| # | Title | Journal | Year | Citations |
|---|
| 1 | Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes | New England Journal of Medicine | 2017 | 5,629 |
| 2 | SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials | BMJ, The | 2013 | 3,435 |
| 3 | The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics | Nature Reviews Drug Discovery | 2011 | 1,766 |
| 4 | Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease | New England Journal of Medicine | 2014 | 1,613 |
| 5 | Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study | Lancet Oncology, The | 2012 | 1,182 |
| 6 | Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia | JAMA - Journal of the American Medical Association | 2015 | 1,166 |
| 7 | Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study | Lancet Oncology, The | 2015 | 1,100 |
| 8 | Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma | New England Journal of Medicine | 2015 | 948 |
| 9 | Mapping genomic loci implicates genes and synaptic biology in schizophrenia | Nature | 2022 | 929 |
| 10 | The challenge of new drug discovery for tuberculosis | Nature | 2011 | 887 |
| 11 | Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects | Nature Genetics | 2017 | 838 |
| 12 | Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor | Cell | 2018 | 834 |
| 13 | Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptors | Life Sciences | 1981 | 821 |
| 14 | Adeno-Associated Virus (AAV) as a Vector for Gene Therapy | BioDrugs | 2017 | 773 |
| 15 | Daratumumab monotherapy in patients with treatment-refractory multiple myeloma (SIRIUS): an open-label, randomised, phase 2 trial | Lancet, The | 2016 | 724 |
| 16 | Ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study | Lancet, The | 2021 | 711 |
| 17 | The promise and peril of chemical probes | Nature Chemical Biology | 2015 | 698 |
| 18 | Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma | Blood | 2016 | 697 |
| 19 | Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism | New England Journal of Medicine | 2017 | 577 |
| 20 | Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease | Nature Medicine | 2017 | 571 |
| 21 | A scalable SCENIC workflow for single-cell gene regulatory network analysis | Nature Protocols | 2020 | 553 |
| 22 | PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs | Journal of Pharmaceutical Sciences | 2016 | 551 |
| 23 | The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception | Alzheimer's and Dementia | 2013 | 535 |
| 24 | Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy | Cell | 2019 | 519 |
| 25 | GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates | Nature Medicine | 2017 | 507 |
| 26 | Abiraterone acetate plus prednisone in patients with newly diagnosed high-risk metastatic castration-sensitive prostate cancer (LATITUDE): final overall survival analysis of a randomised, double-blind, phase 3 trial | Lancet Oncology, The | 2019 | 496 |
| 27 | Recommendations on health-related quality of life research to support labeling and promotional claims in the United States | Quality of Life Research | 2000 | 460 |
| 28 | Development and validation of the Patient Assessment of Constipation Quality of Life questionnaire | Scandinavian Journal of Gastroenterology | 2005 | 446 |
| 29 | Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis | Molecular Psychiatry | 2017 | 446 |
| 30 | Micronuclei as an index of cytogenetic damage: Past, present, and future | Environmental and Molecular Mutagenesis | 1991 | 444 |
| 31 | The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception | Alzheimer's and Dementia | 2012 | 432 |
| 32 | Incorporating the Patient's Perspective into Drug Development and Communication: An Ad Hoc Task Force Report of the Patient-Reported Outcomes (PRO) Harmonization Group Meeting at the Food and Drug Administration, February 16, 2001 | Value in Health | 2003 | 431 |
| 33 | Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial | Lancet, The | 2014 | 431 |
| 34 | Fundamental aspects of solid dispersion technology for poorly soluble drugs | Acta Pharmaceutica Sinica B | 2014 | 422 |
| 35 | Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1) | International Journal of Neuropsychopharmacology | 2019 | 404 |
| 36 | Long-acting intramuscular cabotegravir and rilpivirine in adults with HIV-1 infection (LATTE-2): 96-week results of a randomised, open-label, phase 2b, non-inferiority trial | Lancet, The | 2017 | 391 |
| 37 | ATP-Citrate Lyase: A Key Player in Cancer Metabolism | Cancer Research | 2012 | 389 |
| 38 | Randomized Phase III Trial of Ibrutinib and Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Non–Germinal Center B-Cell Diffuse Large B-Cell Lymphoma | Journal of Clinical Oncology | 2019 | 388 |
| 39 | Simeprevir with pegylated interferon alfa 2a or 2b plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-2): a randomised, double-blind, placebo-controlled phase 3 trial | Lancet, The | 2014 | 376 |
| 40 | Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study | Lancet Oncology, The | 2016 | 373 |
| 41 | Cyclodextrins as Functional Excipients: Methods to Enhance Complexation Efficiency | Journal of Pharmaceutical Sciences | 2012 | 364 |
| 42 | The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers | Alzheimer's and Dementia | 2011 | 354 |
| 43 | Therapeutic strategies for hepatitis B virus infection: towards a cure | Nature Reviews Drug Discovery | 2019 | 352 |
| 44 | Clinical efficacy of daratumumab monotherapy in patients with heavily pretreated relapsed or refractory multiple myeloma | Blood | 2016 | 347 |
| 45 | Efficacy and Safety of Rivaroxaban Compared With Warfarin Among Elderly Patients With Nonvalvular Atrial Fibrillation in the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) | Circulation | 2014 | 345 |
| 46 | Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease | Journal of Allergy and Clinical Immunology | 2015 | 332 |
| 47 | IL-33 is more potent than IL-25 in provoking IL-13–producing nuocytes (type 2 innate lymphoid cells) and airway contraction | Journal of Allergy and Clinical Immunology | 2013 | 331 |
| 48 | Acquired Resistance of Mycobacterium tuberculosis to Bedaquiline | PLoS ONE | 2014 | 320 |
| 49 | Evidence for a role of the N-methyl-d-aspartate (NMDA) receptor in cortical spreading depression in the rat | Brain Research | 1988 | 304 |
| 50 | Recent Advances in Enantioselective Pd-Catalyzed Allylic Substitution: From Design to Applications | Chemical Reviews | 2021 | 302 |
