| # | Title | Journal | Year | Citations |
|---|
| 1 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial | Lancet Oncology, The | 2009 | 5,104 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Frequent pathway mutations of splicing machinery in myelodysplasia | Nature | 2011 | 1,764 |
| 4 | Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet, The | 2017 | 1,749 |
| 5 | A marker for Stevens–Johnson syndrome | Nature | 2004 | 1,578 |
| 6 | MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 1,557 |
| 7 | Hepatitis B virus infection | Lancet, The | 2009 | 1,106 |
| 8 | Have We Found an Ideal Soft-Tissue Flap? An Experience with 672 Anterolateral Thigh Flaps | Plastic and Reconstructive Surgery | 2002 | 1,095 |
| 9 | Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma | Hepatology International | 2010 | 944 |
| 10 | Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update | Hepatology International | 2012 | 874 |
| 11 | Reconstruction of Damaged Corneas by Transplantation of Autologous Limbal Epithelial Cells | New England Journal of Medicine | 2000 | 866 |
| 12 | Global epidemiology of gout: prevalence, incidence and risk factors | Nature Reviews Rheumatology | 2015 | 854 |
| 13 | Adjuvant capecitabine plus oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): 5-year follow-up of an open-label, randomised phase 3 trial | Lancet Oncology, The | 2014 | 849 |
| 14 | Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B | Hepatology | 2010 | 840 |
| 15 | Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics | Clinica Chimica Acta | 2004 | 824 |
| 16 | Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib | JAMA Oncology | 2020 | 746 |
| 17 | Draft Genome Sequence of the Sexually Transmitted Pathogen Trichomonas vaginalis | Science | 2007 | 731 |
| 18 | Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholecystitis (with videos) | Journal of Hepato-Biliary-Pancreatic Sciences | 2018 | 723 |
| 19 | Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA) | Annals of the Rheumatic Diseases | 2014 | 659 |
| 20 | Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis | Nature Medicine | 2008 | 653 |
| 21 | Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma | Cancer Discovery | 2017 | 637 |
| 22 | Carbamazepine-Induced Toxic Effects and HLA-B*1502 Screening in Taiwan | New England Journal of Medicine | 2011 | 631 |
| 23 | Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B | Hepatology | 2002 | 600 |
| 24 | Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma ≤4 cm | Gastroenterology | 2004 | 600 |
| 25 | Psychological impact of severe acute respiratory syndrome on health workers in a tertiary hospital | British Journal of Psychiatry | 2004 | 569 |
| 26 | The development of cirrhosis in patients with chronic type B hepatitis: A prospective study | Hepatology | 1988 | 568 |
| 27 | Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: Results after 3 years of therapy | Hepatology | 2001 | 565 |
| 28 | The genetics of asthma and allergic disease: a 21st century perspective | Immunological Reviews | 2011 | 537 |
| 29 | Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy | Hepatology | 1999 | 535 |
| 30 | 2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B | Gastroenterology | 2009 | 527 |
| 31 | Randomised controlled trial comparing percutaneous radiofrequency thermal ablation, percutaneous ethanol injection, and percutaneous acetic acid injection to treat hepatocellular carcinoma of 3 cm or less | Gut | 2005 | 526 |
| 32 | Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis | Gut | 2019 | 524 |
| 33 | A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4 | Nature Genetics | 2010 | 518 |
| 34 | The Novel Coronavirus 2019 epidemic and kidneys | Kidney International | 2020 | 502 |
| 35 | Shedding the cobra effect: problematising thematic emergence, triangulation, saturation and member checking | Medical Education | 2017 | 487 |
| 36 | The after-effect of human theta burst stimulation is NMDA receptor dependent | Clinical Neurophysiology | 2007 | 486 |
| 37 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update | Hepatology International | 2019 | 483 |
| 38 | Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study | Annals of the Rheumatic Diseases | 2015 | 472 |
| 39 | Tokyo Guidelines 2018: flowchart for the management of acute cholecystitis | Journal of Hepato-Biliary-Pancreatic Sciences | 2018 | 470 |
| 40 | Are children less susceptible to COVID-19? | Journal of Microbiology, Immunology and Infection | 2020 | 469 |
| 41 | Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease | JAMA Neurology | 2017 | 454 |
| 42 | Cancer-Associated Mutations in Endometriosis without Cancer | New England Journal of Medicine | 2017 | 451 |
| 43 | A Meta-Analytic Review of Polyunsaturated Fatty Acid Compositions in Patients with Depression | Biological Psychiatry | 2010 | 439 |
| 44 | Standardization of terminology of pelvic floor muscle function and dysfunction: Report from the pelvic floor clinical assessment group of the International Continence Society | Neurourology and Urodynamics | 2005 | 433 |
| 45 | A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells | Blood | 2008 | 431 |
| 46 | Epidemiological characteristics and risk factors of hepatocellular carcinoma | Journal of Gastroenterology and Hepatology (Australia) | 1997 | 425 |
| 47 | Diagnostic accuracy of the Berlin questionnaire, STOP-BANG, STOP, and Epworth sleepiness scale in detecting obstructive sleep apnea: A bivariate meta-analysis | Sleep Medicine Reviews | 2017 | 418 |
| 48 | A Comprehensive Review on Current Advances in Peptide Drug Development and Design | International Journal of Molecular Sciences | 2019 | 413 |
| 49 | Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 405 |
| 50 | The impact of delirium on the survival of mechanically ventilated patients* | Critical Care Medicine | 2004 | 405 |
