| # | Title | Journal | Year | Citations |
|---|
| 1 | In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state | Nature | 2007 | 2,517 |
| 2 | Many roads to maturity: microRNA biogenesis pathways and their regulation | Nature Cell Biology | 2009 | 2,328 |
| 3 | Disease-Specific Induced Pluripotent Stem Cells | Cell | 2008 | 2,071 |
| 4 | Hematopoiesis: An Evolving Paradigm for Stem Cell Biology | Cell | 2008 | 2,061 |
| 5 | Epigenetic memory in induced pluripotent stem cells | Nature | 2010 | 2,011 |
| 6 | The bone marrow niche for haematopoietic stem cells | Nature | 2014 | 1,910 |
| 7 | In vivo reprogramming of adult pancreatic exocrine cells to β-cells | Nature | 2008 | 1,892 |
| 8 | Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons | Science | 2008 | 1,826 |
| 9 | The stem-cell niche as an entity of action | Nature | 2006 | 1,665 |
| 10 | Generation of Functional Human Pancreatic β Cells In Vitro | Cell | 2014 | 1,643 |
| 11 | Directly Reprogrammed Fibroblasts Show Global Epigenetic Remodeling and Widespread Tissue Contribution | Cell Stem Cell | 2007 | 1,596 |
| 12 | Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds | Nature Biotechnology | 2008 | 1,491 |
| 13 | Neuronal subtype specification in the cerebral cortex | Nature Reviews Neuroscience | 2007 | 1,444 |
| 14 | M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination | Nature Neuroscience | 2013 | 1,357 |
| 15 | Selective Blockade of MicroRNA Processing by Lin28 | Science | 2008 | 1,316 |
| 16 | Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak | Cancer Discovery | 2020 | 1,286 |
| 17 | Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis | American Journal of Pathology | 2010 | 1,281 |
| 18 | Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2 | Nature Biotechnology | 2008 | 1,249 |
| 19 | Bayesian approach to single-cell differential expression analysis | Nature Methods | 2014 | 1,186 |
| 20 | Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2 | Nature | 2010 | 1,160 |
| 21 | Somatic coding mutations in human induced pluripotent stem cells | Nature | 2011 | 1,147 |
| 22 | Neuronal Subtype-Specific Genes that Control Corticospinal Motor Neuron Development In Vivo | Neuron | 2005 | 1,046 |
| 23 | Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis | Nature | 2007 | 1,037 |
| 24 | A protein interaction network for pluripotency of embryonic stem cells | Nature | 2006 | 1,003 |
| 25 | A three-dimensional human neural cell culture model of Alzheimer’s disease | Nature | 2014 | 950 |
| 26 | Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment | Nature | 2009 | 938 |
| 27 | Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart | Nature | 2008 | 905 |
| 28 | A paracrine requirement for hedgehog signalling in cancer | Nature | 2008 | 904 |
| 29 | In vivo gene editing in dystrophic mouse muscle and muscle stem cells | Science | 2016 | 889 |
| 30 | A revised airway epithelial hierarchy includes CFTR-expressing ionocytes | Nature | 2018 | 878 |
| 31 | Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor | Cancer Cell | 2011 | 842 |
| 32 | Nuclear Reprogramming of Somatic Cells After Fusion with Human Embryonic Stem Cells | Science | 2005 | 836 |
| 33 | In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment | Nature | 2005 | 820 |
| 34 | Stems Cells and the Pathways to Aging and Cancer | Cell | 2008 | 806 |
| 35 | Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche | Nature | 2009 | 800 |
| 36 | Immortalization eliminates a roadblock during cellular reprogramming into iPS cells | Nature | 2009 | 794 |
| 37 | Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy | Cell | 2013 | 791 |
| 38 | Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans | Cell | 2008 | 787 |
| 39 | Marked differences in differentiation propensity among human embryonic stem cell lines | Nature Biotechnology | 2008 | 764 |
| 40 | Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A | Science | 2008 | 759 |
| 41 | Intrinsic Epithelial Cells Repair the Kidney after Injury | Cell Stem Cell | 2008 | 752 |
| 42 | A Tissue-Mapped Axolotl De Novo Transcriptome Enables Identification of Limb Regeneration Factors | Cell Reports | 2017 | 752 |
| 43 | Lin28 promotes transformation and is associated with advanced human malignancies | Nature Genetics | 2009 | 742 |
| 44 | A Small-Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog | Cell Stem Cell | 2009 | 741 |
| 45 | Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells | Nature | 2011 | 738 |
| 46 | Non–cell autonomous effect of glia on motor neurons in an embryonic stem cell–based ALS model | Nature Neuroscience | 2007 | 727 |
| 47 | Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells | Nature | 2010 | 727 |
| 48 | BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis | Nature | 2015 | 726 |
| 49 | Targeting the Hedgehog pathway in cancer | Nature Reviews Drug Discovery | 2006 | 724 |
| 50 | Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle | Science | 2014 | 706 |
