| # | Title | Journal | Year | Citations |
|---|
| 1 | Improving the quality of reporting of randomized controlled trials. The CONSORT statement | JAMA - Journal of the American Medical Association | 1996 | 2,883 |
| 2 | Assessing the quality of randomized controlled trials: An annotated bibliography of scales and checklists | Contemporary Clinical Trials | 1995 | 1,089 |
| 3 | Accuracy of clinical assessment of deep-vein thrombosis | Lancet, The | 1995 | 705 |
| 4 | A study to develop clinical decision rules for the use of radiography in acute ankle injuries | Annals of Emergency Medicine | 1992 | 567 |
| 5 | CpG DNA Is a Potent Enhancer of Specific Immunity in Mice Immunized with Recombinant Hepatitis B Surface Antigen | Journal of Immunology | 1998 | 554 |
| 6 | A Clinical Grading Scale to Predict Malignant Hyperthermia Susceptibility | Anesthesiology | 1994 | 520 |
| 7 | CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen | Journal of Immunology | 1998 | 490 |
| 8 | Statistical Power, Sample Size, and Their Reporting in Randomized Controlled Trials | JAMA - Journal of the American Medical Association | 1994 | 418 |
| 9 | Propofol vs Midazolam for ICU Sedation | Chest | 2001 | 402 |
| 10 | Asymptomatic Cardiac Ischemia Pilot (ACIP) Study Two-Year Follow-up | Circulation | 1997 | 378 |
| 11 | A microsatellite genetic linkage map for zebrafish (Danio rerio) | Nature Genetics | 1998 | 333 |
| 12 | Can disturbed brain microcirculation cause Alzheimer’s disease? | Neurological Research | 1993 | 329 |
| 13 | Neurophysiology and neuropharmacology of hypothalamic magnocellular neurons secreting vasopressin and oxytocin | Progress in Neurobiology | 1991 | 325 |
| 14 | Pituitary Apoplexy: A Review | Neurosurgery | 1984 | 318 |
| 15 | Effect of dose and modification of viscous properties of oat gum on plasma glucose and insulin following an oral glucose load | British Journal of Nutrition | 1994 | 317 |
| 16 | Pleomorphic xanthoastrocytoma | Cancer | 1999 | 312 |
| 17 | Accuracy of Ultrasound for the Diagnosis of Deep Venous Thrombosis in Asymptomatic Patients after Orthopedic Surgery | Annals of Internal Medicine | 1995 | 296 |
| 18 | Awareness, Treatment, and Control of Hypertension in Canada | American Journal of Hypertension | 1997 | 294 |
| 19 | Differential induction of four msx homeobox genes during fin development and regeneration in zebrafish | Development (Cambridge) | 1995 | 289 |
| 20 | Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats | Neuroscience Letters | 1991 | 251 |
| 21 | Pituitary Apoplexy: A Review | Neurosurgery | 1984 | 242 |
| 22 | Low-dose cyclosporin versus placebo in patients with rheumatoid arthritis | Lancet, The | 1990 | 236 |
| 23 | DNA vaccine for hepatitis B: evidence for immunogenicity in chimpanzees and comparison with other vaccines. | Proceedings of the National Academy of Sciences of the United States of America | 1996 | 228 |
| 24 | Living with a person who has parkinson's disease: The Spouse's perspective by stage of disease | Movement Disorders | 1998 | 222 |
| 25 | Mechanosensitive ion channels in nonspecialized cells | Movement Disorders | 1998 | 222 |
| 26 | Oat beta-glucan reduces blood cholesterol concentration in hypercholesterolemic subjects | European Journal of Clinical Nutrition | 1994 | 219 |
| 27 | Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease | Acta Neuropathologica | 1992 | 214 |
| 28 | Sedation for intractable distress in the dying–a survey of experts | Palliative Medicine | 1998 | 214 |
| 29 | Nuclear localization signals overlap DNA- or RNA-binding domains in nucleic acid-binding proteins | Nucleic Acids Research | 1995 | 211 |
| 30 | Sequence-specific DNA binding by Ku autoantigen and its effects on transcription | Nature | 1996 | 210 |
| 31 | The lines of Blaschko: a review and reconsideration | British Journal of Dermatology | 1976 | 204 |
| 32 | Preeclampsia in diabetic pregnancies | American Journal of Obstetrics and Gynecology | 1990 | 199 |
| 33 | Proprotein Convertases in Tumor Progression and Malignancy | American Journal of Pathology | 2002 | 196 |
| 34 | Body image and steroid use in male bodybuilders | International Journal of Eating Disorders | 1995 | 192 |
| 35 | Does Acute Normovolemic Hemodilution Reduce Perioperative Allogeneic Transfusion? A Meta-Analysis | Anesthesia and Analgesia | 1998 | 190 |
| 36 | The Contribution of Basal Forebrain to Limbic — Motor Integration and the Mediation of Motivation to Action | Advances in Experimental Medicine and Biology | 1991 | 188 |
| 37 | Immediate Postoperative Enteral Feeding Results in Impaired Respiratory Mechanics and Decreased Mobility | Annals of Surgery | 1997 | 187 |
| 38 | Computerized administration of the diagnostic interview schedule | Psychiatry Research | 1988 | 184 |
| 39 | Distribution of blood pressure and hypertension in Canada and the United States | American Journal of Hypertension | 2001 | 182 |
| 40 | Immediate or delayed mild hypothermia prevents focal cerebral infarction | Brain Research | 1992 | 177 |
| 41 | Canadian stroke best practice recommendations: Secondary prevention of stroke, sixth edition practice guidelines, update 2017 | International Journal of Stroke | 2018 | 175 |
| 42 | A multicenter double-blind placebo-controlled trial of pergolide as an adjunct to sinemet® in Parkinson's disease | Movement Disorders | 1994 | 174 |
| 43 | Clinical and Environmental Aspects of Arsenic Toxicity | CRC Critical Reviews in Clinical Laboratory Sciences | 1986 | 171 |
| 44 | Delayed Treatment with AMPA, but Not NMDA, Antagonists Reduces Neocortical Infarction | Journal of Cerebral Blood Flow and Metabolism | 1994 | 166 |
| 45 | Spinal subdural hematoma a review | World Neurosurgery | 1983 | 165 |
| 46 | Aortic aneurysm in patients with functionally normal or minimally stenotic bicuspid aortic valve | American Journal of Cardiology | 1991 | 165 |
| 47 | Involvement of the Sonic Hedgehog, patched 1 and bmp2 genes in patterning of the zebrafish dermal fin rays | Development (Cambridge) | 1998 | 164 |
| 48 | Postarthroscopy Analgesia with Intraarticular Bupivacaine/Morphine | Anesthesiology | 1993 | 161 |
| 49 | Interaction of Intrathecal Morphine with Bupivacaine and Lidocaine in the Rat | Anesthesiology | 1992 | 159 |
| 50 | DNA-mediated immunization to hepatitis B surface antigen: longevity of primary response and effect of boost | Vaccine | 1996 | 159 |
