| # | Title | Journal | Year | Citations |
|---|
| 1 | Antithrombotic Therapy for VTE Disease | Chest | 2016 | 4,060 |
| 2 | Evolution of Mortality over Time in Patients Receiving Mechanical Ventilation | American Journal of Respiratory and Critical Care Medicine | 2013 | 999 |
| 3 | The gut-liver axis in liver disease: Pathophysiological basis for therapy | Journal of Hepatology | 2020 | 935 |
| 4 | New insights into the genetic etiology of Alzheimer’s disease and related dementias | Nature Genetics | 2022 | 700 |
| 5 | Defining and combating antibiotic resistance from One Health and Global Health perspectives | Nature Microbiology | 2019 | 614 |
| 6 | COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study | Lancet Oncology, The | 2020 | 503 |
| 7 | Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-on-chronic liver failure: The RELIEF trial | Hepatology | 2013 | 452 |
| 8 | The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria: report from the EUCAST Subcommittee | Clinical Microbiology and Infection | 2017 | 428 |
| 9 | Frontal fibrosing alopecia: A multicenter review of 355 patients | Journal of the American Academy of Dermatology | 2014 | 362 |
| 10 | Advances and challenges for fluorescence nanothermometry | Nature Methods | 2020 | 333 |
| 11 | Amivantamab in EGFR Exon 20 Insertion–Mutated Non–Small-Cell Lung Cancer Progressing on Platinum Chemotherapy: Initial Results From the CHRYSALIS Phase I Study | Journal of Clinical Oncology | 2021 | 320 |
| 12 | The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology | Journal of Hepatology | 2020 | 282 |
| 13 | Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma | Cancer Cell | 2016 | 281 |
| 14 | Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer | JAMA Oncology | 2017 | 260 |
| 15 | Impact of Thrombolytic Therapy on the Long-Term Outcome of Intermediate-Risk Pulmonary Embolism | Journal of the American College of Cardiology | 2017 | 258 |
| 16 | Emergence and spread of antibiotic resistance following exposure to antibiotics | FEMS Microbiology Reviews | 2011 | 256 |
| 17 | Risk Factors and Outcomes for Late Presentation for HIV-Positive Persons in Europe: Results from the Collaboration of Observational HIV Epidemiological Research Europe Study (COHERE) | PLoS Medicine | 2013 | 256 |
| 18 | Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF | Journal of Hepatology | 2020 | 223 |
| 19 | Parkinson's disease severity levels and MDS-Unified Parkinson's Disease Rating Scale | Parkinsonism and Related Disorders | 2015 | 216 |
| 20 | MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels | Nature Medicine | 2015 | 203 |
| 21 | Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib/IIa clinical trial | Annals of the Rheumatic Diseases | 2017 | 194 |
| 22 | Beyond horizontal gene transfer: the role of plasmids in bacterial evolution | Nature Reviews Microbiology | 2021 | 194 |
| 23 | Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 Drug Resistance: An Individual-Patient- and Sequence-Level Meta-Analysis | PLoS Medicine | 2015 | 188 |
| 24 | Identification of intermediate-risk patients with acute symptomatic pulmonary embolism | European Respiratory Journal | 2014 | 186 |
| 25 | Increased Risk of Serious Non-AIDS-Related Events in HIV-Infected Subjects on Antiretroviral Therapy Associated with a Low CD4/CD8 Ratio | PLoS ONE | 2014 | 175 |
| 26 | Expanded and independent validation of the Movement Disorder Society–Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) | Journal of Neurology | 2013 | 169 |
| 27 | Derivation and Validation of Multimarker Prognostication for Normotensive Patients with Acute Symptomatic Pulmonary Embolism | American Journal of Respiratory and Critical Care Medicine | 2014 | 164 |
