| # | Title | Journal | Year | Citations |
|---|
| 1 | Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations | Nature Genetics | 2015 | 1,965 |
| 2 | Classification of Inflammatory Bowel Disease | Scandinavian Journal of Gastroenterology | 1989 | 1,730 |
| 3 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial | Lancet, The | 2010 | 1,483 |
| 4 | The classification of cancer of the rectum | The Journal of Pathology and Bacteriology | 1932 | 1,373 |
| 5 | Localization of the gene for familial adenomatous polyposis on chromosome 5 | Nature | 1987 | 1,362 |
| 6 | Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders | Journal of Crohn's and Colitis | 2017 | 1,324 |
| 7 | Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations | Lancet, The | 2001 | 1,071 |
| 8 | Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002) | Gut | 2010 | 1,000 |
| 9 | Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease | Nature Genetics | 2017 | 943 |
| 10 | Mapping of a susceptibility locus for Crohn's disease on chromosome 16 | Nature | 1996 | 906 |
| 11 | Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas | Nature Genetics | 2013 | 851 |
| 12 | Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial | Lancet, The | 2011 | 849 |
| 13 | Kirsten ras mutations in patients with colorectal cancer: the ‘RASCAL II’ study | British Journal of Cancer | 2001 | 790 |
| 14 | Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis | Gut | 2004 | 783 |
| 15 | A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21 | Nature Genetics | 2007 | 754 |
| 16 | ECCO Guidelines on Therapeutics in Crohn's Disease: Medical Treatment | Journal of Crohn's and Colitis | 2020 | 741 |
| 17 | The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease | Gastroenterology | 2002 | 670 |
| 18 | Peutz-Jeghers syndrome: a systematic review and recommendations for management | Gut | 2010 | 635 |
| 19 | Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations | Clinical Nutrition | 2012 | 631 |
| 20 | Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts | Gut | 2013 | 630 |
| 21 | Chromosome 5 allele loss in human colorectal carcinomas | Nature | 1987 | 586 |
| 22 | Surgery for colorectal cancer in elderly patients: a systematic review | Lancet, The | 2000 | 547 |
| 23 | Tumour `budding' as an index to estimate the potential of aggressiveness in rectal cancer | Histopathology | 2002 | 536 |
| 24 | A NEW PROGNOSTIC CLASSIFICATION OF RECTAL CANCER | Lancet, The | 1987 | 530 |
| 25 | The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases | Histopathology | 1986 | 528 |
| 26 | A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3 | Nature Genetics | 2008 | 514 |
| 27 | Long-term neoplasia risk after azathioprine treatment in inflammatory bowel disease | Lancet, The | 1994 | 490 |
| 28 | ECCO Guidelines on Therapeutics in Crohn’s Disease: Surgical Treatment | Journal of Crohn's and Colitis | 2020 | 478 |
| 29 | Long-term results of overlapping anterior anal-sphincter repair for obstetric trauma | Lancet, The | 2000 | 474 |
| 30 | Pancolonic indigo carmine dye spraying for the detection of dysplasia in ulcerative colitis | Gut | 2004 | 469 |
| 31 | Slowed conduction in the pudendal nerves in idiopathic (neurogenic) faecal incontinence | British Journal of Surgery | 2005 | 444 |
| 32 | Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience. | Gut | 1993 | 439 |
| 33 | Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study | The Lancet Gastroenterology and Hepatology | 2019 | 431 |
| 34 | Precancer and cancer in extensive ulcerative colitis: findings among 401 patients over 22 years. | Gut | 1990 | 415 |
| 35 | Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis | British Journal of Surgery | 2005 | 412 |
| 36 | Randomised controlled trial of CDP571 antibody to tumour necrosis factor-α in Crohn's disease | Lancet, The | 1997 | 400 |
| 37 | Juvenile polyposis–a precancerous condition | Histopathology | 1988 | 396 |
| 38 | Bowel preparation for colonoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline | Endoscopy | 2013 | 392 |
| 39 | Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease | Gut | 2006 | 379 |
| 40 | Transanal Total Mesorectal Excision | Annals of Surgery | 2017 | 377 |
| 41 | A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis | Gut | 2002 | 375 |
| 42 | Optical diagnosis of small colorectal polyps at routine colonoscopy (Detect InSpect ChAracterise Resect and Discard; DISCARD trial): a prospective cohort study | Lancet Oncology, The | 2009 | 369 |
| 43 | Pudendal nerve damage during labour: prospective study before and after childbirth* | BJOG: an International Journal of Obstetrics and Gynaecology | 1994 | 367 |
| 44 | Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database | Genetics in Medicine | 2020 | 365 |
| 45 | Proctocolectomy with ileal reservoir and anal anastomosis | British Journal of Surgery | 2005 | 355 |
| 46 | The clinical significance of invasion of veins by rectal cancer | British Journal of Surgery | 2005 | 349 |
| 47 | Chemoradiation for the treatment of epidermoid anal cancer: 13-year follow-up of the first randomised UKCCCR Anal Cancer Trial (ACT I) | British Journal of Cancer | 2010 | 348 |
| 48 | Prevention of colorectal cancer by once-only sigmoidoscopy | Lancet, The | 1993 | 347 |
| 49 | Bowel dysfunction in spinal-cord-injury patients | Lancet, The | 1996 | 345 |
| 50 | Bioactive Glass Stimulates the Secretion of Angiogenic Growth Factors and Angiogenesis in Vitro | Tissue Engineering | 2005 | 344 |
