nature | 2021 | 1,139 |
| 35 | Interaction of antibiotics with functional sites in 16S ribosomal RNA | Nature | 1987 | 1,132 |
| 36 | Spatio-temporal correlations and visual signalling in a complete neuronal population | Nature | 2008 | 1,128 |
| 37 | Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE | Science | 2010 | 1,124 |
| 38 | CRISPOR: intuitive guide selection for CRISPR/Cas9 genome editing experiments and screens | Nucleic Acids Research | 2018 | 1,114 |
| 39 | ppCollisions ats=7and 8 TeV with the ATLAS and CMS Experiments">Combined Measurement of the Higgs Boson Mass inppCollisions ats=7and 8 TeV with the ATLAS and CMS Experiments | Physical Review Letters | 2015 | 1,062 |
| 40 | Marine04 Marine Radiocarbon Age Calibration, 0–26 Cal Kyr Bp | Radiocarbon | 2004 | 1,040 |
| 41 | tRNAscan-SE: Searching for tRNA Genes in Genomic Sequences | Methods in Molecular Biology | 2019 | 1,023 |
| 42 | Rapid formation and selective stabilization of synapses for enduring motor memories | Nature | 2009 | 1,016 |
| 43 | Convergence across biomes to a common rain-use efficiency | Nature | 2004 | 968 |
| 44 | The UCSC Genome Browser database: update 2011 | Nucleic Acids Research | 2011 | 958 |
| 45 | brahma: A regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2SWI2 | Cell | 1992 | 955 |
| 46 | Concentrations of Dark Halos from Their Assembly Histories | Astrophysical Journal | 2002 | 953 |
| 47 | Interpreting the Cosmic Infrared Background: Constraints on the Evolution of the Dust‐enshrouded Star Formation Rate | Astrophysical Journal | 2001 | 950 |
| 48 | Iron-limited diatom growth and Si:N uptake ratios in a coastal upwelling regime | Nature | 1998 | 917 |
| 49 | JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles | Nucleic Acids Research | 2022 | 902 |
| 50 | Searching for Dark Matter Annihilation from Milky Way Dwarf Spheroidal Galaxies with Six Years of Fermi Large Area Telescope Data | Physical Review Letters | 2015 | 881 |
