| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Hypoxia — a key regulatory factor in tumour growth | Nature Reviews Cancer | 2002 | 4,590 |
| 3 | Genome sequence of the human malaria parasite Plasmodium falciparum | Nature | 2002 | 3,881 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 5 | Nomenclature for factors of the HLA system, 2010 | Tissue Antigens | 2010 | 3,121 |
| 6 | Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors | Nature | 2015 | 1,724 |
| 7 | Immunopathology of multiple sclerosis | Nature Reviews Immunology | 2015 | 1,642 |
| 8 | The mystery of membrane organization: composition, regulation and roles of lipid rafts | Nature Reviews Molecular Cell Biology | 2017 | 1,471 |
| 9 | Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins | Nature Immunology | 2004 | 1,208 |
| 10 | Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia | Blood | 2017 | 1,173 |
| 11 | A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1 | Science | 2007 | 1,136 |
| 12 | Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions | Cell | 2010 | 1,069 |
| 13 | Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis | American Journal of Pathology | 2008 | 1,018 |
| 14 | NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation | Nature Medicine | 2010 | 926 |
| 15 | Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma | Molecular and Cellular Biology | 2005 | 847 |
| 16 | Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer | Nature Reviews Cancer | 2015 | 839 |
| 17 | Forcing cells to change lineages | Nature | 2009 | 817 |
| 18 | Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria | Nature Genetics | 2001 | 803 |
| 19 | SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses | Cell | 2022 | 788 |
| 20 | Sickle cell disease | Nature Reviews Disease Primers | 2018 | 764 |
| 21 | The ABC of APC | Human Molecular Genetics | 2001 | 759 |
| 22 | Genetic variegation of clonal architecture and propagating cells in leukaemia | Nature | 2011 | 734 |
| 23 | Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever | Nature Medicine | 2003 | 707 |
| 24 | The immune response during acute HIV-1 infection: clues for vaccine development | Nature Reviews Immunology | 2010 | 707 |
| 25 | The inherited diseases of hemoglobin are an emerging global health burden | Blood | 2010 | 659 |
| 26 | Combinatorial Transcriptional Control In Blood Stem/Progenitor Cells: Genome-wide Analysis of Ten Major Transcriptional Regulators | Cell Stem Cell | 2010 | 623 |
| 27 | Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8α+ dendritic cells | Journal of Experimental Medicine | 2010 | 613 |
| 28 | Advances in Hypoxia-Inducible Factor Biology | Cell Metabolism | 2018 | 571 |
| 29 | The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection | Journal of Experimental Medicine | 2009 | 562 |
| 30 | Up-Regulation of the Lymphatic Marker Podoplanin, a Mucin-Type Transmembrane Glycoprotein, in Human Squamous Cell Carcinomas and Germ Cell Tumors | American Journal of Pathology | 2005 | 552 |
| 31 | Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis | Brain | 2012 | 549 |
| 32 | The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance | Journal of Experimental Medicine | 2011 | 539 |
| 33 | Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis | Nature Reviews Neurology | 2014 | 507 |
| 34 | Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease | Nature Genetics | 2003 | 505 |
| 35 | Bifurcation dynamics in lineage-commitment in bipotent progenitor cells | Developmental Biology | 2007 | 494 |
| 36 | Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy | Nature | 2013 | 493 |
| 37 | PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis | Cancer Cell | 2004 | 480 |
| 38 | Ironing out Ferroportin | Cell Metabolism | 2015 | 474 |
| 39 | The kinetic-segregation model: TCR triggering and beyond | Nature Immunology | 2006 | 470 |
| 40 | Regulation of tumor pH and the role of carbonic anhydrase 9 | Cancer and Metastasis Reviews | 2007 | 470 |
| 41 | Surfactant proteins SP-A and SP-D: Structure, function and receptors | Molecular Immunology | 2006 | 468 |
| 42 | Multilocus Sequence Typing and Evolutionary Relationships among the Causative Agents of Melioidosis and Glanders, Burkholderia pseudomallei and Burkholderia mallei | Journal of Clinical Microbiology | 2003 | 459 |
| 43 | HIF activation identifies early lesions in VHL kidneys | Cancer Cell | 2002 | 456 |
| 44 | Exported Proteins Required for Virulence and Rigidity of Plasmodium falciparum-Infected Human Erythrocytes | Cell | 2008 | 450 |
| 45 | T Cell Responses to Whole SARS Coronavirus in Humans | Journal of Immunology | 2008 | 449 |
| 46 | Second international consensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours | European Journal of Cancer | 2002 | 442 |
| 47 | IgG1 antibodies to acetylcholine receptors in ‘seronegative’ myasthenia gravis† | Brain | 2008 | 438 |
| 48 | Sialic acid utilization by bacterial pathogens | Microbiology (United Kingdom) | 2007 | 436 |
| 49 | Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 | Nature Structural and Molecular Biology | 2020 | 434 |
| 50 | Consensus guidelines for the use and interpretation of angiogenesis assays | Angiogenesis | 2018 | 429 |
