| # | Title | Journal | Year | Citations |
|---|
| 1 | Percutaneous Repair or Surgery for Mitral Regurgitation | New England Journal of Medicine | 2011 | 1,814 |
| 2 | Hospital-acquired renal insufficiency | American Journal of Kidney Diseases | 2002 | 1,676 |
| 3 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial | Lancet, The | 2013 | 1,490 |
| 4 | Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas | Lancet, The | 1995 | 1,327 |
| 5 | High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice | Cell Metabolism | 2007 | 1,265 |
| 6 | A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse | British Journal of Cancer | 2000 | 1,154 |
| 7 | Complications of Transsphenoidal Surgery: Results of a National Survey, Review of the Literature, and Personal Experience | Neurosurgery | 1997 | 898 |
| 8 | Percutaneous Mitral Repair With the MitraClip System | Journal of the American College of Cardiology | 2009 | 852 |
| 9 | Alteplase versus heparin in acute pulmonary embolism: randomised trial assessing right-ventricular function and pulmonary perfusion | Lancet, The | 1993 | 808 |
| 10 | Managing Incidental Findings on Abdominal CT: White Paper of the ACR Incidental Findings Committee | Journal of the American College of Radiology | 2010 | 766 |
| 11 | Percutaneous Mitral Valve Repair Using the Edge-to-Edge Technique | Journal of the American College of Cardiology | 2005 | 693 |
| 12 | Anatomical and clinical characteristics to guide decision making between coronary artery bypass surgery and percutaneous coronary intervention for individual patients: development and validation of SYNTAX score II | Lancet, The | 2013 | 679 |
| 13 | Randomized Comparison of Percutaneous Repair and Surgery for Mitral Regurgitation | Journal of the American College of Cardiology | 2015 | 658 |
| 14 | Loss of Heterozygosity in Normal Tissue Adjacent to Breast Carcinomas | Science | 1996 | 531 |
| 15 | Combination cediranib and olaparib versus olaparib alone for women with recurrent platinum-sensitive ovarian cancer: a randomised phase 2 study | Lancet Oncology, The | 2014 | 523 |
| 16 | The Clinical Impact of Incomplete Left Atrial Appendage Closure With the Watchman Device in Patients With Atrial Fibrillation | Journal of the American College of Cardiology | 2012 | 479 |
| 17 | Effect of the Extent of Surgical Resection on Survival and Quality of Life in Patients with Supratentorial Glioblastomas and Anaplastic Astrocytomas | Neurosurgery | 1987 | 453 |
| 18 | Tumor-infiltrating lymphocytes are a marker for microsatellite instability in colorectal carcinoma | Cancer | 2001 | 440 |
| 19 | 4-Year Results of a Randomized Controlled Trial of Percutaneous Repair Versus Surgery for Mitral Regurgitation | Journal of the American College of Cardiology | 2013 | 411 |
| 20 | Association of Type and Location ofBRCA1andBRCA2Mutations With Risk of Breast and Ovarian Cancer | JAMA - Journal of the American Medical Association | 2015 | 390 |
| 21 | Engineering Bone Regeneration with Bioabsorbable Scaffolds with Novel Microarchitecture | Tissue Engineering | 1999 | 360 |
| 22 | Outcomes With Transcatheter Mitral Valve Repair in the United States | Journal of the American College of Cardiology | 2017 | 333 |
| 23 | New Paradigm for Lymphocyte Granule-mediated Cytotoxicity | Journal of Biological Chemistry | 1996 | 320 |
| 24 | Neonatal Necrotizing Enterocolitis: Clinical Considerations and Pathogenetic Concepts | Pediatric and Developmental Pathology | 2003 | 319 |
| 25 | The influence of surgical trauma on experimental metastasis | Cancer | 1989 | 302 |
| 26 | Cerebral vasospasm and eclampsia. | Stroke | 1988 | 301 |
| 27 | Functional Anatomy of Intra- and Cross-Modal Lexical Tasks | NeuroImage | 2002 | 294 |