| 28 | Co-resistance: an opportunity for the bacteria and resistance genes | Current Opinion in Pharmacology | 2011 | 162 |
| 29 | Association Between Portosystemic Shunts and Increased Complications and Mortality in Patients With Cirrhosis | Gastroenterology | 2018 | 162 |
| 30 | L-DOPA Treatment Selectively Restores Spine Density in Dopamine Receptor D2–Expressing Projection Neurons in Dyskinetic Mice | Biological Psychiatry | 2014 | 155 |
| 31 | FXR modulates the gut-vascular barrier by regulating the entry sites for bacterial translocation in experimental cirrhosis | Journal of Hepatology | 2019 | 153 |
| 32 | Mir-33 regulates cell proliferation and cell cycle progression | Cell Cycle | 2012 | 150 |
| 33 | A preliminary observation: Male pattern hair loss among hospitalized COVID‐19 patients in Spain – A potential clue to the role of androgens in COVID‐19 severity | Journal of Cosmetic Dermatology | 2020 | 149 |
| 34 | PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis | Journal of Hepatology | 2021 | 149 |
| 35 | Chitinase 3-like 1: prognostic biomarker in clinically isolated syndromes | Brain | 2015 | 147 |
| 36 | Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis | Journal of Clinical Investigation | 2021 | 147 |
| 37 | The high‐osmolarity glycerol (HOG) and cell wall integrity (CWI) signalling pathways interplay: a yeast dialogue between MAPK routes | Yeast | 2010 | 145 |
| 38 | CB2 Cannabinoid Receptors Promote Neural Progenitor Cell Proliferation via mTORC1 Signaling | Journal of Biological Chemistry | 2012 | 145 |
| 39 | Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores | Nature Communications | 2021 | 140 |
| 40 | Obeticholic acid reduces bacterial translocation and inhibits intestinal inflammation in cirrhotic rats | Journal of Hepatology | 2016 | 139 |
| 41 | Early prosthetic joint infection: outcomes with debridement and implant retention followed by antibiotic therapy | Clinical Microbiology and Infection | 2011 | 136 |
| 42 | Evaluation of Epidemiological Cut-Off Values Indicates that Biocide Resistant Subpopulations Are Uncommon in Natural Isolates of Clinically-Relevant Microorganisms | PLoS ONE | 2014 | 135 |
| 43 | Durable treatment-free remission in patients with chronic myeloid leukemia in chronic phase following frontline nilotinib: 96-week update of the ENESTfreedom study | Journal of Cancer Research and Clinical Oncology | 2018 | 124 |
| 44 | Variations in the Occurrence of Resistance Phenotypes and Carbapenemase Genes Among Enterobacteriaceae Isolates in 20 Years of the SENTRY Antimicrobial Surveillance Program | Open Forum Infectious Diseases | 2019 | 124 |
| 45 | Dual treatment with atazanavir–ritonavir plus lamivudine versus triple treatment with atazanavir–ritonavir plus two nucleos(t)ides in virologically stable patients with HIV-1 (SALT): 48 week results from a randomised, open-label, non-inferiority trial | Lancet Infectious Diseases, The | 2015 | 122 |
| 46 | Infrared‐Emitting QDs for Thermal Therapy with Real‐Time Subcutaneous Temperature Feedback | Advanced Functional Materials | 2016 | 117 |
| 47 | Combinations of prognostic tools for identification of high-risk normotensive patients with acute symptomatic pulmonary embolism | Thorax | 2011 | 115 |
| 48 | Neurofilament light chain and oligoclonal bands are prognostic biomarkers in radiologically isolated syndrome | Brain | 2018 | 115 |
| 49 | Randomized placebo-controlled trial of emricasan for non-alcoholic steatohepatitis-related cirrhosis with severe portal hypertension | Journal of Hepatology | 2020 | 107 |
| 50 | Early discharge and home treatment of patients with low-risk pulmonary embolism with the oral factor Xa inhibitor rivaroxaban: an international multicentre single-arm clinical trial | European Heart Journal | 2020 | 106 |