| 28 | Coronary artery bypass grafting vs. percutaneous coronary intervention for patients with three-vessel disease: final five-year follow-up of the SYNTAX trial | European Heart Journal | 2014 | 292 |
| 29 | 1-Year Outcomes of Transcatheter Mitral Valve Replacement in Patients With Severe Mitral Annular Calcification | Journal of the American College of Cardiology | 2018 | 288 |
| 30 | Age-related differences in the quality of life of breast carcinoma patients after treatment | Cancer | 1999 | 285 |
| 31 | Comparative trial of prednisone plus aspirin versus aspirin alone in the treatment of anticardiolipin antibody-positive obstetric patients | American Journal of Obstetrics and Gynecology | 1993 | 279 |
| 32 | Incidence, predictors, and clinical outcomes of coronary obstruction following transcatheter aortic valve replacement for degenerative bioprosthetic surgical valves: insights from the VIVID registry | European Heart Journal | 2018 | 269 |
| 33 | The Negative Impact of Incomplete Angiographic Revascularization on Clinical Outcomes and Its Association With Total Occlusions | Journal of the American College of Cardiology | 2013 | 257 |
| 34 | Transcatheter Mitral Valve Replacement in Native Mitral Valve Disease With Severe Mitral Annular Calcification | JACC: Cardiovascular Interventions | 2016 | 257 |
| 35 | Transcatheter Mitral Valve Replacement for Patients With Symptomatic Mitral Regurgitation | Journal of the American College of Cardiology | 2017 | 257 |
| 36 | Effects of treatment on long-term survivors with malignant astrocytomas | Annals of Neurology | 1990 | 253 |
| 37 | Bifidobacterial supplementation reduces the incidence of necrotizing enterocolitis in a neonatal rat model | Gastroenterology | 1999 | 251 |
| 38 | Pelvic floor electrical stimulation in the treatment of genuine stress incontinence: A multicenter, placebo-controlled trial | American Journal of Obstetrics and Gynecology | 1995 | 248 |
| 39 | ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B | Journal of Biological Chemistry | 1996 | 246 |
| 40 | Rectal irrigation with short-chain fatty acids for distal ulcerative colitis | Digestive Diseases and Sciences | 1991 | 240 |
| 41 | Short chain fatty acid rectal irrigation for left-sided ulcerative colitis: a randomised, placebo controlled trial. | Gut | 1997 | 236 |
| 42 | Trends in Contralateral Prophylactic Mastectomy for Unilateral Cancer: A Report From the National Cancer Data Base, 1998–2007 | Annals of Surgical Oncology | 2010 | 224 |
| 43 | Video-Assisted Thoracoscopic Lobectomy Is Less Costly and Morbid Than Open Lobectomy: A Retrospective Multiinstitutional Database Analysis | Annals of Thoracic Surgery | 2012 | 223 |
| 44 | Effect of Spinal Cord Injury on the Respiratory System | American Journal of Physical Medicine and Rehabilitation | 2003 | 215 |
| 45 | Tumor-infiltrating lymphocytes are a marker for microsatellite instability in colorectal carcinoma | Cancer | 2001 | 207 |
| 46 | Transcatheter Interatrial Shunt Device for the Treatment of Heart Failure With Preserved Ejection Fraction (REDUCE LAP-HF I [Reduce Elevated Left Atrial Pressure in Patients With Heart Failure]) | Circulation | 2018 | 206 |
| 47 | Supratentorial Gliomas: Surgical Considerations and Immediate Postoperative Results Gross Total Resection versus Partial Resection | Neurosurgery | 1987 | 205 |
| 48 | Role of Asphyxia and Feeding in a Neonatal Rat Model of Necrotizing Enterocolitis | Pediatric Pathology | 1994 | 202 |
| 49 | Echocardiographic Guidance and Assessment of Percutaneous Repair for Mitral Regurgitation With the Evalve MitraClip: Lessons Learned From EVEREST I | Journal of the American Society of Echocardiography | 2007 | 200 |
| 50 | The predominant virus antigen burden is present in macrophages in Theiler's murine encephalomyelitis virus-induced demyelinating disease | Journal of Virology | 1995 | 193 |
